公开(公告)号：JPH04321629A

公开(公告)日：1992-11-11

申请号：JP1683391

申请日：1991-01-18

Applicant: SCLAVO SPA

Inventor： RUKA PARENTE ,  KENISU MAGURITSUJI ,  JIYON WARESU ,  KIYASARIN KIINAN

IPC: A61K38/00 ,  A61K31/60 ,  A61K38/20 ,  A61P1/04

Abstract: PURPOSE: To prepare a gastroduodenal protector for treating benign relapsing and postoperative ulcers comprising a human interleukin-1β (IL-1β) as an active ingredient. CONSTITUTION: This pharmaceutical composition comprises a compound having an amino acid sequence corresponding to an amino acid sequence of a human IL-1β, e.g. a recombinant human IL-1β or a human IL-1β isolated from a human leukocyte as an active ingredient. The human IL-1β is prepared as a dosage form suitable for oral, intravenous or parenteral administration and the daily dose of the compound contained in the pharmaceutical preparation is usually 0.1-10μg based on 1kg body weight. In the case of the oral administration, the compound is formulated in combination with a nonsteroidal antiinflammatory agent selected from salicylic acid, indomethacin, ibuprofen and piroxicam in a therapeutically effective amount in order to antagonize the gastrolesive effects of the human IL-1β.