公开(公告)号：JPH0698798A

公开(公告)日：1994-04-12

申请号：JP5807693

申请日：1993-02-24

Applicant: SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST

IPC: C12N15/09 ,  C12Q1/68 ,  C12N15/10 ,  C12N15/36 ,  C12N15/62

公开(公告)号：WO03031929A3

公开(公告)日：2003-08-14

申请号：PCT/US0229845

申请日：2002-10-09

Applicant: XEROX CORP ,  SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST ,  BRUCE RICHARD ,  ELROD SCOTT A ,  FITCH JOHN STUART ,  HSIEH HUANGPIN BEN ,  PEETERS ERIC ,  LERNER RICHARD A

IPC: C12N15/09 ,  B01L3/00 ,  C12M1/00 ,  G01N35/10 ,  C12Q1/68 ,  C07H21/04 ,  C12M1/36 ,  C12N11/16 ,  C12P21/06

CPC classification number: B01L3/50853 ,  B01L2300/047 ,  B01L2300/0829 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N35/1074 ,  G01N2035/1037

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.

Abstract translation: 本发明提供用于分析遗传物质的装置，其包括基底和第一遗传物质位置以及在基底上的第二遗传物质位置，每个遗传物质包含附着于该基质的遗传物质。 本发明还提供了分发遗传物质的方法，包括分配至少一种装置。

公开(公告)号：WO2004037373A3

公开(公告)日：2004-07-15

申请号：PCT/US0333670

申请日：2003-10-21

Applicant: SCRIPPS RESEARCH INST ,  KELLY JEFFREY W ,  SAWKAR ANU R ,  BEUTLER ERNEST ,  WONG CHI-HEUY ,  BALCH WILLIAM E

Inventor： KELLY JEFFREY W ,  SAWKAR ANU R ,  BEUTLER ERNEST ,  WONG CHI-HEUY ,  BALCH WILLIAM E

IPC: A61K31/40 ,  A61K31/445 ,  C07D207/16 ,  C07D295/02 ,  C07D295/03 ,  C07D295/088 ,  C07D491/04 ,  C07D211/06 ,  C07D207/04

CPC classification number: C07D295/03 ,  A61K31/40 ,  A61K31/445 ,  C07D207/16 ,  C07D295/088 ,  C07D491/04

Abstract: A process of increasing the beta-glucosidase activity associated with Gaucher disease is provided. The process includes exposing the glucosidase to a chemical chaperone that has a high ratio of chaperone activity to inhibitor activity against glucosidase. Exemplary and preferred chaperones are a sterically bulky deoxynojirimycin compound and a sterically bulky 2,5-dideoxy-2,5-imino-D-mannitol compound. A process of stabilizing beta-glucosidase is also provided.

Abstract translation: 提供了增加与戈谢病相关的β-葡糖苷酶活性的方法。 该方法包括将葡糖苷酶暴露于化学伴侣，其具有高比值的伴侣活性与对葡糖苷酶的抑制剂活性。 示例性和优选的分子伴侣是空间体积大的脱氧野尻霉素化合物和空间庞大的2,5-二脱氧-2,5-亚氨基-D-甘露糖醇化合物。 还提供了稳定β-葡糖苷酶的方法。

公开(公告)号：WO0181370A2

公开(公告)日：2001-11-01

申请号：PCT/EP0104621

申请日：2001-04-24

Applicant: NOVARTIS AG ,  NOVARTIS ERFIND VERWALT GMBH ,  SCRIPPS RESEARCH INST ,  BALICKI DANUTA ,  BEUTLER ERNEST

Inventor： BALICKI DANUTA ,  BEUTLER ERNEST

IPC: C07K14/47 ,  C07K7/00

CPC classification number: C07K14/4702

Abstract: The present invention provides a novel gene delivery system in which a gene delivery facilitating peptide, generally derived from Histone H2A, is complexed with a nucleic acid for efficient and stable delivery of the nucleic acid into a cell, ultimately to the nucleus. Such peptide-mediated gene delivery is based on the principal that unneutralized positive charges on the histone are bound electrostatically both by the negatively charged phosphate backbone of DNA and that nuclear targeting signals in histones improve trafficking of the DNA to the nucleus for transcription.

Abstract translation: 本发明提供了一种新的基因递送系统，其中通常衍生自组蛋白H2A的基因递送促进肽与核酸复合，用于将核酸有效和稳定地递送到细胞中，最终到达细胞核。 这种肽介导的基因递送是基于组蛋白上的未中和正电荷被DNA的带负电的磷酸骨架静电结合的原理，并且组蛋白中的核靶向信号改善了将DNA转运到细胞核进行转录。

公开(公告)号：EP0642347A4

公开(公告)日：1997-06-18

申请号：EP93913913

申请日：1993-05-14

Applicant: SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST

IPC: C07H19/173 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P35/02

CPC classification number: A61K31/70

公开(公告)号：EP1442135A4

公开(公告)日：2006-09-13

申请号：EP02778288

申请日：2002-10-09

Applicant: XEROX CORP ,  SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST ,  BRUCE RICHARD ,  ELROD SCOTT A ,  FITCH JOHN STUART ,  HSIEH HUANGPIN BEN ,  PEETERS ERIC ,  LERNER RICHARD A

IPC: C12N15/09 ,  B01L3/00 ,  C12M1/00 ,  G01N35/10 ,  C12Q1/68 ,  C07H21/04 ,  C12M1/36 ,  C12N11/16 ,  C12P21/06

CPC classification number: B01L3/50853 ,  B01L2300/047 ,  B01L2300/0829 ,  B01L2400/0406 ,  B01L2400/0683 ,  G01N35/1074 ,  G01N2035/1037

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.

公开(公告)号：CH684310A5

公开(公告)日：1994-08-31

申请号：CH314393

申请日：1993-02-18

Applicant: SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST

IPC: C07H19/173 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P25/00 ,  A61P25/28 ,  A61P37/00 ,  C07H19/16

公开(公告)号：AU2003284886A1

公开(公告)日：2004-05-13

申请号：AU2003284886

申请日：2003-10-21

Applicant: SAWKAR ANU R ,  BEUTLER ERNEST ,  WONG CHI HEUY ,  BALCH WILLIAM E ,  SCRIPPS RESEARCH INST ,  KELLY JEFFREY W

Inventor： BEUTLER ERNEST ,  WONG CHI-HEUY ,  BALCH WILLIAM E ,  KELLY JEFFREY W ,  SAWKAR ANU R

IPC: A61K31/40 ,  A61K31/445 ,  C07D207/16 ,  C07D295/02 ,  C07D295/03 ,  C07D295/088 ,  C07D491/04

公开(公告)号：NO20000762D0

公开(公告)日：2000-02-16

申请号：NO20000762

申请日：2000-02-16

Applicant: SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST

IPC: C07H19/173 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P25/00 ,  A61P25/28 ,  A61P37/00 ,  C07H19/16 ,  A61K

Abstract: Novel adenine derivatives whose structures are represented by Formula I, are disclosed, as are methods of using those compounds and others of Formula II to treat monocyte-mediated disorders such as rheumatoid arthritis and multiple sclerosis.

公开(公告)号：FI943805A

公开(公告)日：1994-10-19

申请号：FI943805

申请日：1994-08-18

Applicant: SCRIPPS RESEARCH INST

Inventor： BEUTLER ERNEST

IPC: C07H19/173 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61P25/00 ,  A61P25/28 ,  A61P37/00 ,  C07H19/16 ,  A61K

Abstract: Novel adenine derivatives whose structures are represented by Formula I, are disclosed, as are methods of using those compounds and others of Formula II to treat monocyte-mediated disorders such as rheumatoid arthritis and multiple sclerosis.