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公开(公告)号:JP2002275196A
公开(公告)日:2002-09-25
申请号:JP2002052356
申请日:2002-01-09
Applicant: SCRIPPS RESEARCH INST
Inventor: ZAMARRON CONCEPCION , PLOW EDWARD F , GINSBERG MARK H
IPC: A61K38/00 , A61K31/00 , A61K39/395 , A61K51/00 , A61P7/00 , A61P7/02 , A61P37/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/75 , C07K16/00 , C07K16/18 , C07K16/36 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/564 , G01N33/566 , G01N33/567 , G01N33/569 , G01N33/577
Abstract: PROBLEM TO BE SOLVED: To provide a receptor-induced binding site and an antibody thereto. SOLUTION: This receptor-induced binding site comprises a polypeptide composed of up to 40 amino acid residues including an amino acid residue sequence having the formula: Ly-Thr-Arg-Trp-Tyr-Ser-Met-Lys-Lys-Thr-Thr-Met- Lys or a polyupeptide composed of up to 20 amino acid residues corresponding to the formula: Asn-Gly-Ile-Ile-Trp-Ala-Thr-Trp-Lys-Thr-Arg-Trp-Tyr-Ser-Met- Lys-Lys-Lys-Thr-Thr. The antibody recognizing the receptor-induced binding site as an epitope is formed. Furthermore, the receptor-induced binding site is used to detect the antibody.
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公开(公告)号:EP0573545A4
公开(公告)日:1995-04-12
申请号:EP92906797
申请日:1992-02-12
Applicant: SCRIPPS RESEARCH INST
Inventor: ZAMARRON CONCEPCION , PLOW EDWARD F , GINSBERG MARK H
IPC: A61K38/00 , A61K31/00 , A61K39/395 , A61K51/00 , A61P7/00 , A61P7/02 , A61P37/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K14/75 , C07K16/00 , C07K16/18 , C07K16/36 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/564 , G01N33/566 , G01N33/567 , G01N33/569 , G01N33/577 , A61K39/00 , C07K15/14 , C12N5/12
CPC classification number: C07K14/75 , A61K38/00 , C07K16/36 , G01N33/567 , G01N33/56972
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公开(公告)号:EP0619839A4
公开(公告)日:1995-09-20
申请号:EP93900897
申请日:1992-12-04
Applicant: SCRIPPS RESEARCH INST
Inventor: GINSBERG MARK H , PLOW EDWARD F , BOWDITCH RONALD
IPC: C12N15/09 , A61K38/00 , A61K39/395 , A61L27/22 , C07K14/705 , C07K14/75 , C07K14/78 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/00 , C12N5/06 , C12P21/02 , C12P21/08 , C12R1/91 , C12N15/00 , C07K7/00 , C07K13/00 , C07K15/28 , C12N15/63 , G01N33/53
CPC classification number: A61L27/227 , A61K38/00 , C07K14/75 , C07K14/78 , C07K16/18 , C07K2319/00 , C07K2319/24 , C07K2319/33 , C07K2319/50 , C07K2319/61
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4.METHODS AND COMPOSITIONS FOR INHIBITING ENDOTHELIAL CELL AND FIBRINOGEN MEDIATED INFLAMMATION. 失效
Title translation: 用于预防炎症内皮和纤维蛋白原的方法和组合物所产生。公开(公告)号:EP0644768A4
公开(公告)日:1997-06-11
申请号:EP93916500
申请日:1993-06-11
Applicant: SCRIPPS RESEARCH INST
Inventor: LANGUINO LUCIA R , ALTIERI DARIO C , PLOW EDWARD F , GELTOSKY JOHN E
IPC: A61K38/00 , C07K14/705 , C07K14/75 , C07K16/28 , A61K38/16 , A61K39/395 , C07K7/00 , G01N33/53 , C07K15/28
CPC classification number: C07K14/70525 , A61K38/00 , C07K14/75 , C07K16/28
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5.-i(IN VITRO) METHODS FOR DETERMINING -i(IN VIVO) THROMBOTIC EVENTS. 失效
Title translation: 的体外方法,测定体内举行血栓事件。公开(公告)号:EP0583352A4
公开(公告)日:1995-06-14
申请号:EP92911047
申请日:1992-04-27
Applicant: SCRIPPS RESEARCH INST
Inventor: GINSBERG MARK H , FRELINGER ANDREW L III , PLOW EDWARD F
IPC: A61K38/00 , C07K14/705 , C07K16/28 , C12Q1/00 , G01N33/53
CPC classification number: C07K14/705 , A61K38/00 , A61K2039/505 , C07K16/2848 , C07K2317/34 , Y10S435/975 , Y10S436/808
Abstract: Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
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公开(公告)号:PT644768E
公开(公告)日:2002-03-28
申请号:PT93916500
申请日:1993-06-11
Applicant: SCRIPPS RESEARCH INST
Inventor: LANGUINO LUCIA R , ALTIERI DARIO C , PLOW EDWARD F , GELTOSKY JOHN E
IPC: A61K38/00 , C07K14/705 , C07K14/75 , C07K16/28 , A61K39/395 , C07K2/00 , C07K7/00 , G01N33/53
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公开(公告)号:PT619839E
公开(公告)日:2000-10-31
申请号:PT93900897
申请日:1992-12-04
Applicant: SCRIPPS RESEARCH INST
Inventor: GINSBERG MARK H , BOWDITCH RONALD , PLOW EDWARD F
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公开(公告)号:PT99676B
公开(公告)日:1999-05-31
申请号:PT9967691
申请日:1991-12-03
Applicant: SCRIPPS RESEARCH INST
Inventor: PLOW EDWARD F , GINSBERG MARK H , MCMILLAN ROBERT
IPC: C07K14/47 , C07K14/705 , C07K16/28
Abstract: A polypeptide consisting essentially of an amino acid residue sequence corresponding to a formula selected from the group consisting of: Tyr-His-Asp-Arg-Lys-Glu-Phe-Ala-Lys-Phe-Glu-Glu-Glu-Arg-Ala-Arg-Ala-Lys-Trp-Asp-Thr-Ala-Asn-Asn; and Ala-Asn-Asn-Pro-Leu-Tyr-Lys-Glu-Ala-Thr-Ser-Thr-Phe-Thr-Asn-Ile-Thr-Tyr-Arg-Gly-Thr.
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9.
公开(公告)号:AU675073B2
公开(公告)日:1997-01-23
申请号:AU4632793
申请日:1993-06-11
Applicant: SCRIPPS RESEARCH INST
Inventor: LANGUINO LUCIA R , ALTIERI DARIO C , PLOW EDWARD F , GELTOSKY JOHN E
IPC: A61K38/00 , C07K14/705 , C07K14/75 , C07K16/28 , C07K15/06 , A61K37/02 , A61K39/395 , C12P21/08 , G01N33/68
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公开(公告)号:NO930163L
公开(公告)日:1993-03-19
申请号:NO930163
申请日:1993-01-18
Applicant: SCRIPPS RESEARCH INST
Inventor: ALTIERI DARIO , PLOW EDWARD F , EDGINGTON THOMAS S
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