公开(公告)号：US20040235811A1

公开(公告)日：2004-11-25

申请号：US10681614

申请日：2003-10-08

Applicant: Sepracor Inc.

Inventor： Mark G. Currie ,  Steven Jones ,  Charles M. Zepp

IPC: A61K031/56 ,  C07J005/00

CPC classification number: C07J5/00 ,  C07J5/0076 ,  C07J5/0092 ,  C07J71/0031 ,  Y10S514/826 ,  Y10S514/886

Abstract: Compounds are disclosed of the formula 1 in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.

Abstract translation: 公开了下式的化合物，其中R 3为C 8至C 24烃或米索前列醇的残基。 该化合物可用于治疗鼻炎和哮喘，特别是通过吸入治疗和治疗炎症，特别是通过局部或局部给药治疗炎症。

公开(公告)号：US20030162825A1

公开(公告)日：2003-08-28

申请号：US10292368

申请日：2002-11-12

Applicant: SEPRACOR INC.

Inventor： Donald L. Heefner ,  Mark G. Currie ,  Richard Filip Rossi JR. ,  Charles M. Zepp

IPC: A61K031/473 ,  A61K031/404 ,  A61K031/401 ,  A61K031/34

CPC classification number: A61K31/34 ,  A61K31/401 ,  A61K31/404 ,  A61K31/405 ,  A61K31/473

Abstract: Methods and pharmaceutical compositions which inhibit the activity of D-amino acid oxidase (DAO) are disclosed. Inhibition of DAO improves memory, learning and cognition in individuals suffering from neurodegenerative diseases such as Alzheimer's, Huntington's or Parkinson's diseases; the methods and pharmaceutical compositions which inhibit the activity of DAO also improve cognitive dysfunctions associated with aging and improve catatonic schizophrenia. Several genera of heterocycle-2-carboxylic acids are disclosed as DAO inhibitors.

Abstract translation: 公开了抑制D-氨基酸氧化酶（DAO）活性的方法和药物组合物。 抑制DAO改善患有阿尔茨海默病，亨廷顿病或帕金森病等神经退行性疾病的个体的记忆，学习和认知; 抑制DAO活性的方法和药物组合物也改善与老化相关的认知功能障碍并改善紧张型精神分裂症。 公开了几种杂环-2-羧酸作为DAO抑制剂。