公开(公告)号：US20030100581A1

公开(公告)日：2003-05-29

申请号：US09907556

申请日：2001-07-17

Applicant: SEPRACOR INC.

Inventor： Roger P. Bakale ,  Chris Senanayake ,  Yaping Hong ,  Kostas Saranteas ,  Martin P. Redmon ,  Stephen A. Wald

IPC: A61K031/454 ,  C07D43/02

CPC classification number: C07D401/12

Abstract: Polymorphic crystalline forms of the antihistaminic drug norastemizole are disclosed. Processes for the production of the preferred polymorph are also disclosed.

Abstract translation: 公开了抗组胺药物诺尔阿司咪唑的多晶型形式。 还公开了制备优选多晶型物的方法。

公开(公告)号：US20020143016A1

公开(公告)日：2002-10-03

申请号：US10040475

申请日：2002-01-09

Applicant: Sepracor, Inc.

Inventor： Thomas P. Jerussi ,  Chrisantha H. Senanayake ,  Paul D. Rubin ,  Yaping Hong ,  Roger A. Bakale ,  Tingjian Xiang ,  Fran A. McConville

IPC: A61K031/4985

CPC classification number: A61K31/4985 ,  A61K31/498 ,  C07B2200/07 ,  C07D487/04

Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone.

公开(公告)号：US20020019398A1

公开(公告)日：2002-02-14

申请号：US09877103

申请日：2001-06-11

Applicant: SEPRACOR, Inc.

Inventor： Thomas P. Jerussi ,  Chrisantha H. Senanayake ,  Paul D. Rubin ,  Yaping Hong ,  Roger A. Bakale ,  Tingjian Xiang ,  Fran A. McConville

IPC: A61K031/4985

CPC classification number: A61K31/4985 ,  A61K31/498 ,  C07B2200/07 ,  C07D487/04

Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone.

公开(公告)号：US20030166657A1

公开(公告)日：2003-09-04

申请号：US10340957

申请日：2003-01-13

Applicant: Sepracor, Inc.

Inventor： Thomas P. Jerussi ,  Chrisantha H. Senanayake ,  Paul D. Rubin ,  Yaping Hong ,  Roger A. Bakale ,  Tingjian Xiang ,  Fran A. McConville

IPC: A61K031/724 ,  A61K031/498

CPC classification number: A61K31/4985 ,  A61K31/498 ,  C07B2200/07 ,  C07D487/04

Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone.

公开(公告)号：US20030119841A1

公开(公告)日：2003-06-26

申请号：US10259851

申请日：2002-09-30

Applicant: Sepracor, Inc.

Inventor： Thomas P. Jerussi ,  Chrisantha H. Senanayake ,  Paul D. Rubin ,  Yaping Hong ,  Roger A. Bakale ,  Tingjian Xiang ,  Fran A. McConville

IPC: A61K031/498

CPC classification number: A61K31/4985 ,  A61K31/498 ,  C07B2200/07 ,  C07D487/04

Abstract: The invention is directed to compositions comprising, and methods of using, racemic N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone in the treatment and prevention of diseases and conditions in mammals. The invention is further directed to novel methods of preparing N-desmethylzopiclone, optically pure (null)-N-desmethylzopiclone, and optically pure (null)-N-desmethylzopiclone.

Abstract translation: 本发明涉及包含外消旋的N-去甲基佐氮克隆，光学纯的（+） - N-去甲基佐匹克隆和光学纯的（ - ） - N-去甲基佐匹克隆的组合物，其用于治疗和预防哺乳动物的疾病和病症。 本发明进一步涉及制备N-去甲基异佐匹克隆，光学纯的（+） - N-去甲基佐匹克隆和光学纯的（ - ） - N-去甲基异佐匹克隆的新方法。