公开(公告)号：ES2187334B1

公开(公告)日：2004-09-16

申请号：ES200100105

申请日：2001-01-17

Applicant: SERVIER LAB

Inventor： MONGE VEGA ANTONIO ,  ALDANA MORAZA IGNACIO ,  CAIGNARD DANIEL-HENRI ,  LEVENS NIGEL ,  FELETOU MICHEL ,  DELLA ZUANA ODILE

IPC: A61P3/04 ,  C07C311/13 ,  C07C311/19 ,  C07D213/82 ,  C07D215/36 ,  C07D333/34 ,  C07C311/18 ,  A61K31/15 ,  A61K31/18 ,  C07C311/05

公开(公告)号：ES2161594B1

公开(公告)日：2003-04-01

申请号：ES9802626

申请日：1998-12-17

Applicant: SERVIER LAB

Inventor： MONGE VEGA ANTONIO ,  ALDANA MORAZA IGNACIO ,  CAIGNARD DANIEL-HENRI ,  DUHAULT JACQUES ,  BOUTIN JEAN ,  DELLA ZUANA ODILE

IPC: C07D239/26 ,  A61K31/16 ,  A61K31/401 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4406 ,  A61K31/505 ,  A61P3/04 ,  A61P43/00 ,  C07C241/04 ,  C07C243/00 ,  C07C243/34 ,  C07C243/38 ,  C07C269/06 ,  C07C271/22 ,  C07C303/40 ,  C07C311/13 ,  C07C311/18 ,  C07C311/19 ,  C07C311/29 ,  C07C311/42 ,  C07C311/45 ,  C07C311/49 ,  C07C317/14 ,  C07D207/16 ,  C07D207/48 ,  C07D209/18 ,  C07D209/42 ,  C07D213/87 ,  C07D213/88 ,  C07D215/36 ,  C07D239/30 ,  C07D333/34 ,  C07D401/12 ,  C07C311/46 ,  A61K31/15 ,  A61K31/18

Abstract: Hydrazide derivatives (I) are new. Hydrazide derivatives of formula (I) and their acid or base addition salts are new. n = 0 or 1; W' = -CO- or -S(O)r; r = 0-2; Z = aryl, aralkyl, heteroaryl or heteroaralkyl (all optionally substituted with 1-5 1-6C alkyl, 1-6c alkoxy, halo, OH, 1-6C perhalogenoalkyl, nitro, 1-6C acyl, 1-6C alkylsulfonyl or amino (optionally substituted with one or two 1-6C alkyl or 1-6C acyl)); R = Z-T-CO-, Z-O-T-CO-, Z-T-O-CO- or Z-T-S(O)r; T = bond, alkylene, alkenylene or alkynylene; A = 3-8C alkylene, 3-8C alkenylene, 3-8C alkynylene, alkylenecycloalkylene, cycloalkylenealkylene, alkylenecycloalkylenealkylene, alkylenearylene, arylenealkylene, alkylenearylenealkylene or a group of formula (i); or A = forms a group of formula (ii) with the adjacent N; B1 = Z; B2 = 5 to 11-membered (un)saturated mono- or bicyclic ring optionally comprising 1-3 N, O or S; alkyl, alkylene = 1-6C; alkenylene, alkynylene = 2-6C; aryl, arylene = phenyl, naphthyl, dihydronaphthyl or tetrahydronaphthyl; heteroaryl = unsaturated or partially unsaturated 5- to 11-membered mono- or bicyclic ring containing 1-4 N,O or S; cycloalkylene = 4-8C; and provided that when n is 0, A is (i), B1 is benzyl, Z is phenyl (optionally substituted), then R is other than benzoyl. Independent claims are also included for: (1) the preparation of (I); and (2) pharmaceutical compositions comprising at leas one compound (I).