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公开(公告)号：HK1020717A1
公开(公告)日：2000-05-19
申请号：HK99105660
申请日：1999-12-03
Applicant: SERVIER LAB
Inventor： RENARD PIERRE , LEFOULON FRANCOIS , DEMUYNCK LUC , LESIEUR DANIEL , DEPREUX PATRICK , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE
IPC: A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/22 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20 , C07C , C07D , A61K
Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.
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公开(公告)号：PT919541E
公开(公告)日：2005-11-30
申请号：PT98402963
申请日：1998-11-27
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , LEFOULON FRANCOIS , DEMUYNCK LUC , DEPREUX PATRICK , DELAGRANGE PHILIPPE , RENARD PIERRE , CAROLINE BENNEJEAN
IPC: A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/22 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20
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公开(公告)号：AU757436B2
公开(公告)日：2003-02-20
申请号：AU9421398
申请日：1998-11-27
Applicant: SERVIER LAB
Inventor： RENARD PIERRE , LEFOULON FRANCOIS , DEMUYNCK LUC , LESIEUR DANIEL , DEPREUX PATRICK , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE
IPC: A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/22 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20 , C07C233/13 , A61K31/275 , C07C233/11 , C07C233/40 , C07C233/51 , C07C255/60 , C07C275/10 , C07C309/76 , C07D333/22 , C07D333/24
Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.
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公开(公告)号：CY2160B1
公开(公告)日：2002-08-23
申请号：CY0000003
申请日：2000-03-01
Applicant: SERVIER LAB
Inventor： BRION JEAN-DANIEL , THAL CLAUDE , DEMUYNCK LUC , PARMENTIER JEAN-GILLES , LEPAGNOL JEAN , LESTAGE PIERRE , PUJOL JEAN-FRANCOIS , SCHMITT PASCAL , POTIER PIERRE
IPC: C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , A61K31/495
Abstract: Compounds of general formula (I): in which A represents a divalent radical chosen from and R1, R2, R3, R4, R5, R6, R7, R8, R9 and Z are as defined in the description. Medicaments.
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公开(公告)号：AU9421398A
公开(公告)日：1999-06-17
申请号：AU9421398
申请日：1998-11-27
Applicant: SERVIER LAB
Inventor： RENARD PIERRE , LEFOULON FRANCOIS , DEMUYNCK LUC , LESIEUR DANIEL , DEPREUX PATRICK , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE
IPC: A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/22 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20 , C07C233/13 , C07C233/11 , C07C233/40 , C07C233/51 , C07C309/76 , C07C275/10 , C07C255/60 , C07D333/22 , C07D333/24 , A61K31/275
Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.
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Patent Agency Ranking
公开(公告)号：ES2247668T3
公开(公告)日：2006-03-01
申请号：ES98402963
申请日：1998-11-27
Applicant: SERVIER LAB
Inventor： LEFOULON FRANCOIS , DEMUYNCK LUC , LESIEUR DANIEL , DEPREUX PATRICK , BENNEJEAN CAROLINE , RENARD PIERRE
IPC: A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/22 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20
Abstract: COMPUESTO DE FORMULA (I): EN LA QUE: - T REPRESENTA UNA CADENA ALQUILENO, . A Y B FORMAN JUNTOS UN GRUPO NAFTALENO, DIHIDRONAFTALENO O TETRAHIDRONAFTALENO, . R REPRESENTA UN HIDROGENO, UN GRUPO HIDROXI, R'' O OR'', ESTANDO R'' DEFINIDO COMO EN LA DESCRIPCION, . G 1 REPRESENTA UN HALOGENO, UN RADICAL R SUB,1 UN GRUPO - O - CO - R 1 , ESTANDO R 1 DEFINIDO COMO EN LA DESCRIPCION, . G 2 REPRESENTA UN GRUPO ELEGIDO ENTRE: ESTANDO X, R 2 Y R 21 DEFINIDOS COMO EN LA DESCRIPCION. MEDICAMENTOS.
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公开(公告)号：AU8038794A
公开(公告)日：1995-02-23
申请号：AU8038794
申请日：1994-12-12
Applicant: SERVIER LAB
Inventor： BRION JEAN-DANIEL , THAL CLAUDE , DEMUYNCK LUC , PARMENTIER JEAN-GILLES , LEPAGNOL JEAN , LESTAGE PIERRE , PUJOL JEAN-FRANCOIS , SCHMITT PASCAL , POTIER PIERRE
IPC: C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , C07D491/22 , A61K31/445 , A61K31/50
Abstract: Compounds of general formula (I): in which A represents a divalent radical chosen from and R1, R2, R3, R4, R5, R6, R7, R8, R9 and Z are as defined in the description. Medicaments.
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公开(公告)号：FR2977892B1
公开(公告)日：2013-07-26
申请号：FR1102213
申请日：2011-07-13
Applicant: SERVIER LAB , CENTRE NAT RECH SCIENT
Inventor： LEPAPE ALAIN , LERONDEL STEPHANIE , REVEILLON GUILLAUME , DELBOS JEAN MARIE , DEMUYNCK LUC , GRANDON HUBERT , LEFOULON FRANCOIS , TUCKER GORDON
IPC: C07D401/14 , A61K49/00 , C07D209/60 , C07D213/74 , G01N33/533
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公开(公告)号：FR2977892A1
公开(公告)日：2013-01-18
申请号：FR1102213
申请日：2011-07-13
Applicant: SERVIER LAB , CENTRE NAT RECH SCIENT
Inventor： LEPAPE ALAIN , LERONDEL STEPHANIE , REVEILLON GUILLAUME , DELBOS JEAN MARIE , DEMUYNCK LUC , GRANDON HUBERT , LEFOULON FRANCOIS , TUCKER GORDON
IPC: C07D401/14 , A61K49/00 , C07D209/60 , C07D213/74 , G01N33/533
Abstract: Composés de formule (I) : dans laquelle : ? R représente un groupement alkyle (C -C ) linéaire ou ramifié, ? L représente un groupement espaceur, ? A représente un agent diagnostique, ? m est égal à 1 ou 2, Agents d'imagerie.
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公开(公告)号：DE69831121T2
公开(公告)日：2006-06-14
申请号：DE69831121
申请日：1998-11-27
Applicant: SERVIER LAB
Inventor： LEFOULON FRANCOIS , DEMUYNCK LUC , LESIEUR DANIEL , DEPREUX PATRICK , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/22 , A61K31/00 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61P25/20 , A61P43/00 , C07C233/05 , C07C233/17 , C07C233/18 , C07C233/31 , C07C233/36 , C07C233/47 , C07C233/58 , C07C233/60 , C07C255/66 , C07C275/24 , C07C309/65 , C07C317/14 , C07C317/22 , C07C317/32 , C07C327/42 , C07C335/06 , C07D213/56 , C07D233/60 , C07D307/12 , C07D307/52 , C07D307/54 , C07D333/16 , C07D333/20
Abstract: Naphthalenic compounds (I), their enantiomers, diastereoisomers, and salts with acids and bases. The naphthalenic compounds are of formula (I) A and B' rings = naphthalene, 1,2-dihydronaphthalene, 2,3- dihydronaphthalene, 1,4- dihydronaphthalene, or tetrahydronaphthalene; T = 1-6C alkylene which may be substituted by one or more 1-6C alkyl, alkoxy, alkoxycarbonyl, OH, or COOH groups; R = H, OH, R', or OR'; R' = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, 4-7C cycloalkenyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted), or 1-6C trihaloalkyl sulfonyl; R may further link with two atoms of ring A and = a 5-7 membered saturated or unsaturated O-containing ring, which may be substituted by 1-6C alkyl, alkoxy, alkoxy-carbonyl, OH, or oxo; G1 = halo (in which case it is linked to ring B'), 1-6C trihalo alkyl sulfonyloxy, COOH, formyl, CN, R1 or -O-CO-R1; R1 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted); G2 = a group G20, G21, or G22; X = O or S; R2 = H or 1-6C alkyl; R21 = 1-6C alkyl, 2-6C alkenyl or alkynyl, 3-7C cycloalkyl, aryl, biphenyl, or heteroaryl (these groups being optionally substituted) with various provisos listed in the Definitions section.
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