公开(公告)号：UA93190C2

公开(公告)日：2011-01-25

申请号：UAA200707268

申请日：2007-06-27

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  SABAOUNI AHMED ,  PERES BASILE ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C15/24 ,  A61K31/165 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  C07C233/18

公开(公告)号：MY142817A

公开(公告)日：2011-01-14

申请号：MYPI20070960

申请日：2007-06-14

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/18

Abstract: COMPOUNDS OF FORMULA (I): MEDICAMENTS.

公开(公告)号：SI1873140T1

公开(公告)日：2009-12-31

申请号：SI200730089

申请日：2007-06-29

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/00 ,  A61K31/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

公开(公告)号：MX2007007899A

公开(公告)日：2009-02-16

申请号：MX2007007899

申请日：2007-06-27

Applicant: SERVIER LAB

Inventor： CAIGNARD DANIEL-HENRI ,  DELAGRANGE PHILIPPE ,  MILLAN MARK ,  YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL

IPC: A61K31/00 ,  C07C233/17

Abstract: La presente invención describe compuestos de fórmula (ver fórmula (I)). Medicamentos.

公开(公告)号：NZ556189A

公开(公告)日：2008-11-28

申请号：NZ55618907

申请日：2007-06-28

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD HANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/18 ,  C07C231/06 ,  A61K31/17 ,  C07C233/05 ,  C07C233/20 ,  C07C233/60 ,  A61K31/16

Abstract: 2-fluoro-N-[3-hydroxy-2-(7-methoxy-1-naphthyl)propyl]acetamide of formula (I), its enantiomers, and addition salts thereof with a pharmaceutically acceptable base are disclosed. These compounds are suitable for treating disorders of the melatoninergic system, wherein the disorder is selected form sleep disorders, stress, anxiety, major depression or seasonal affective disorder, cardiovascular pathologies, pathologies of the digestive system, insomnia and fatigue due to jetlag, schizophrenia, panic attacks, melancholia, appetite disorders, obesity, insomnia, psychotic disorders, epilepsy, diabetes, Parkinson's disease, senile dementia, various disorders associated with normal or pathological aging, migraine, memory loss, Alzheimer's disease, cerebral circulation disorders or sexual dysfunctions, as ovulation-inhibitors or immunomodulators, or for the treatment of cancers.

公开(公告)号：NZ556188A

公开(公告)日：2008-11-28

申请号：NZ55618807

申请日：2007-06-28

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD HANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/18 ,  C07C231/06 ,  A61K31/17 ,  C07C233/05 ,  C07C233/20 ,  C07C233/60 ,  A61K31/16

Abstract: N-[3-hydroxy-2-(7-methoxy-1-naphthyl)propyl]propanamide of formula (I), its enantiomers, and addition salts thereof with a pharmaceutically acceptable base are disclosed. These compounds are suitable for treating disorders of the melatoninergic system, wherein the disorder is selected form sleep disorders, stress, anxiety, major depression or seasonal affective disorder, cardiovascular pathologies, pathologies of the digestive system, insomnia and fatigue due to jetlag, schizophrenia, panic attacks, melancholia, appetite disorders, obesity, insomnia, psychotic disorders, epilepsy, diabetes, Parkinson's disease, senile dementia, various disorders associated with normal or pathological aging, migraine, memory loss, Alzheimer's disease, cerebral circulation disorders or sexual dysfunctions, as ovulation-inhibitors or immunomodulators, or for the treatment of cancers.

公开(公告)号：BRPI0702817A

公开(公告)日：2008-02-19

申请号：BRPI0702817

申请日：2007-06-29

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL HENRI ,  MILLAN MARK

IPC: C07C233/22 ,  A61K31/165 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  C07C231/06

Abstract: N-[3-Hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide (I), its enantiomers and base addition salts, are new. N-[3-Hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide of formula (I), its enantiomers and base addition salts, are new. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Cerebroprotective; Contraceptive; Endocrine-Gen; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The ability of (I) to bind with melatonin was tested. The results showed that N-[3-hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide exhibited an inhibition constant value of 1.4 nM and 3.2 nM to bind with melatonin receptors MT 1 and MT 2, respectively.

公开(公告)号：CA2593621A1

公开(公告)日：2007-12-30

申请号：CA2593621

申请日：2007-06-29

Applicant: SERVIER LAB

Inventor： MILLAN MARK ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  PERES BASILE ,  YOUS SAID ,  SPEDDING MICHAEL ,  BERTHELOT PASCAL ,  SABAOUNI AHMED

IPC: C07C233/18 ,  A61K31/165 ,  C07C231/02 ,  C07C231/20

Abstract: Composés de formule (I) : (voir formule I) Médicaments.

公开(公告)号：RS51079B

公开(公告)日：2010-10-31

申请号：RSP20090502

申请日：2007-06-29

Applicant: SERVIER LAB

Inventor： MILLAN MARK ,  BERTHELOT PASCAL ,  CAIGNARD DANIEL-HENRI ,  YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE

IPC: C07C233/18 ,  A61K31/165 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02

Abstract: Jedinjenje formule (I):ili N-[3-hidroksi-2-(7-metoksi-1-naftil)propil]propanamid, njegovi enantiomeri, kao i njihove adicione soli sa farmaceutski prihvatljivom bazom.Prijava sadrži još 6 zavisnih patentnih zahteva.

公开(公告)号：FR2903103B1

公开(公告)日：2010-08-13

申请号：FR0605918

申请日：2006-06-30

Applicant: SERVIER LAB

Inventor： YOUS SAID ,  PERES BASILE ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL HENRI ,  MILLAN MARK

IPC: C07C235/34 ,  A61K31/165 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02