公开(公告)号：JP2003096057A

公开(公告)日：2003-04-03

申请号：JP2002205661

申请日：2002-07-15

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which is useful for prevention or treatment of cellular ischemia, ischemic brain, ischemic heart or peripheral ischemia; treatment of chronic neurodegenerative symptoms, and for storage of organs for the purpose of transplantation, as well as for improving recovery of functioning transplant piece of after being reperfused. SOLUTION: An N-benzylpiperazine compound is represented by formula (I), [wherein, R1 is a straight chain or branched chain (C1 -C6 ) alkyl group; R2 is a hydroxyl group or the like; R3 is a hydrogen atom or the like; n is an integer of 1 to 12], and an optical isomer thereof, an addition salt thereof with a pharmaceutically acceptable acid or base, and a method for preparing thereof, as well as a pharmaceutical composition containing said compound are provided.

公开(公告)号：FR2827284B1

公开(公告)日：2003-10-31

申请号：FR0109454

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  C07D295/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D241/04

Abstract: The present invention relates to a compound selected from those of formula (I):wherein:R1 represents alkyl,R2 represents hydroxy, alkoxy, or amino,n represents an integer from 1 to 12 inclusive,R3 represents:hydrogen, optionally substituted alkyl, cycloalkyl, pyrimidinyl or optionally substituted phenyl,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the prevention or treatment of acute and chronic cell ischaemia.

公开(公告)号：FR2827284A1

公开(公告)日：2003-01-17

申请号：FR0109454

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  C07D295/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D241/04

Abstract: N-Benzyl piperazine derivatives (I), their isomers, and salts with acids and bases. N-Benzyl piperazine derivatives (I), their isomers, and salts with acids and bases. R1 = 1-6C alkyl; R2 = OH, 1-6C alkoxy, amino, 1-6C alkylamino or di(1-6C)alkylamino; n = 1 - 12; and R3 = H, 1-12C alkyl (optionally substituted by phenyl itself optionally substituted by one or more halogens, hydroxy, 1-6C alkyl or alkoxy, or trihalomethyl, or 3-7C cycloalkyl), 3-7C cycloalkyl, pyrimidinyl, phenyl (optionally substituted by one or more halogens, hydroxy, 1-6C alkyl or alkoxy) or trihalomethyl.