公开(公告)号：JP2003096057A

公开(公告)日：2003-04-03

申请号：JP2002205661

申请日：2002-07-15

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which is useful for prevention or treatment of cellular ischemia, ischemic brain, ischemic heart or peripheral ischemia; treatment of chronic neurodegenerative symptoms, and for storage of organs for the purpose of transplantation, as well as for improving recovery of functioning transplant piece of after being reperfused. SOLUTION: An N-benzylpiperazine compound is represented by formula (I), [wherein, R1 is a straight chain or branched chain (C1 -C6 ) alkyl group; R2 is a hydroxyl group or the like; R3 is a hydrogen atom or the like; n is an integer of 1 to 12], and an optical isomer thereof, an addition salt thereof with a pharmaceutically acceptable acid or base, and a method for preparing thereof, as well as a pharmaceutical composition containing said compound are provided.

公开(公告)号：FR2827284A1

公开(公告)日：2003-01-17

申请号：FR0109454

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  C07D295/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D241/04

Abstract: N-Benzyl piperazine derivatives (I), their isomers, and salts with acids and bases. N-Benzyl piperazine derivatives (I), their isomers, and salts with acids and bases. R1 = 1-6C alkyl; R2 = OH, 1-6C alkoxy, amino, 1-6C alkylamino or di(1-6C)alkylamino; n = 1 - 12; and R3 = H, 1-12C alkyl (optionally substituted by phenyl itself optionally substituted by one or more halogens, hydroxy, 1-6C alkyl or alkoxy, or trihalomethyl, or 3-7C cycloalkyl), 3-7C cycloalkyl, pyrimidinyl, phenyl (optionally substituted by one or more halogens, hydroxy, 1-6C alkyl or alkoxy) or trihalomethyl.

公开(公告)号：CA2394010A1

公开(公告)日：2003-01-16

申请号：CA2394010

申请日：2002-07-16

Applicant: SERVIER LAB

Inventor： CECCHELLI ROMEO ,  SPEDDING MICHAEL ,  HARPEY CATHERINE ,  SCHENKER ESTHER ,  LE RIDANT ALAIN ,  TILLEMENT JEAN-PAUL ,  LABIDALLE SERGE ,  TESTA BERNARD

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D403/04 ,  C07D241/04

公开(公告)号：AR034779A1

公开(公告)日：2004-03-17

申请号：ARP020102635

申请日：2002-07-15

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN-PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D403/04

Abstract: Compuestos de la fórmula (1) en la cual R1 representa un grupo alquilo (C1-6) lineal o ramificado, R2 representa un grupo hidroxi, alcoxi, (C1-6) lineal o ramificado, o amino (opcionalmente sustituido por uno o dos grupos alquilo (C1-6) lineal o ramificado), n representa un número entero comprendido entre 1 y 12 inclusive, R3 representa: un átomo de hidrógeno, un grupo alquilo (C1-12) lineal o ramificado opcionalmente sustituido por un grupo fenilo (este a su vez opcionalmente sustituido por uno o varios, idénticos o diferentes seleccionados entre átomos de halógeno y grupos alquilo (C1-6) lineal o ramificado, alcoxi (C1-6) lineal o ramificado, hidroxi y trihalometilo), un grupo cicloalquilo (C3-7), un grupo cicloalquilo (C3-7), un grupo carboxi o un grupo alcoxi (C1-6)-carbonilo, un grupo pirimidinilo opcionalmente sustituido por uno o dos grupos pirrolidinilo, o un grupo fenilo opcionalmente sustituido por uno o varios sustituyentes idénticos o diferentes seleccionados entre átomos de halógeno y grupos alquilo (C1-6) lineal o ramificado, alcoxi C1-6 lineal o ramificado, hidroxi y trihalometilo, sus isómeros ópticos y las sales de adición de los mismos, con un ácido o con una base farmacéuticamente aceptable. Procedimiento para prepararlos y composiciones farmacéuticas que los comprenden. Los compuestos de fórmula 1 son útiles, para inter alia, para la prevención o el tratamiento de la isquemia celular aguda y crónica, los accidentes isquémicos agudos o crónicos, cerebrales, cardíacos o periféricos seguidos o no de reperfusión, antes de cualquier intervención quirúrgica que requiera una detención transitoria de la circulación sanguínea, para el tratamiento de enfermedades neurodegenerativas crónicas, y para mejorar la conservación de órganos destinados a ser trasplantados y la recuperación funcional de los injertos después de una reperfusión.

公开(公告)号：AU4842297A

公开(公告)日：1998-06-18

申请号：AU4842297

申请日：1997-12-16

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  LABIDALLE SERGE ,  GUYOT DANIEL ,  ROLLAND YVES ,  TILLEMENT JEAN-PAUL ,  TESTA BERNARD ,  CREVAT AIMEE

IPC: C07D295/08 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/495 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00 ,  C07D213/74 ,  C07D213/80 ,  C07D213/81 ,  C07D295/096 ,  C07D295/185 ,  C07D311/58 ,  C07D311/66 ,  C07D311/72 ,  C07D339/04 ,  C07D241/04 ,  A61K31/35 ,  A61K31/40

Abstract: N-benzyl piperazine derivatives of formula (I), their isomers and addition salts with acids and bases are new. R1 = 1-6 C alkyl; X = O or S; R2 = 1-8 C alkyl (optionally substituted by CO2H or 1-6C alkoxycarbonyl), 1-6C alkoxy, phenyl (optionally substituted by halo, 1-6C alkyl or alkoxy, OH or trihalomethyl), 3-7C cycloalkyl (optionally substituted by ≥ 1 phenyl (optionally substituted by ≥ 1 halo or 1-6C alkyl or alkoxy, OH or trihalomethyl)), 4-(2,3-dithiacyclopent-1-yl)-butyl, pyridyl, NH2 (optionally mono- or di-alkylated with 1-6C alkyl), or a chroman or chroman-alkyl group; and R3 = H, 3-7C cycloalkyl, CHO, phenyl (optionally substituted by halo, 1-6C alkyl or alkoxy, OH or trihalomethyl), pyridyl or 1-20 C alkyl (optionally substituted by ≥ 1 halo, phenyl or cycloalkyl (optionally substituted as described above as in R2)), 1-6C alkoxy, OH or pyrrolidinyl.

公开(公告)号：DE60204083T2

公开(公告)日：2006-03-16

申请号：DE60204083

申请日：2002-07-16

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN-PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15

Abstract: The present invention relates to a compound selected from those of formula (I):wherein:R1 represents alkyl,R2 represents hydroxy, alkoxy, or amino,n represents an integer from 1 to 12 inclusive,R3 represents:hydrogen, optionally substituted alkyl, cycloalkyl, pyrimidinyl or optionally substituted phenyl,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the prevention or treatment of acute and chronic cell ischaemia.

公开(公告)号：AT295358T

公开(公告)日：2005-05-15

申请号：AT02291784

申请日：2002-07-16

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN-PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15

Abstract: The present invention relates to a compound selected from those of formula (I):wherein:R1 represents alkyl,R2 represents hydroxy, alkoxy, or amino,n represents an integer from 1 to 12 inclusive,R3 represents:hydrogen, optionally substituted alkyl, cycloalkyl, pyrimidinyl or optionally substituted phenyl,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the prevention or treatment of acute and chronic cell ischaemia.

公开(公告)号：EA005165B1

公开(公告)日：2004-12-30

申请号：EA200200682

申请日：2002-07-15

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN-PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  RIDANT ALAIN LE ,  HAPPEY CATHIRINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  C07D295/08 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15

Abstract: Настоящееизобретениеотноситсяк соединениямформулы (I)вкоторой Rпредставляетсобойалкильнуюгруппу, Rпредставляетсобойгидрокси, алкокси, илиаминогруппу, n представляетсобойкоэффициентот 1 до 12 включительно, Rпредставляетсобойатомводорода, необязательнозамещеннуюалкильнуюгруппу, циклоалкильнуюгруппу, пиримидинильнуюгруппуилинеобязательнозамещеннуюфенильнуюгруппу, ихизомерами аддитивнымсолямс фармацевтическиприемлемойкислотойилиоснованием. Лекарственныепрепараты.

公开(公告)号：FR2827284B1

公开(公告)日：2003-10-31

申请号：FR0109454

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： LABIDALLE SERGE ,  TILLEMENT JEAN PAUL ,  TESTA BERNARD ,  CECCHELLI ROMEO ,  LE RIDANT ALAIN ,  HARPEY CATHERINE ,  SPEDDING MICHAEL ,  SCHENKER ESTHER

IPC: A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  C07D295/08 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D241/04

Abstract: The present invention relates to a compound selected from those of formula (I):wherein:R1 represents alkyl,R2 represents hydroxy, alkoxy, or amino,n represents an integer from 1 to 12 inclusive,R3 represents:hydrogen, optionally substituted alkyl, cycloalkyl, pyrimidinyl or optionally substituted phenyl,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the prevention or treatment of acute and chronic cell ischaemia.

公开(公告)号：AU2002300150B2

公开(公告)日：2007-10-11

申请号：AU2002300150

申请日：2002-07-16

Applicant: SERVIER LAB

Inventor： CECCHELLI ROMEO ,  HARPEY CATHERINE ,  TESTA BERNARD ,  LABIDALLE SERGE ,  SPEDDING MICHAEL ,  RIDANT ALAIN LE ,  SCHENKER ESTHER ,  TILLEMENT JEAN-PAUL

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61P9/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/28 ,  A61P41/00 ,  C07D239/42 ,  C07D239/50 ,  C07D295/03 ,  C07D295/092 ,  C07D295/096 ,  C07D295/14 ,  C07D295/15 ,  C07D403/04

Abstract: The present invention relates to a compound selected from those of formula (I):wherein:R1 represents alkyl,R2 represents hydroxy, alkoxy, or amino,n represents an integer from 1 to 12 inclusive,R3 represents:hydrogen, optionally substituted alkyl, cycloalkyl, pyrimidinyl or optionally substituted phenyl,its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, medicinal products containing the same are useful in the prevention or treatment of acute and chronic cell ischaemia.