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    Method and device for acquiring biomechanical parameters based on ultrasonic elastomyogram
    1.
    发明授权
    Method and device for acquiring biomechanical parameters based on ultrasonic elastomyogram 有权

    公开(公告)号：US11452502B2

    公开(公告)日：2022-09-27

    申请号：US16482802

    申请日：2017-12-26

    Applicant: Shenzhen Institutes of Advanced Technology

    Inventor： Yang Xiao ,  Hairong Zheng ,  Congzhi Wang ,  Lili Niu ,  Zhiting Deng

    IPC: A61B8/08

    Abstract: A method and a device for acquiring biomechanical parameters based on an ultrasonic elastomyogram are provided, wherein the method includes: synchronously collecting a dynamic myodynamics image sequence and a dynamic elasticity image sequence of a single skeletal muscle under continuous stretching; acquiring a myodynamics parameter corresponding to each myodynamics image in the dynamic myodynamics image sequence and an elasticity modulus value corresponding to each elasticity image in the dynamic elasticity image sequence respectively; and generating an ultrasonic elastomyogram curve with the myodynamics parameter as the abscissa and the synchronized elasticity modulus value as the ordinate, and estimating a muscle biomechanical parameter based on the ultrasonic elastomyogram curve. Dynamically changing biomechanical parameters can be obtained, and the obtained muscle biomechanical parameters have relatively high accuracy.

    MICROFLUIDIC CHIP, APPARATUS, SYSTEM, AND CONTROL AND PREPARATION METHOD THEREFOR
    2.
    发明申请
    MICROFLUIDIC CHIP, APPARATUS, SYSTEM, AND CONTROL AND PREPARATION METHOD THEREFOR 审中-公开

    公开(公告)号：US20200316585A1

    公开(公告)日：2020-10-08

    申请号：US16903415

    申请日：2020-06-17

    Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

    Inventor： LONG MENG ,  Hairong Zheng ,  Kaiyue Wang ,  Wei Zhou ,  Lili Niu ,  Xiaowei Huang

    IPC: B01L3/00

    Abstract: A microfluidic chip (100), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (101), and an electrode layer (102) and a functional layer (103) sequentially formed on the substrate (101), said electrode layer (102) comprising a plurality of electrode groups (1021) arranged in an array, the electrode groups (1021) being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (103); and the functional layer (103) being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group (1021) and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group (1021).

    Ultrasonic wake-up system
    3.
    发明授权
    Ultrasonic wake-up system 有权

    公开(公告)号：US12257458B2

    公开(公告)日：2025-03-25

    申请号：US18325982

    申请日：2023-05-30

    Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

    Inventor： Hairong Zheng ,  Wei Zhou ,  Long Meng ,  Lili Niu ,  Zhengrong Lin ,  Xiaowei Huang ,  Junjie Zou

    IPC: A61N7/00 ,  A61B8/00 ,  A61B8/08

    Abstract: The present application provides an ultrasonic wake-up system. The system includes an ultrasonic imaging device, an ultrasound stimulation device, and an ultrasound stimulation effect evaluation device, and acquires an ultrasonic image of a target object through the ultrasonic imaging device, transmits an ultrasound to the target object based on the ultrasonic image through the ultrasound stimulation device, and adjusts the transmitted ultrasound required through the ultrasound stimulation effect evaluation device. Therefore, peripheral nerves are accurately stimulated, an uplink reticular wake-up system is activated, so as to wake up patients with disorders of consciousness.

    Microfluidic chip, apparatus, system, and control and preparation method therefor
    6.
    发明授权
    Microfluidic chip, apparatus, system, and control and preparation method therefor 有权

    公开(公告)号：US11433392B2

    公开(公告)日：2022-09-06

    申请号：US16903415

    申请日：2020-06-17

    Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

    Inventor： Long Meng ,  Hairong Zheng ,  Kaiyue Wang ,  Wei Zhou ,  Lili Niu ,  Xiaowei Huang

    IPC: B01L3/00

    Abstract: A microfluidic chip (100), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (101), and an electrode layer (102) and a functional layer (103) sequentially formed on the substrate (101), said electrode layer (102) comprising a plurality of electrode groups (1021) arranged in an array, the electrode groups (1021) being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (103); and the functional layer (103) being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group (1021) and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group (1021).

    CONSCIOUS ANIMAL ULTRASONIC NEURAL REGULATION DEVICE
    8.
    发明申请
    CONSCIOUS ANIMAL ULTRASONIC NEURAL REGULATION DEVICE 审中-公开

    公开(公告)号：US20200038692A1

    公开(公告)日：2020-02-06

    申请号：US16492405

    申请日：2017-04-21

    Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

    Inventor： Hairong Zheng ,  Hui Zhou ,  Lili Niu ,  Ruibiao Guo ,  Long Meng ,  Yongchuan Li ,  Min Su ,  Jiquing Huang ,  Ming Qian

    IPC: A61N7/00 ,  B06B1/02 ,  B06B1/06

    Abstract: Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.

    BIOLOGICAL SAMPLE SORTING METHOD, SURFACE ACOUSTIC WAVE MICROFLUIDIC CHIP, SYSTEM, TERMINAL, AND STORAGE MEDIUM
    9.
    发明公开
    BIOLOGICAL SAMPLE SORTING METHOD, SURFACE ACOUSTIC WAVE MICROFLUIDIC CHIP, SYSTEM, TERMINAL, AND STORAGE MEDIUM 审中-公开

    公开(公告)号：US20230151313A1

    公开(公告)日：2023-05-18

    申请号：US18098701

    申请日：2023-01-19

    Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

    Inventor： HAIRONG ZHENG ,  Long Meng ,  Weixing Chen ,  Lili Niu ,  Xiaoyu Cui

    IPC: C12M1/42 ,  G06N3/045 ,  G06T7/20

    CPC classification number: C12M1/42 ,  G06N3/045 ,  G06T7/20

    Abstract: A biological sample sorting method, a surface acoustic wave microfluidic chip, a system, a terminal, and a storage medium are disclosed. The method includes: injecting a mixed solution containing biological samples into a surface acoustic wave microfluidic chip, and applying a first sinusoidal signal thereto forming a standing wave sound field therein to aggregate the biological samples; collecting images of the aggregated biological samples; performing moving target identification and tracking on the images of the biological samples using a deep learning model, performing cluster analysis and classification on a tracked moving target to obtain a target sample, and generating a delay enabling signal of the target sample according to a moving speed of the target sample; and applying a second sinusoidal signal to the surface acoustic wave microfluidic chip according to the delay enable signal to move the target sample thus sorting out the target sample.

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