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公开(公告)号：US12121897B2
公开(公告)日：2024-10-22
申请号：US16769103
申请日：2018-12-21
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Hairong Zheng , Fei Li , Feiyan Cai , Long Meng , Yang Xiao , Fei Yan
CPC classification number: B01L3/502753 , B06B1/06 , B01L2400/0409 , B01L2400/0436 , B82Y35/00
Abstract: A microfluidic system, including: a container, an ultrasound transmitter assembly, and a phononic crystal plate. The container is configured to accommodate a solution containing microparticles. The ultrasound transmitter assembly is configured to transmit ultrasonic waves to the phononic crystal plate, where the ultrasonic waves have a frequency which is the same as a resonance frequency of the phononic crystal plate. The phononic crystal plate is placed in the solution, and configured to generate a local acoustic field on a surface of the phononic crystal plate under excitation of the ultrasonic waves, and induce an acoustic microstreaming vortex to generate an acoustic streaming shear stress on the microparticles. The phononic crystal plate defines therein cavities, the respective cavities are arranged periodically in the phononic crystal plate, and all the respective cavities are filled with gas.
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公开(公告)号：US12257458B2
公开(公告)日：2025-03-25
申请号：US18325982
申请日：2023-05-30
Inventor： Hairong Zheng , Wei Zhou , Long Meng , Lili Niu , Zhengrong Lin , Xiaowei Huang , Junjie Zou
Abstract: The present application provides an ultrasonic wake-up system. The system includes an ultrasonic imaging device, an ultrasound stimulation device, and an ultrasound stimulation effect evaluation device, and acquires an ultrasonic image of a target object through the ultrasonic imaging device, transmits an ultrasound to the target object based on the ultrasonic image through the ultrasound stimulation device, and adjusts the transmitted ultrasound required through the ultrasound stimulation effect evaluation device. Therefore, peripheral nerves are accurately stimulated, an uplink reticular wake-up system is activated, so as to wake up patients with disorders of consciousness.
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公开(公告)号：US20200338548A1
公开(公告)日：2020-10-29
申请号：US16606355
申请日：2017-01-03
Inventor： Hairong Zheng , Wei Zhou , Long Meng , Lili Niu , Zhengrong Lin , Kaiyue Wang , Xiaowei Huang
Abstract: Provided are a microfluidic apparatus, a method and system for introducing a substance into a cell. The microfluidic apparatus includes a cavity channel, a bulk wave generating device and a surface acoustic wave generating device; a microstructure is arranged on an inner wall of the cavity channel, and the microstructure is constructed for forming a bubble by a solution at the microstructure when the solution is injected into the cavity channel; the bulk wave generating device is configured to generate a bulk wave, the bulk wave enables the bubble to resonate for generating a flow field; and the surface acoustic wave generating device is configured to generate a surface acoustic wave and control a position of at least one particle in the solution.
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4.发明公开公开(公告)号：US20230151313A1
公开(公告)日：2023-05-18
申请号：US18098701
申请日：2023-01-19
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： HAIRONG ZHENG , Long Meng , Weixing Chen , Lili Niu , Xiaoyu Cui
Abstract: A biological sample sorting method, a surface acoustic wave microfluidic chip, a system, a terminal, and a storage medium are disclosed. The method includes: injecting a mixed solution containing biological samples into a surface acoustic wave microfluidic chip, and applying a first sinusoidal signal thereto forming a standing wave sound field therein to aggregate the biological samples; collecting images of the aggregated biological samples; performing moving target identification and tracking on the images of the biological samples using a deep learning model, performing cluster analysis and classification on a tracked moving target to obtain a target sample, and generating a delay enabling signal of the target sample according to a moving speed of the target sample; and applying a second sinusoidal signal to the surface acoustic wave microfluidic chip according to the delay enable signal to move the target sample thus sorting out the target sample.
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公开(公告)号：US11511277B2
公开(公告)日：2022-11-29
申请号：US16606355
申请日：2017-01-03
Inventor： Hairong Zheng , Wei Zhou , Long Meng , Lili Niu , Zhengrong Lin , Kaiyue Wang , Xiaowei Huang
Abstract: Provided are a microfluidic apparatus, a method and system for introducing a substance into a cell. The microfluidic apparatus includes a cavity channel, a bulk wave generating device and a surface acoustic wave generating device; a microstructure is arranged on an inner wall of the cavity channel, and the microstructure is constructed for forming a bubble by a solution at the microstructure when the solution is injected into the cavity channel; the bulk wave generating device is configured to generate a bulk wave, the bulk wave enables the bubble to resonate for generating a flow field; and the surface acoustic wave generating device is configured to generate a surface acoustic wave and control a position of at least one particle in the solution.
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Patent Agency Ranking
公开(公告)号：US10780437B2
公开(公告)日：2020-09-22
申请号：US15742491
申请日：2015-10-10
Inventor： Hairong Zheng , Fei Li , Feiyan Cai , Long Meng , Chen Wang , Chengxiang Zhang , Weibao Qiu , Yongchuan Li , Fei Yan , Lili Niu , Liufeng Geng , Chaowei Xu
Abstract: Disclosed is a microfluidic system based on an artificially structured acoustic field, comprising a microcavity used to accommodate a solution containing particles and a ultrasonic emission device used to emit ultrasound, and further comprising a phononic crystal plate placed in the microcavity. The phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles. Also disclosed is a method of controlling microfluid particles based on an artificially structured acoustic field. In the particular embodiments, since a microcavity, an ultrasonic emission device and a phononic crystal plate are comprised, the ultrasonic emission device is used to emit ultrasound, and the phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles.
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公开(公告)号：US11707635B2
公开(公告)日：2023-07-25
申请号：US16492405
申请日：2017-04-21
Inventor： Hairong Zheng , Hui Zhou , Lili Niu , Ruibiao Guo , Long Meng , Yongchuan Li , Min Su , Jiqing Huang , Ming Qian
CPC classification number: A61N7/00 , B06B1/0215 , B06B1/067 , A01K29/005 , A61N2007/0026 , B06B2201/76
Abstract: Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.
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公开(公告)号：US11433392B2
公开(公告)日：2022-09-06
申请号：US16903415
申请日：2020-06-17
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Long Meng , Hairong Zheng , Kaiyue Wang , Wei Zhou , Lili Niu , Xiaowei Huang
IPC: B01L3/00
Abstract: A microfluidic chip (100), an apparatus, a system, and a control and preparation method therefor. The method comprises: a substrate (101), and an electrode layer (102) and a functional layer (103) sequentially formed on the substrate (101), said electrode layer (102) comprising a plurality of electrode groups (1021) arranged in an array, the electrode groups (1021) being used for converting electrical signals into acoustic signals when an electrode group is activated, and transmitting the acoustic signals to the functional layer (103); and the functional layer (103) being used for carrying a sample to be tested, and for absorbing the acoustic wave signals emitted by the activated electrode group (1021) and converting same into thermal energy for heating the sample to be tested that is carried at the position corresponding to the activated electrode group (1021).
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公开(公告)号：US10888462B2
公开(公告)日：2021-01-12
申请号：US16474612
申请日：2017-02-08
Inventor： Hairong Zheng , Zhengrong Lin , Lili Niu , Long Meng , Wei Zhou , Xiaowei Huang , Kaiyue Wang
Abstract: Disclosed is an ultrasonic wave generation device for hearing recovery treatment, including an ultrasonic wave generation part. The ultrasonic wave generation part comprises a reference time-delay determination module, an emission sequence parameter determination module and an ultrasonic transducer module. The ultrasonic transducer module is used for emitting actual ultrasonic waves, and the efficiency and precision are improved by focusing by means of a plurality of array elements.
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公开(公告)号：US20200038692A1
公开(公告)日：2020-02-06
申请号：US16492405
申请日：2017-04-21
Inventor： Hairong Zheng , Hui Zhou , Lili Niu , Ruibiao Guo , Long Meng , Yongchuan Li , Min Su , Jiquing Huang , Ming Qian
Abstract: Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.
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