公开(公告)号：US20240293598A1

公开(公告)日：2024-09-05

申请号：US18044655

申请日：2022-11-24

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

Inventor： Yuxiao LAI ,  Yuanchi ZHANG ,  Wei ZHANG

IPC: A61L27/04 ,  A61L27/18

CPC classification number: A61L27/047 ,  A61L27/18 ,  A61L2430/02

Abstract: The present invention provides a shape memory material with a chelating system. The shape memory material with the chelating system comprises polyurethane and a metal complex in a mass ratio of 100: (1-10), and the polyurethane is obtained by reaction of the following components by weight percent: 9.0-10.0% of methylenediphenyl diisocyanate, 0-2.0% of chain extender, 0-3.0% of chelating agent, and 87.0-88.0% of polycaprolactone diol. The present invention provides a novel shape memory material polyurethane-manganese dioxide (SMPU-MnO2) chelating material. Collaboration of its mechanical strength, shape memory performance and Mn2+ responsive release is achieved through the chelating system, and shape recovery is performed by means of the photothermal effect of manganese dioxide under remote control of near-infrared light to achieve self-fixed filling of an irregular bone defect part and responsively release manganese ions, so as to achieve a bone repair biological function.

公开(公告)号：US20230390451A1

公开(公告)日：2023-12-07

申请号：US18044681

申请日：2021-08-11

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

Inventor： Yuxiao LAI ,  Yuanchi ZHANG ,  Wei ZHANG

IPC: A61L24/08 ,  A61L24/02 ,  A61L24/00 ,  A61L24/06 ,  A61L24/10

CPC classification number: A61L24/08 ,  A61L24/02 ,  A61L24/0031 ,  A61L24/06 ,  A61L24/104

Abstract: Provided are a biomedical tape, a preparation method thereof and use thereof. The biomedical tape comprises a hydrogel carrier in dry state and a functional nanomaterial encapsulated within the hydrogel carrier in dry state, and the hydrogel carrier in dry state comprises a thin film body of hyaluronic acid hydrogel and a dopamine-modified polyacrylic acid permeated into a surface of the thin film body of hyaluronic acid hydrogel. The preparation method for the biomedical tape comprises: preparing a hyaluronic acid hydrogel with the functional nanomaterial dispersed therein, and drying and curing the hydrogel to form a film to obtain the thin film body of hyaluronic acid hydrogel; and preparing a dopamine-modified polyacrylic acid solution, and permeating the solution into a surface of the thin film body of hyaluronic acid hydrogel by coating to obtain the biomedical tape.