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公开(公告)号：US20230390451A1
公开(公告)日：2023-12-07
申请号：US18044681
申请日：2021-08-11
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Yuxiao LAI , Yuanchi ZHANG , Wei ZHANG
CPC classification number: A61L24/08 , A61L24/02 , A61L24/0031 , A61L24/06 , A61L24/104
Abstract: Provided are a biomedical tape, a preparation method thereof and use thereof. The biomedical tape comprises a hydrogel carrier in dry state and a functional nanomaterial encapsulated within the hydrogel carrier in dry state, and the hydrogel carrier in dry state comprises a thin film body of hyaluronic acid hydrogel and a dopamine-modified polyacrylic acid permeated into a surface of the thin film body of hyaluronic acid hydrogel. The preparation method for the biomedical tape comprises: preparing a hyaluronic acid hydrogel with the functional nanomaterial dispersed therein, and drying and curing the hydrogel to form a film to obtain the thin film body of hyaluronic acid hydrogel; and preparing a dopamine-modified polyacrylic acid solution, and permeating the solution into a surface of the thin film body of hyaluronic acid hydrogel by coating to obtain the biomedical tape.
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公开(公告)号：US20230330302A1
公开(公告)日：2023-10-19
申请号：US18044684
申请日：2021-07-30
Inventor： Yuxiao LAI , Yuanyi SUN
CPC classification number: A61L27/446 , A61L27/58 , A61L27/56 , A61L27/025 , A61F2/3094 , A61L2430/02 , A61L2400/12 , A61F2002/30985 , A61F2310/00065
Abstract: Provided are an orthopedic repair scaffold, a preparation method thereof and use thereof. The orthopedic repair scaffold is a three-dimensional porous scaffold. A material of the orthopedic repair scaffold comprises the following components in mass percentage: 80%-95% of a biodegradable polymer and 5%-20% of a biodegradable nanoparticle, where the biodegradable nanoparticle is a nanoparticle of manganese compound. The preparation method of the orthopedic repair scaffold comprises: preparing a homogeneous solution comprising a biodegradable polymer and a biodegradable nanoparticle according to the mass percentage; preparing the homogeneous solution through a curing molding process into a molded three-dimensional porous scaffold; and freeze-drying the molded three-dimensional porous scaffold to obtain the orthopedic repair scaffold. The orthopedic repair scaffold can better promote healing of a bone injury and has an excellent mechanical performance and a good medical imaging function.
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公开(公告)号：US20240293598A1
公开(公告)日：2024-09-05
申请号：US18044655
申请日：2022-11-24
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Yuxiao LAI , Yuanchi ZHANG , Wei ZHANG
CPC classification number: A61L27/047 , A61L27/18 , A61L2430/02
Abstract: The present invention provides a shape memory material with a chelating system. The shape memory material with the chelating system comprises polyurethane and a metal complex in a mass ratio of 100: (1-10), and the polyurethane is obtained by reaction of the following components by weight percent: 9.0-10.0% of methylenediphenyl diisocyanate, 0-2.0% of chain extender, 0-3.0% of chelating agent, and 87.0-88.0% of polycaprolactone diol. The present invention provides a novel shape memory material polyurethane-manganese dioxide (SMPU-MnO2) chelating material. Collaboration of its mechanical strength, shape memory performance and Mn2+ responsive release is achieved through the chelating system, and shape recovery is performed by means of the photothermal effect of manganese dioxide under remote control of near-infrared light to achieve self-fixed filling of an irregular bone defect part and responsively release manganese ions, so as to achieve a bone repair biological function.
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公开(公告)号：US20240293310A1
公开(公告)日：2024-09-05
申请号：US18044683
申请日：2021-12-15
Inventor： Yuxiao LAI , Wenjing ZHANG , Wei ZHANG , Cairong LI , Zhenyu YAO
CPC classification number: A61K9/06 , A61K9/0019 , A61K38/44 , A61K47/02 , A61P19/08
Abstract: Disclosed is a metal peroxide composite injectable hydrogel, a preparation method and use thereof. The preparation method comprises the step of dissolving a modified high-molecular polymer, a metal peroxide and a peroxidase in a solvent, mixing evenly, and standing to prepare the hydrogel, wherein the modified high-molecular polymer is a high-molecular polymer grafted with a phenolic hydroxyl group. According to the invention, the metal peroxide induces the modified high-molecular polymer to be quickly crosslinked under an action of the peroxidase to prepare the hydrogel, and the prepared hydrogel has good photo-thermal performance, antibacterial property, tissue adhesion, osteogenesis promoting effect, shape adaptability and injectability, can be well adapted to an irregular bone defect area, and is used for repairing a postoperative defect of tumor through a synergistic effect of multiple functions, which can effectively prevent tumor recurrence and reduce a possibility of implant material infection.
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