公开(公告)号：US3659946A

公开(公告)日：1972-05-02

申请号：US3659946D

申请日：1970-12-09

Applicant: SHIMADZU CORP

Inventor： KOZAWA SCHICHLBEI ,  YAMAMOTO HIDEKI

IPC: G01N15/06 ,  G01N21/51 ,  G01N21/00 ,  G01N21/06 ,  G01N21/26

CPC classification number: G01N21/51 ,  G01N15/065

Abstract: An automated light scattering photometer characterized in that a photoelectric unit used to measure the intensity of light scattered from the sample container at different angles relative to the optical axis of the instrument can be intermittently rotated. This can be achieved by the provision of a pair of switching means, one of which being adapted to be actuated by a pin vertically disposed on the upper surface of a rotary member mounted with said photoelectric unit and the other of which being adapted to be actuated by an actuator means rigidly mounted on a shaft for transmitting the rotational force from a motor to the rotary member. When these switches are closed at the same time, the rotation of the rotary member can be stopped by means of a clutch means. In addition, this photometer of the present invention can be utilized in connection with a commercially available computing machine. To this end, means for integrating the output of the photoelectric unit and that of another photoelectric unit is provided, the output of said integrating means being adapted to be applied to the computing machine.

Abstract translation: 一种自动光散射光度计，其特征在于，可以间歇地旋转用于以相对于仪器的光轴为不同角度测量从样本容器散射的光的强度的光电单元。 这可以通过提供一对开关装置来实现，其中一个开关装置适于由垂直设置在安装有所述光电单元的旋转构件的上表面上的销致动，另一个开关装置适于致动 通过刚性地安装在轴上的致动器装置，用于将旋转力从电动机传递到旋转构件。 当这些开关同时关闭时，旋转构件的旋转可以通过离合器装置停止。 此外，本发明的该光度计可以与市售的计算机结合使用。 为此，提供了用于集成光电单元的输出和另一光电单元的输出的装置，所述积分装置的输出适用于计算机。

公开(公告)号：DE3787706D1

公开(公告)日：1993-11-18

申请号：DE3787706

申请日：1987-11-26

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI

IPC: G01N33/543 ,  G01N33/68 ,  G01N33/546

Abstract: A method for the quantitative determination of antigen (or antibody) which comprises adding a sample containing an antigen (or antibody) to a dispersion of an insoluble carrier of fine particle size with an antibody (or antigen) fixed thereto to effect an antigen-antibody aggentination reaction, measuring absorbance of the reaction mixture, A lambda 1 and A lambda 2, at two different wavelengths, lambda 1 and lambda 2, and calculating the concentration of said antigen (or antibody) in the sample from the absorbance ratio A lambda 1/A lambda 2, which is suitable for the measurement of an antigen or antibody in samples taken from living bodies with simple procedure and high sensitivity.

公开(公告)号：DE3787706T2

公开(公告)日：1994-02-03

申请号：DE3787706

申请日：1987-11-26

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI

IPC: G01N33/543 ,  G01N33/68 ,  G01N33/546

Abstract: A method for the quantitative determination of antigen (or antibody) which comprises adding a sample containing an antigen (or antibody) to a dispersion of an insoluble carrier of fine particle size with an antibody (or antigen) fixed thereto to effect an antigen-antibody aggentination reaction, measuring absorbance of the reaction mixture, A lambda 1 and A lambda 2, at two different wavelengths, lambda 1 and lambda 2, and calculating the concentration of said antigen (or antibody) in the sample from the absorbance ratio A lambda 1/A lambda 2, which is suitable for the measurement of an antigen or antibody in samples taken from living bodies with simple procedure and high sensitivity.

公开(公告)号：JPH10246727A

公开(公告)日：1998-09-14

申请号：JP6231397

申请日：1997-02-28

Applicant: SHIMADZU CORP

Inventor： TANIGAKI TAKAFUMI ,  YAMAMOTO HIDEKI

IPC: G01N1/00 ,  G01N35/10

Abstract: PROBLEM TO BE SOLVED: To estimate an interface position between a plasma layer and a blood cell layer by a simple method. SOLUTION: A specimen dispensing mechanism 2 has a liquid level detecting means for sucking blood specimen filled in a specimen container, centrifugally separated and installed at a predetermined position, dispensing it in a blood analyzer and sensing a liquid level position at its end. A blood cell layer position estimating unit 4 estimates an interface position between a plasma layer and a blood cell layer in the container based on type of the container, the liquid level position sensed by the detecting means and a hematocrit value previously set or measured. A dispensing mechanism controller 6 decides a drop amount of the mechanism 2 based on the interface position estimated by the unit 4 when the specimen of the blood cell layer is sucked in the case of controlling the dispensing by the mechanism 2.

公开(公告)号：JPH0568655B2

公开(公告)日：1993-09-29

申请号：JP1049384

申请日：1984-01-24

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI ,  FURUSAWA KAZUO

IPC: G01N33/536 ,  G01N21/27 ,  G01N33/53 ,  G01N33/543 ,  G01N35/00

公开(公告)号：JPH05240867A

公开(公告)日：1993-09-21

申请号：JP4166992

申请日：1992-02-27

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI

IPC: G01N35/02

Abstract: PURPOSE:To obtain an analyzer, by which anybody can simply pick up cross- contamination data between reagents even if using conditions are changed. CONSTITUTION:An analysis requesting pattern, wherein an analyzing sequence for checking cross-contamination between reagent distributing devices 7 and 10 for a predetermined number of channels and a cell 5 is determined, is stored in a memory part and allocation of channels to respective items is designated. Thus, the cross-contamination between the reagents among all items is measured by repeating this steps.

公开(公告)号：JPH0416746B2

公开(公告)日：1992-03-25

申请号：JP14364782

申请日：1982-08-18

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI

IPC: H01M4/08 ,  G01N35/02 ,  G01N35/10

公开(公告)号：JPH03172762A

公开(公告)日：1991-07-26

申请号：JP31271789

申请日：1989-11-30

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI ,  MATSUMOTO JUNICHI

IPC: G01N35/00

Abstract: PURPOSE:To allow the automatic equal distribution of measuring items to plural measuring units by determining the measurement number of the respective measuring units in such a manner that the measurement number is approximately equaled in accordance with measuring frequencies for the selected measuring items. CONSTITUTION:A measuring item setting section 4 selects the items to measure when the items are selected from an input device 3 and are set in the measuring item setting section 4. The frequencies % of the respective items are then calculated from the frequency coeffts. previously stored for the selected items in a measuring frequency memory section 1 or the measurement number of every item per month inputted in this facility. An equal distributing section 5 distributes the items equally to the set units in such a manner that the measurement number can be balanced between the measuring units in accordance with the frequencies of the selected items from the measuring frequency memory section 1. The measuring sequence within the measuring units of the items equally divided to the respective measuring units is determined in a measuring sequence determining section 6.

公开(公告)号：JPH02223859A

公开(公告)日：1990-09-06

申请号：JP4381889

申请日：1989-02-25

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI ,  MATSUMOTO JUNICHI

IPC: G01N35/00

Abstract: PURPOSE:To exactly determine a desired component by mixing a prescribed reaction reagent with a sample liquid to effect reaction, determining an estimated optical density value at the time of the start of the reaction by the regression equation obtd. by a method of least squares from the plural actually measured optical density values and determining an actually measured optical density value at the time of the end of the reaction. CONSTITUTION:The prescribed reaction reagent is mixed with the sample liquid. The absorbance data is determined from the right after the start of the reaction in an absorbance fluctuating region A and the quadratic regression equation y=at +bt+c is determined by the method of least squares with the measurement groups from alpha to beta thereof. The value of t=0, i.e., y0 at the time of the start of the reaction is determined from this equation. The absorbance ys in the absorbance stationary region B after the end of the reaction is actually measured to determine ys-y0 and the concn. is calculated therefrom.

公开(公告)号：JPH0280961A

公开(公告)日：1990-03-22

申请号：JP23313888

申请日：1988-09-16

Applicant: SHIMADZU CORP

Inventor： YAMAMOTO HIDEKI ,  TSUNASAWA YOSHIO

IPC: G01N35/02

Abstract: PURPOSE:To rapidly and simply stirr a distributed solution after the distribution of a reagent by together providing stirring function to a reagent distribution apparatus. CONSTITUTION:The up-and-down moving means 6 of a reagent distribution and stirring apparatus 1 is driven by a moving mechanism and the nozzle part a2 of a nozzle pipeline (a) falls and the corrugated deformed part (x) of the nozzle part is inserted in the reaction tube 7 at a distribution position. A predetermined amount of a reagent for starting reaction is emitted and distributed in the reaction tube 7 from the nozzle at the leading end of the pipeline (a) by driving a syringe pump 32. Thereafter, the pulse motor 55 of a stirring mechanism 5 is intermittently and repeatedly rotated forwardly and reversely, and the pipeline shaft from the elastic deformable part a1 of the pipeline (a) to the nozzle part thereof is repeatedly revolved through gears 54, 53 while supported in a twisted state at the deformable part a1 in a forward and reverse direction. With this operation, the deformed part (x) is revolved in the reaction tube 7 to stirr and mix a specimen and the reagent.