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1.发明申请AGENT FOR SEDATING RESPONSE TO EXTERNAL STIMULATION IN SKIN AND METHOD FOR SEDATING THAT RESPONSE TECHNICAL FIELD 审中-公开用于对皮肤外部刺激作出反应的试剂和用于评估反应技术领域的方法
公开(公告)号：WO2015136718A1
公开(公告)日：2015-09-17
申请号：PCT/JP2014/057629
申请日：2014-03-12
Applicant: SHISEIDO COMPANY, LTD.
Inventor： HOSOI, Junichi , INOUE, Kaori , YAMADA, Shoko , SATO, Minako
IPC: A61K31/716 , A61K31/77 , A61K36/73 , A61P17/00
CPC classification number: A61K31/716 , A61K31/77 , A61K36/738 , A61K2300/00
Abstract: An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof, polyoxyethylene (POE)/polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.
Abstract translation: 本发明的目的是提供一种用于镇静皮肤对外部刺激的反应的药剂。 上述目的是通过在朗格汉斯细胞中发现促进CD39基因表达的成分来实现的。 更具体地说，本发明是基于羧甲基-β葡聚糖或其盐，聚氧乙烯（POE）/聚氧丙烯（POP）无规共聚物二甲醚和rosewater的组合促进CD39基因表达的发现。
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2.发明授权AGENT FOR SEDATING RESPONSE TO EXTERNAL STIMULATION IN SKIN AND METHOD FOR SEDATING THAT RESPONSE TECHNICAL FIELD 有权MEANS镇静应对外部刺激对镇静这种反应在皮肤和方法
公开(公告)号：EP2941254B1
公开(公告)日：2017-01-11
申请号：EP14715531.1
申请日：2014-03-12
Applicant: Shiseido Company, Ltd.
Inventor： HOSOI, Junichi , INOUE, Kaori , YAMADA, Shoko , SATO, Minako
IPC: A61K31/716 , A61K31/77 , A61K36/738 , A61P17/00
CPC classification number: A61K31/716 , A61K31/77 , A61K36/738 , A61K2300/00
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3.发明公开AGENT FOR SEDATING RESPONSE TO EXTERNAL STIMULATION IN SKIN AND METHOD FOR SEDATING THAT RESPONSE TECHNICAL FIELD 有权MEANS镇静应对外部刺激对镇静这种反应在皮肤和方法
公开(公告)号：EP2941254A1
公开(公告)日：2015-11-11
申请号：EP14715531.1
申请日：2014-03-12
Applicant: Shiseido Company Ltd.
Inventor： HOSOI, Junichi , INOUE, Kaori , YAMADA, Shoko , SATO, Minako
IPC: A61K31/716 , A61K31/77 , A61K36/73 , A61P17/00
CPC classification number: A61K31/716 , A61K31/77 , A61K36/738 , A61K2300/00
Abstract: An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof, polyoxyethylene (POE)/polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.
Abstract translation: 本发明的一个目的是提供一种用于皮肤镇静的对外界刺激的响应提供的试剂。 上述目的什么通过找到一个部件取得确实促进在朗格汉斯细胞CD39的基因表达。 更具体地，本发明是基于这样的发现所做羧甲基β葡聚糖或其聚氧乙烯（POE）/聚氧化丙烯（POP）无规共聚物二甲醚和玫瑰水促进CD39基因表达的盐的组合。
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