公开(公告)号：WO2015136718A1

公开(公告)日：2015-09-17

申请号：PCT/JP2014/057629

申请日：2014-03-12

Applicant: SHISEIDO COMPANY, LTD.

Inventor： HOSOI, Junichi ,  INOUE, Kaori ,  YAMADA, Shoko ,  SATO, Minako

IPC: A61K31/716 ,  A61K31/77 ,  A61K36/73 ,  A61P17/00

CPC classification number: A61K31/716 ,  A61K31/77 ,  A61K36/738 ,  A61K2300/00

Abstract: An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof, polyoxyethylene (POE)/polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.

Abstract translation: 本发明的目的是提供一种用于镇静皮肤对外部刺激的反应的药剂。 上述目的是通过在朗格汉斯细胞中发现促进CD39基因表达的成分来实现的。 更具体地说，本发明是基于羧甲基-β葡聚糖或其盐，聚氧乙烯（POE）/聚氧丙烯（POP）无规共聚物二甲醚和rosewater的组合促进CD39基因表达的发现。

公开(公告)号：EP2941254B1

公开(公告)日：2017-01-11

申请号：EP14715531.1

申请日：2014-03-12

Applicant: Shiseido Company, Ltd.

Inventor： HOSOI, Junichi ,  INOUE, Kaori ,  YAMADA, Shoko ,  SATO, Minako

IPC: A61K31/716 ,  A61K31/77 ,  A61K36/738 ,  A61P17/00

CPC classification number: A61K31/716 ,  A61K31/77 ,  A61K36/738 ,  A61K2300/00

公开(公告)号：EP2941254A1

公开(公告)日：2015-11-11

申请号：EP14715531.1

申请日：2014-03-12

Applicant: Shiseido Company Ltd.

Inventor： HOSOI, Junichi ,  INOUE, Kaori ,  YAMADA, Shoko ,  SATO, Minako

IPC: A61K31/716 ,  A61K31/77 ,  A61K36/73 ,  A61P17/00

CPC classification number: A61K31/716 ,  A61K31/77 ,  A61K36/738 ,  A61K2300/00

Abstract: An object of the present invention is to provide an agent for sedating the response of skin to external stimulation. The aforementioned object was achieved by finding a component that promotes CD39 gene expression in Langerhans cells. More specifically, the present invention is based on the finding that the combination of carboxymethyl-beta glucan or a salt thereof, polyoxyethylene (POE)/polyoxypropylene (POP) random copolymer dimethyl ether and rosewater promotes CD39 gene expression.

Abstract translation: 本发明的一个目的是提供一种用于皮肤镇静的对外界刺激的响应提供的试剂。 上述目的什么通过找到一个部件取得确实促进在朗格汉斯细胞CD39的基因表达。 更具体地，本发明是基于这样的发现所做羧甲基β葡聚糖或其聚氧乙烯（POE）/聚氧化丙烯（POP）无规共聚物二甲醚和玫瑰水促进CD39基因表达的盐的组合。

公开(公告)号：EP2520273B1

公开(公告)日：2019-03-20

申请号：EP10840992.1

申请日：2010-12-27

Applicant: Shiseido Company, Ltd.

Inventor： SATO, Minako ,  TESHIGAWARA, Takashi ,  WATANABE, Kei

IPC: A61K8/34 ,  A61K8/36 ,  A61K8/55 ,  A61K8/60 ,  A61K8/86 ,  A61Q19/00

公开(公告)号：EP2520273A1

公开(公告)日：2012-11-07

申请号：EP10840992.1

申请日：2010-12-27

Applicant: Shiseido Company, Ltd.

Inventor： SATO, Minako ,  TESHIGAWARA, Takashi ,  WATANABE, Kei

IPC: A61K8/34 ,  A61K8/36 ,  A61K8/55 ,  A61K8/60 ,  A61K8/86 ,  A61Q19/00

CPC classification number: A61K8/553 ,  A61K8/342 ,  A61K8/345 ,  A61K8/361 ,  A61K2800/262 ,  A61Q19/00

Abstract: Problem To provide a transparent to translucent cosmetic composition which is highly stable, and can impart excellent actual feelings of effectiveness in use, such as a feeling of skin penetration, a feeling of non-stickiness, and a skin-softening effect after application thereof to the skin.
Means for Resolution A transparent to translucent cosmetic composition comprising: (a) a hydrogenated phospholipid, (b) one or more selected from among branched higher fatty acids and higher alcohols, and (c) a polyalcohol that acts as a good solvent and/or a poor solvent for component (a). Preferably, component (b) is isostearic acid and/or isostearyl alcohol. Preferably, the ratio of component (a)/component (b) is from 1/0.01 to 1/0.4 (by mass).

Abstract translation: 课题提供透明性高的透明化妆品组合物，该化妆品组合物在涂抹后具有皮肤渗透感，无粘感，皮肤软化效果等优异的使用效果， 皮。 用于分辨率的手段透明的半透明化妆品组合物，其包含：（a）氢化磷脂，（b）选自支化高级脂肪酸和高级醇中的一种或多种，​​和（c）充当良溶剂的多元醇和/或 组分（a）的不良溶剂。 优选地，组分（b）是异硬脂酸和/或异硬脂醇。 组分（a）/组分（b）的比例优选为1 / 0.01-1 / 0.4（按质量计）。