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    LYSIS DEVICES HAVING A PIEZO ELEMENT AND METHODS
    2.
    发明申请
    LYSIS DEVICES HAVING A PIEZO ELEMENT AND METHODS 审中-公开

    公开(公告)号：WO2022031459A1

    公开(公告)日：2022-02-10

    申请号：PCT/US2021/042953

    申请日：2021-07-23

    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

    Inventor： JASPERSE, Jeffrey R. ,  PAULICKA, Peter ,  BENSON, Paul

    IPC: B01L3/00 ,  G01N33/543

    Abstract: A lysis device including a sample vessel, at least one piezo element, and a controller is disclosed. The sample vessel has a microchannel formed therein. The sample vessel has at least one port extending through a surface to the microchannel. The piezo element is attached to the surface of the sample vessel. The controller has logic to cause the controller to emit a first signal including a series of frequencies to the at least one piezo element to cause the at least one piezo element to generate ultrasonic acoustic standing waves in the sample vessel, to receive a second signal indicative of measured vibration signals from the sample vessel detected by the at least one piezo element, and to determine a resonant frequency of the sample vessel using the measured vibration signals.

    ABSORBANCE SPECTROSCOPY ANALYZER AND METHOD OF USE
    3.
    发明申请
    ABSORBANCE SPECTROSCOPY ANALYZER AND METHOD OF USE 审中-公开

    公开(公告)号：WO2022031458A1

    公开(公告)日：2022-02-10

    申请号：PCT/US2021/042945

    申请日：2021-07-23

    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

    Inventor： JASPERSE, Jeffrey R.

    IPC: G01J3/427 ,  G01J3/02 ,  G01J3/10 ,  G01J3/12 ,  G01J3/28

    Abstract: Absorbance spectroscopy methods and systems are disclosed including a spectroscopy analyzer, comprising: an optical element device positioned to receive an analysis light that passes through a sample of a fluid specimen from an illumination unit, the analysis light including first light in a first light range and second light in a second light range different than the first light range, the optical element device comprising: a housing assembly that defines an internal space; and a dichroic mirror-reflector within the internal space positioned to receive the analysis light, the dichroic mirror-reflector configured to filter the analysis light such that a first portion of the analysis light in the first light range is reflected off the dichroic mirror-reflector as a spectrometer light, and such that a second portion of the analysis light in the second light range passes through the dichroic mirror-reflector as a detector light.

    METHOD AND ANALYZER TO CORRECT FOR UNKNOWN INTERFERENCES IN A PATIENT BLOOD SAMPLE
    4.
    发明申请
    METHOD AND ANALYZER TO CORRECT FOR UNKNOWN INTERFERENCES IN A PATIENT BLOOD SAMPLE 审中-公开

    公开(公告)号：WO2021252564A1

    公开(公告)日：2021-12-16

    申请号：PCT/US2021/036515

    申请日：2021-06-09

    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

    Inventor： JASPERSE, Jeffrey R.

    IPC: A61B5/1455 ,  A61B5/145 ,  G01J3/02 ,  G01N21/27 ,  G01N33/49 ,  G01N1/4077 ,  G01N2001/4094 ,  G01N21/31

    Abstract: Analyzers and methods of use are disclosed, including a blood analyzer comprising a light source to transmit an optical signal; a detector to generate data indicative of optical signal intensity; a transparent sample vessel between the light source and the detector; a dispensing device to pass a first portion of the blood sample comprising whole blood or lysed blood into the vessel at a first instance of time, and to pass a plasma portion of the blood sample into the vessel at a second instance of time; a controller to cause a processor to obtain first and second data generated by the detector, the first data indicative of the optical signal passing through the first portion of the blood sample and the second data indicative of the optical signal passing through the plasma, to determine a total absorbance spectrum in which the first data is adjusted by the second data.

    DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC DETECTION PAD
    5.
    发明申请
    DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC DETECTION PAD 审中-公开
    使用色谱检测垫检测HEMOLYSIS

    公开(公告)号：WO2015191450A1

    公开(公告)日：2015-12-17

    申请号：PCT/US2015/034672

    申请日：2015-06-08

    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

    Inventor： LEDDEN, David J. ,  COX, Janine A. ,  JASPERSE, Jeffrey R.

    IPC: G01N33/72

    CPC classification number: G01N33/725 ,  G01N33/558 ,  G01N33/721 ,  G01N33/726

    Abstract: In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. The chromatographic detection pad defines a path for capillary fluid flow. The chromatographic detection pad has a pore size. The sample application site on the chromatographic detection pad is for application of a portion of the whole blood sample. The detection site on the chromatographic detection pad is spaced apart from the application site and is downstream of the sample application site. The chromatographic detection pad is devoid of a compound located downstream of the application site that is reactive to the whole blood sample.

    Abstract translation: 在一个方面，本文公开的发明概念涉及用于检测全血样品中游离血红蛋白的存在的色谱测定装置。 该装置包括具有样品应用位点和检测侧的色谱检测垫。 色谱检测垫定义毛细管流体流动路径。 色谱检测垫具有孔径。 色谱检测垫上的样品应用位点是用于全血样品的一部分的应用。 色谱检测垫上的检测位置与应用场所间隔开，位于样品应用场所的下游。 色谱检测垫没有位于应用位点下游的化合物，其对全血样品具有反应性。

    DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC DETECTION PAD
    9.
    发明公开
    DETECTION OF HEMOLYSIS USING A CHROMATOGRAPHIC DETECTION PAD 审中-公开
    NACHWEIS VONHÄMOLYSEMITHILEL EINES CHROMATOGRAPHISCHEN NACHWEISPADS

    公开(公告)号：EP3155430A1

    公开(公告)日：2017-04-19

    申请号：EP15807510.1

    申请日：2015-06-08

    Applicant: Siemens Healthcare Diagnostics Inc.

    Inventor： LEDDEN, David J. ,  COX, Janine A. ,  JASPERSE, Jeffrey R.

    IPC: G01N33/558 ,  G01N33/72

    CPC classification number: G01N33/725 ,  G01N33/558 ,  G01N33/721 ,  G01N33/726

    Abstract: In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. The chromatographic detection pad defines a path for capillary fluid flow. The chromatographic detection pad has a pore size. The sample application site on the chromatographic detection pad is for application of a portion of the whole blood sample. The detection site on the chromatographic detection pad is spaced apart from the application site and is downstream of the sample application site. The chromatographic detection pad is devoid of a compound located downstream of the application site that is reactive to the whole blood sample.

    Abstract translation: 在一个方面，本文公开的发明概念涉及用于检测全血样品中游离血红蛋白的存在的色谱测定装置。 该装置包括具有样品施加位点和检测侧的色谱检测垫。 色谱检测垫定义了毛细管流体流动的路径。 色谱检测垫具有孔径。 色谱检测垫上的样品应用位点是用于全血样品的一部分的应用。 色谱检测垫上的检测位置与应用场所间隔开，位于样品应用场所的下游。 色谱检测垫没有位于应用位点下游的化合物，其对全血样品具有反应性。

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