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公开(公告)号：WO2015191450A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/034672
申请日：2015-06-08
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： LEDDEN, David J. , COX, Janine A. , JASPERSE, Jeffrey R.
IPC: G01N33/72
CPC classification number: G01N33/725 , G01N33/558 , G01N33/721 , G01N33/726
Abstract: In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. The chromatographic detection pad defines a path for capillary fluid flow. The chromatographic detection pad has a pore size. The sample application site on the chromatographic detection pad is for application of a portion of the whole blood sample. The detection site on the chromatographic detection pad is spaced apart from the application site and is downstream of the sample application site. The chromatographic detection pad is devoid of a compound located downstream of the application site that is reactive to the whole blood sample.
Abstract translation: 在一个方面，本文公开的发明概念涉及用于检测全血样品中游离血红蛋白的存在的色谱测定装置。 该装置包括具有样品应用位点和检测侧的色谱检测垫。 色谱检测垫定义毛细管流体流动路径。 色谱检测垫具有孔径。 色谱检测垫上的样品应用位点是用于全血样品的一部分的应用。 色谱检测垫上的检测位置与应用场所间隔开，位于样品应用场所的下游。 色谱检测垫没有位于应用位点下游的化合物，其对全血样品具有反应性。
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公开(公告)号：WO2015157669A1
公开(公告)日：2015-10-15
申请号：PCT/US2015/025367
申请日：2015-04-10
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： LEDDEN, David J.
CPC classification number: G01N33/723 , B01L3/502753 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/087 , G01N33/52
Abstract: Kits, microfluidics devices, and assays for use in methods of spectroscopically determining a ratio of glycated hemoglobin to total hemoglobin in a whole blood sample are disclosed.
Abstract translation: 公开了用于光谱测定全血样品中糖化血红蛋白与总血红蛋白的比例的方法的试剂盒，微流体装置和测定法。
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公开(公告)号：WO2015191853A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035326
申请日：2015-06-11
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： LEDDEN, David J. , COX, Janine A.
CPC classification number: B01L3/502 , A61B5/150022 , A61B5/150343 , B01L3/0293 , B01L3/5027 , B01L2200/12 , B01L2300/0838 , B01L2300/12 , B01L2400/0406 , B01L2400/0475 , B01L2400/0677 , B01L2400/0683 , G01N1/28 , G01N1/38
Abstract: Inventive concepts disclosed herein are directed to a capillary tube and a force assisted sample ejection mechanism. The capillary tube may be at least one of dissolvable or breakable. The force assisted sample ejecting mechanism releasing at least part of the sample of the first liquid from the capillary tube by at least one of abruptly shaking the capillary tube at least once or breaking the capillary tube.
Abstract translation: 本文公开的发明概念涉及毛细管和力辅助样品排出机构。 毛细管可以是可溶解或易碎的至少一种。 力辅助样品排出机构通过使毛细管突然摇动至少一次或破坏毛细管的至少一种，从毛细管释放第一液体的至少一部分样品。
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4.发明申请LUMINESCENT OXYGEN CHANNELING IMMUNOASSAY UTILIZING THREE ANTIBODIES AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开使用三种抗体的荧光氧自由基免疫测定及其生产和使用方法
公开(公告)号：WO2015148479A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/022209
申请日：2015-03-24
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： LI, Jay J. , LEDDEN, David J. , COWDEN, Eric Scott , LU, Donglai
IPC: G01N21/76
CPC classification number: G01N33/5308 , G01N21/76 , G01N33/542 , G01N33/54306 , G01N33/54366 , G01N33/582 , G01N2800/32 , G01N2800/325
Abstract: A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. The first, second, and third antibodies or binding fragments thereof may be provided in any form that allows these antibodies/binding fragments to function in accordance with the presently disclosed and claimed inventive concept(s). For example, each of the first, second, and third antibodies/binding fragments may be a polyclonal antibody/binding fragment or a monoclonal antibody/binding fragment.
Abstract translation: 公开了一种化学发光检测系统，以及包含其的试剂盒和微流体装置。 还公开了使用该系统，套件和装置的方法。 第一，第二和第三抗体或其结合片段可以以允许这些抗体/结合片段根据本发明公开和要求保护的发明构思起作用的任何形式提供。 例如，第一，第二和第三抗体/结合片段中的每一个可以是多克隆抗体/结合片段或单克隆抗体/结合片段。
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公开(公告)号：WO2014152322A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027208
申请日：2014-03-14
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： LEDDEN, David J.
CPC classification number: G01N21/76 , B01L3/5027 , F21K2/06 , G01N33/582
Abstract: A chemiluminescent detection system, kits and microfluidics devices containing same, and methods of use thereof, are disclosed.
Abstract translation: 公开了一种化学发光检测系统，包含其的试剂盒和微流体装置及其使用方法。
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Patent Agency Ranking6.发明申请LUMINESCENT OXYGEN CHANNELING IMMUNOASSAYS UTILIZING ELECTROCHEMICAL DISCHARGE OF SINGLET OXYGEN AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开利用氧化黄铜的电化学放电免疫荧光免疫荧光及其生产方法及其应用
公开(公告)号：WO2014152165A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027025
申请日：2014-03-14
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： LEDDEN, David J.
CPC classification number: G01N27/3275 , G01N33/542 , G01N33/5438
Abstract: Chemiluminescent detection systems, kits, and microfluidics devices containing same, as well as methods of production and use thereof, are disclosed.
Abstract translation: 公开了含有其的化学发光检测系统，试剂盒和微流体装置，以及其生产和使用方法。
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公开(公告)号：EP3505067B1
公开(公告)日：2020-07-29
申请号：EP18196227.5
申请日：2015-06-11
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： LEDDEN, David J. , COX, Janine A.
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8.发明公开LUMINESCENT OXYGEN CHANNELING IMMUNOASSAYS UTILIZING ELECTROCHEMICAL DISCHARGE OF SINGLET OXYGEN AND METHODS OF PRODUCTION AND USE THEREOF 有权发光氧渠化免疫ASSAYS进行生产及其用途单线态氧和方法电化学放电
公开(公告)号：EP2970852A1
公开(公告)日：2016-01-20
申请号：EP14768580.4
申请日：2014-03-14
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： LEDDEN, David J.
CPC classification number: G01N27/3275 , G01N33/542 , G01N33/5438
Abstract: Chemiluminescent detection systems, kits, and microfluidics devices containing same, as well as methods of production and use thereof, are disclosed.
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公开(公告)号：EP2972245B1
公开(公告)日：2020-07-15
申请号：EP14768031.8
申请日：2014-03-14
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： LEDDEN, David J.
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公开(公告)号：EP3154429A1
公开(公告)日：2017-04-19
申请号：EP15805748.9
申请日：2015-06-11
Applicant: Siemens Healthcare Diagnostics Inc.
Inventor： LEDDEN, David J. , COX, Janine A.
CPC classification number: B01L3/502 , A61B5/150022 , A61B5/150343 , B01L3/0293 , B01L3/5027 , B01L2200/12 , B01L2300/0838 , B01L2300/12 , B01L2400/0406 , B01L2400/0475 , B01L2400/0677 , B01L2400/0683 , G01N1/28 , G01N1/38
Abstract: Inventive concepts disclosed herein are directed to a capillary tube and a force assisted sample ejection mechanism. The capillary tube may be at least one of dissolvable or breakable. The force assisted sample ejecting mechanism releasing at least part of the sample of the first liquid from the capillary tube by at least one of abruptly shaking the capillary tube at least once or breaking the capillary tube.
Abstract translation: 本文公开的发明概念涉及毛细管和力辅助样品排出机构。 毛细管可以是可溶解的或易碎的至少一种。 力辅助样品排出机构通过使毛细管突然颤动至少一次或破坏毛细管的至少一种，从毛细管释放第一液体的至少一部分样品。
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