公开(公告)号：AU2008267274A1

公开(公告)日：2008-12-31

申请号：AU2008267274

申请日：2008-06-23

Applicant: SOLVAY PHARM BV

Inventor： TURSKI LECHOSLAW A ,  KRUSE CORNELIS G ,  TULP MARTINUS ,  VADER SANDER ,  STOIT AXEL

IPC: C07D487/04 ,  A61K31/519 ,  A61P11/00 ,  A61P15/10

公开(公告)号：AU2008267273A1

公开(公告)日：2008-12-31

申请号：AU2008267273

申请日：2008-06-23

Applicant: SOLVAY PHARM BV

Inventor： VADER SANDER ,  TULP MARTINUS ,  KRUSE CORNELIS G ,  STOIT AXEL ,  TURSKI LECHOSLAW A

IPC: C07C291/04 ,  A61K31/135 ,  A61P25/24

公开(公告)号：AU2006218012A1

公开(公告)日：2006-08-31

申请号：AU2006218012

申请日：2006-02-17

Applicant: SOLVAY PHARM BV

Inventor： CHOLLET MARYLENE ,  FEENSTRA ROELOF W ,  DRUKARCH BENJAMIN ,  TULP MARTINUS ,  BAKKER WOUTER I IWEMA ,  VLIET BERNARD J VAN ,  SCHOFFELMEER ANTON N M ,  CHRISTEN MARIE-ODILE ,  BURGOT JEAN-LOUISE

IPC: C07D339/04 ,  A61K31/385

Abstract: The invention relates to dithiolethiones derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment, amelioration or prevention of conditions associated with dysfunction of monoamine neurotransmission. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：AU2005313388A1

公开(公告)日：2006-06-15

申请号：AU2005313388

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： HES ROELOF VAN ,  TULP MARTINUS ,  KRUSE CORNELIS G ,  SMID PIETER

IPC: A61K31/496 ,  A61P25/00 ,  C07D405/12

Abstract: The present invention relates to a group of novel 3 -(2-piperidin-4-yl-ethyl)-1H-indole derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine-D 2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.