公开(公告)号：WO9958500B1

公开(公告)日：1999-12-29

申请号：PCT/DE9901417

申请日：1999-05-10

Applicant: SOLVAY PHARM GMBH ,  REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10

CPC classification number: C07D291/04 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  Y02P20/55

Abstract: The invention relates to a method for stereochemically controlled production of azacyclic compounds of general formula (I), whereby the substituents have the meaning cited in the description. The invention also relates to intermediate products of this method and to novel azacyclenes.

Abstract translation: 描述了立体化学控制制备通式（I）的氮杂环化合物的方法，其中取代基具有本说明书中给出的含义和该方法的中间体以及新的氮杂环。

公开(公告)号：AU2004232495B2

公开(公告)日：2010-04-22

申请号：AU2004232495

申请日：2004-04-21

Applicant: SOLVAY PHARM GMBH

Inventor： ZORGDRAGER JAN ,  FINNER EMIL ,  HEINRICH TIMO ,  PAHL AXEL ,  VERVEER PIETER C ,  LUITJENS BERND-MARTIN

IPC: C07D487/04 ,  A61K31/519 ,  A61P9/12

Abstract: The present invention relates to the novel compound 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo[2,3d]pyrimidine hydrogen mesylate, the polymorphic alpha and beta forms thereof, and a method for the production of said compounds.

公开(公告)号：ES2290696T3

公开(公告)日：2008-02-16

申请号：ES04728571

申请日：2004-04-21

Applicant: SOLVAY PHARM GMBH

Inventor： HEINRICH TIMO ,  PAHL AXEL ,  LUITJENS BERND-MARTIN ,  FINNER EMIL ,  VERVEER PIETER C ,  ZORGDRAGER JAN

IPC: C07D487/04 ,  A61K31/519 ,  A61P9/12

Abstract: Hidrógeno-mesilato de 4-(4-trans-hidroxi-ciclohexil)amino-2-fenil-7H-pirrolo[2, 3-d]pirimidina.

公开(公告)号：CA2522810A1

公开(公告)日：2004-11-04

申请号：CA2522810

申请日：2004-04-21

Applicant: SOLVAY PHARM GMBH

Inventor： PAHL AXEL ,  LUITJENS BERND-MARTIN ,  HEINRICH TIMO ,  VERVEER PIETER C ,  FINNER EMIL ,  ZORGDRAGER JAN

IPC: A61K31/519 ,  A61P9/12 ,  C07D487/04

Abstract: The present invention relates to the novel compound 4- (4-trans- hydroxycyclohexyl)amino-2-phenyl-7H~-pyrrolo[2,3d]pyrimidine hydrogen mesylate, the polymorphic .alpha. and .beta. forms thereof and a method for the production of said compounds.

公开(公告)号：AU2004232495A1

公开(公告)日：2004-11-04

申请号：AU2004232495

申请日：2004-04-21

Applicant: SOLVAY PHARM GMBH

Inventor： ZORGDRAGER JAN ,  FINNER EMIL ,  HEINRICH TIMO ,  PAHL AXEL ,  VERVEER PIETER C ,  LUITJENS BERND-MARTIN

IPC: A61K31/519 ,  A61P9/12 ,  C07D487/04

Abstract: The present invention relates to the novel compound 4-(4-trans-hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo[2,3d]pyrimidine hydrogen mesylate, the polymorphic alpha and beta forms thereof, and a method for the production of said compounds.

公开(公告)号：DE59910141D1

公开(公告)日：2004-09-09

申请号：DE59910141

申请日：1999-05-10

Applicant: SOLVAY PHARM GMBH

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10

Abstract: A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate products of this method and to novel azacyclenes.

公开(公告)号：AT272621T

公开(公告)日：2004-08-15

申请号：AT99934470

申请日：1999-05-10

Applicant: SOLVAY PHARM GMBH

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10

Abstract: A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate products of this method and to novel azacyclenes.

公开(公告)号：AU2003232842A1

公开(公告)日：2003-12-22

申请号：AU2003232842

申请日：2003-05-30

Applicant: SOLVAY PHARM GMBH

Inventor： WEBER DIRK ,  KESSLER HORST ,  BERGER CLAUDIA ,  ANTEL JOCHEN ,  HEINRICH TIMO

IPC: A61K31/4045 ,  A61K31/4439 ,  A61K38/00 ,  A61P1/14 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/02 ,  C07D209/20 ,  C07D401/12 ,  C07D405/12 ,  C07K5/06 ,  C07K5/065 ,  C07K5/087 ,  A61K31/405 ,  A61K38/05 ,  A61K38/06 ,  C07K5/062 ,  C07K5/072 ,  C07K5/078

公开(公告)号：NZ508043A

公开(公告)日：2003-05-30

申请号：NZ50804399

申请日：1999-05-10

Applicant: SOLVAY PHARM GMBH

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10 ,  C07D211/46

Abstract: A process for stereochemically controlled production of azacyclic compounds of formula (I), whereby the substituents have the meaning as described in the specification, the intermediate products of this process and the resultant azacyclenes are disclosed.

公开(公告)号：ZA200006337B

公开(公告)日：2001-05-16

申请号：ZA200006337

申请日：2000-11-06

Applicant: SOLVAY PHARM GMBH

Inventor： REGGELIN MICHAEL ,  HEINRICH TIMO ,  JUNKER BERND ,  ANTEL JOCHEN ,  PREUSCHOFF ULF

IPC: C07D219/06 ,  C07C381/10 ,  C07D207/12 ,  C07D209/52 ,  C07D221/16 ,  C07D221/22 ,  C07D291/04 ,  C07F7/10 ,  C07D ,  C07C ,  C07F

Abstract: A method for stereochemically controlled production of azacyclic compounds of general formula (I) in which the substituents have the meanings given in the specification. The invention also relates to intermediate products of this method and to novel azacyclenes.