公开(公告)号：AT310732T

公开(公告)日：2005-12-15

申请号：AT98115651

申请日：1998-08-20

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：TR9801681A2

公开(公告)日：1999-03-22

申请号：TR9801681

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHIRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  C07D ,  A61K

CPC classification number: C07D243/08 ,  Y02P20/55

公开(公告)号：HU9801888A2

公开(公告)日：1999-05-28

申请号：HU9801888

申请日：1998-08-17

Applicant: SOLVAY PHARM GMBH

Inventor： ANTEL JOCHEN ,  BIELENBERG GERHARD-WILHELM ,  BRUECKNER REINHARD ,  DAVID SAMUEL ,  EECKHOUT CHRISTIAN ,  PECK MICHAEL ,  ZIEGLER DIETER

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：CZ9802672A3

公开(公告)日：1999-03-17

申请号：CZ267298

申请日：1998-08-21

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

CPC classification number: C07D243/08 ,  Y02P20/55

公开(公告)号：CZ267298A3

公开(公告)日：1999-03-17

申请号：CZ267298

申请日：1998-08-21

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：CA2245926A1

公开(公告)日：1999-02-27

申请号：CA2245926

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： PECK MICHAEL ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  ZIEGLER DIETER ,  DAVID SAMUEL ,  BRUECKNER REINHARD ,  ANTEL JOCHEN

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  C07D405/00

Abstract: Neurokinin-antagonistic compounds corresponding to formula I: in which R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R3 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R2 and R3 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R4 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and R5 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R4 and R5 together are alkylenedioxy with 1 to 2 carbon atoms, bonded to adjacent carbon atoms of the phenyl ring, R6 is lower alkyl, halogen or trifluoromethyl, R7 is lower alkyl, halogen or trifluoromethyl, A is a -(CH2) n- group in which n represents an integer from 1 to 3, or an -NH-(CH2) m - group in which m represents an integer from 2 to 3, and B is an alkylene chain with 1 to 3 carbon atoms optionally substituted by lower alkyl, and physiologically acceptable salts thereof and processes for the preparation of these compounds.

公开(公告)号：DE59813212D1

公开(公告)日：2005-12-29

申请号：DE59813212

申请日：1998-08-20

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：NZ331523A

公开(公告)日：2000-02-28

申请号：NZ33152398

申请日：1998-08-24

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  A61K31/395 ,  C07D223/18 ,  C07D223/20

Abstract: 7-phenyl-1,4-diazepane derivatives of the formula 1 R1 is H or lower alkyl R2 is H, lower alkyl, lower alkoxy, halogen or CF3 R3 is H, lower alkyl, lower alkoxy, halogen or CF3 R2 and R3 together are alkylenedioxy with 1-2-carbon atoms, bonded to adjacent carbon atoms of the phenyl ring R4 is H, lower alkyl, lower alkoxy, halogen or CF3 R5 is lower alkyl, H, lower alkoxy, halogen or CF3 R4 and R5 together are alkylenedioxy with 1-2-carbon atoms, bonded to adjacent carbon atoms of the phenyl ring R6 is lower alkyl, halogen, or CF3 R7 is lower alkyl, halogen or CF3 A is a -(CH2)n- group where n = 1-3 or -NH-(CH2)m- where m is 2 -3 B is an alkylene chain with 1-3-carbon atoms optionally substituted by lower alkyl Or a physiologically compatible acid addition salt thereof. Also claimed is a process for preparation of these compounds for treating prophylaxis of a pathological condition induced by neurokinin.

公开(公告)号：BR9803250A

公开(公告)日：2000-02-08

申请号：BR9803250

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：AU8190098A

公开(公告)日：1999-03-11

申请号：AU8190098

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  ZIEGELER DIETER ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).