公开(公告)号：WO2005039639A3

公开(公告)日：2005-08-11

申请号：PCT/EP2004052468

申请日：2004-10-07

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG GERHARD-WILHELM ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  A61P9/14

CPC classification number: A61K45/06 ,  A61K31/4178 ,  A61K31/506 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions comprising selective imidazoline receptor agonists combined with angiotensin II receptor blockers. In particular, the present invention relates to pharmaceutical compositions comprising Moxonidine and Eprosartan mesylate. The invention also relates to the use of said compositions in the manufacture of a medicament for the treatment of hypertension, especially in hypertensive patients already suffering from type II diabetes or being susceptible to developing type II diabetes.

Abstract translation: 本发明涉及包含与血管紧张素II受体阻断剂组合的选择性咪唑啉受体激动剂的药物组合物。 特别地，本发明涉及包含莫索尼定和甲磺酸依普罗沙坦的药物组合物。 本发明还涉及所述组合物在制备用于治疗高血压的药物中的用途，特别是在已经患有II型糖尿病或易于发展为II型糖尿病的高血压患者中。

公开(公告)号：WO2005039639B1

公开(公告)日：2005-09-22

申请号：PCT/EP2004052468

申请日：2004-10-07

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG GERHARD-WILHELM ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  A61P9/14

CPC classification number: A61K45/06 ,  A61K31/4178 ,  A61K31/506 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions comprising selective imidazoline receptor agonists combined with angiotensin II receptor blockers. In particular, the present invention relates to pharmaceutical compositions comprising Moxonidine and Eprosartan mesylate. The invention also relates to the use of said compositions in the manufacture of a medicament for the treatment of hypertension, especially in hypertensive patients already suffering from type II diabetes or being susceptible to developing type II diabetes.

Abstract translation: 本发明涉及包含与血管紧张素II受体阻滞剂组合的选择性咪唑啉受体激动剂的药物组合物。 具体而言，本发明涉及包含莫索尼定和甲磺酸普罗沙坦的药物组合物。 本发明还涉及所述组合物在制备用于治疗高血压的药物中的用途，所述药物尤其是已经患有II型糖尿病或易患II型糖尿病的高血压患者。

公开(公告)号：PL193724B1

公开(公告)日：2007-03-30

申请号：PL32822198

申请日：1998-08-26

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00

公开(公告)号：AT310732T

公开(公告)日：2005-12-15

申请号：AT98115651

申请日：1998-08-20

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08

Abstract: 1-Benzoyl-4-aminoacyl-7-phenyl-1,4-diazepine derivatives (I) are new. Also new are four classes of intermediates. 1,4-Diazepine derivatives of formula (I) and their acid addition salts are new. Ph1 = phenyl substituted by R2 and R3; Ph2 = phenyl substituted by R4 and R5; Ph3 = 3-(R6)-5-(R7)-phenyl; R1 = H or alkyl; R2-R5 = H, alkyl, alkoxy, halo or CF3; or R2+R3 or R4+R5 on adjacent C = 1-2C alkylenedioxy; R6,R7 = alkyl, halo or CF3; A = (CH2)n or NH(CH2)m; n = 1-3; m = 2 or 3; and B = 1-3C alkylene chain (optionally substituted by alkyl).

公开(公告)号：NZ331524A

公开(公告)日：2000-02-28

申请号：NZ33152498

申请日：1998-08-24

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  A61K31/445

Abstract: Urea derivatives of the formula 1 are distinguished by properties antagonistic to neurokinin receptors with an action profile beneficial for the treatment of functional and inflammatory disorders of the gastrointestinal tract of large animals where R1 is H or lower alkyl R2 is H or halogen R3 is H or lower alkoxy and a physiologically compatible acid addition salt thereof. Also claimed is a pharmaceutical composition comprising the above formula, process for making and use for treating a pathological condition in which a neurokinin is involved as transfer agent.

公开(公告)号：TR9801681A2

公开(公告)日：1999-03-22

申请号：TR9801681

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUECKNER REINHARD ,  ZIEGLER DIETER ,  EECKHOUT CHIRISTIAN ,  BIELENBERG GERHARD-WILHELM ,  PECK MICHAEL

IPC: A61K31/55 ,  A61P1/00 ,  A61P43/00 ,  C07D243/08 ,  C07D ,  A61K

CPC classification number: C07D243/08 ,  Y02P20/55

公开(公告)号：ID20787A

公开(公告)日：1999-03-04

申请号：ID981171

申请日：1998-08-27

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  F23R3/40

Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.

公开(公告)号：ZA986721B

公开(公告)日：1999-02-02

申请号：ZA986721

申请日：1998-07-28

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  C07D ,  A61K

Abstract: Compounds of Formula I wherein R1 is hydrogen or lower alkyl, R2 is hydrogen or halogen and R3 is hydrogen or lower alkoxy, and their pharmacologically acceptable acid addition salts and pharmaceutical compositions containing these compounds and also processes for the preparation of these compounds. Pharmaceutical composition containing these compounds are suitable, for example, for treating functional and inflammatory disorders of the gastrointestinal tract.

公开(公告)号：ZA9806721B

公开(公告)日：1999-02-02

申请号：ZA9806721

申请日：1998-07-28

Applicant: SOLVAY PHARM GMBH

Inventor： JASSERAND DANIEL ,  DAVID SAMUEL ,  ANTEL JOCHEN ,  BRUCKNER REINHARD ,  EECKHOUT CHRISTIAN ,  BIELENBERG GERHARD-WILHELM

IPC: C07D403/06 ,  A61K31/495 ,  A61K31/496 ,  A61P1/00 ,  A61P29/00 ,  A61P43/00 ,  C07D209/00 ,  C07D209/14 ,  C07D241/00 ,  C07D ,  A61K

CPC classification number: C07D209/14 ,  Y02P20/55

公开(公告)号：ES2304624T3

公开(公告)日：2008-10-16

申请号：ES04766880

申请日：2004-10-07

Applicant: SOLVAY PHARM GMBH

Inventor： BAUM DOMINIQUE ,  BIELENBERG GERHARD-WILHELM ,  BOEDECKER BERND ,  THORMAEHLEN DIRK

IPC: A61K45/06 ,  A61K31/4172 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/506 ,  A61P9/14

Abstract: Una composición farmacéutica que comprende Moxonidina o una de sus sales farmacéuticamente aceptables en calidad de un agonista selectivo del receptor de imidazolina I1 y Eprosartán o una de sus sales farmacéuticamente aceptables en calidad de un bloqueante del receptor de angiotensina II y un excipiente farmacéuticamente aceptable.