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1.发明申请LIQUID PHARMACEUTICAL FORMULATIONS CONTAINING 3,7-DIAZABICYCLO`3,3,1! NONANES FOR TREATING ANTI-ARRHYTHMIC EVENTS 审中-公开含有3,7-DIAZABICYCLO的液体药物制剂3,3,1！ 治疗抗精神活动的非必需品
公开(公告)号：WO2004045591A3
公开(公告)日：2004-07-22
申请号：PCT/EP0312844
申请日：2003-11-17
Applicant: SOLVAY PHARM GMBH
Inventor： STRAUB MATTHIAS , JANSEN JOHANNES WILHELMUS CATH , DE VRIES MICHIEL HENRICUS , STEINBORN CLAUS RUDOLF , CAUTREELS WERNER
IPC: A61K31/439 , A61K31/4747 , A61P9/06
CPC classification number: A61K31/439 , A61K31/4747
Abstract: The present invention relates to the use of 3,7-diazabicyclo[3,3,1]nonane compounds, preferably of 9,9-alkylene-3,7diazabicyclo[3,3,1]nonane compounds, and most preferably to the use of tedisamil, and the physiologically acceptable acid addition salts and/or solvates thereof, in the form of a liquid pharmaceutical preparation for the treatment and/or prophylaxis of anti-arrhythmic events in human patients, preferably in conversion of recent onset of atrial fibrillation (Afib) or flutter to normal sinus rhythm (NSR) in human patients. Furthermore, the invention relates to method of treatments and to pharmaceutical products.
Abstract translation: 本发明涉及3,7-二氮杂双环[3,3,1]壬烷化合物，优选9,9-亚烷基-3,7-二氮杂双环[3,3,1]壬烷化合物的用途，最优选 以用于治疗和/或预防人类患者抗心律失常事件的液体药物制剂的形式使用泰迪沙米及其生理上可接受的酸加成盐和/或溶剂合物，优选地转化近来发生的心房颤动 （Afib）或扑动至正常窦性心律（NSR）。 此外，本发明涉及治疗方法和药物产品。
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公开(公告)号：DE602006013792D1
公开(公告)日：2010-06-02
申请号：DE602006013792
申请日：2006-02-17
Applicant: SOLVAY PHARM GMBH
Inventor： WITTE KLAUS , ZIEGLER DIETER , STRAUB MATTHIAS , FISCHER YVAN
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公开(公告)号：UA85546C2
公开(公告)日：2009-02-10
申请号：UA2005005967
申请日：2003-11-17
Applicant: SOLVAY PHARM GMBH
Inventor： STRAUB MATTHIAS , JANSEN JOHANNES WILHELMUS CATH , DE VRIES MICHIEL HENRICUS , STEINBORN CLAUS RUDOLF , CAUTREELS WERNER
IPC: A61K31/439 , A61K31/4747 , A61P9/06
Abstract: Данноеизобретениеотноситсяк применениюпроизводных 3,7-диазабицикло[3.3.1]нонана, преимущественнопроизводных 9,9-алкилен-3,7-диазабицикло[3.3.1]нонанаи предпочтительнее - применениятедисамилаи егофизиологическиприемлемыхкислотно-аддитивныхсолейи/илисольватовв формежидкогофармацевтическогопрепаратадлялеченияи/илипрофилактикиаритмическихприступову человека, преимущественноприконверсииначальнойфибрилляциипредсердий (Afib) илитрепетанияв нормальныйсинусовыйритм (NSR) упациентов. Крометого, изобретениеотноситсяк способулеченияи фармацевтическимпрепаратам.
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公开(公告)号：AU2003296580B2
公开(公告)日：2010-02-18
申请号：AU2003296580
申请日：2003-11-17
Applicant: SOLVAY PHARM GMBH
Inventor： VRIES MICHIEL HENRICUS DE , STRAUB MATTHIAS , CAUTREELS WERNER , JANSEN JOHANNES WILHELMUS CATHARINE MARIA , STEINBORN CLAUS RUDOLF
IPC: A61K31/439 , A61K31/4747 , A61P9/06
Abstract: The present invention relates to the use of 3,7-diazabicyclo[3,3,1]nonane compounds, preferably of 9,9-alkylene-3,7-diazabicyclo[3,3,1]nonane compounds, and most preferably to the use of tedisamil, and the physiologically acceptable acid addition salts and/or solvates thereof, in the form of a liquid pharmaceutical preparation for the treatment and/or inhibition of anti-arrhythmic events in human patients, preferably in conversion of recent onset of atrial fibrillation or flutter to normal sinus rhythm in humans. Furthermore, the invention concerns related methods of treatment and pharmaceutical products.
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公开(公告)号：BRPI0512379A
公开(公告)日：2008-03-11
申请号：BRPI0512379
申请日：2005-06-22
Applicant: SOLVAY PHARM GMBH
Inventor： ZIEGLER DIETER , WITTE KLAUS , STRAUB MATTHIAS , FISCHER YVAN , THORMAEHLEN DIRK , HOELTJE DAGMAR
IPC: A61K31/00 , A61K31/4178 , A61K31/4184 , A61K31/55 , A61K45/06 , A61P9/00 , A61P9/12
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Patent Agency Ranking
公开(公告)号：MX2007009977A
公开(公告)日：2007-09-26
申请号：MX2007009977
申请日：2006-02-17
Applicant: SOLVAY PHARM GMBH
Inventor： STRAUB MATTHIAS , ZIEGLER DIETER , WITTE KLAUS , FISCHER YVAN
Abstract: Se describe una nueva politerapia para enfermedades o dolencias cardiovasculares, administrando una combinacion sinergica de por lo menos un inhibidor de endopeptidasa neutra, por lo menos un inhibidor del sistema productor de endotelina endogena y por lo menos un diuretico, preferentemente un diuretico de tiazida o un antagonista del receptor A1 de adenosina.
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公开(公告)号：AR049921A1
公开(公告)日：2006-09-13
申请号：ARP050102502
申请日：2005-06-17
Applicant: SOLVAY PHARM GMBH
Inventor： ZIEGLER DIETER , WITTE KLAUS , STRAUB MATTHIAS , FISCHER YVAN , THORMAHLEN DIRK , HOLTJE DAGMAR
IPC: A61K31/4178 , A61K9/10 , A61K9/20 , A61K9/28 , A61K31/4184 , A61K31/55 , A61K31/553 , A61K45/06 , A61P9/00 , A61P9/12
Abstract: Una nueva terapia de combinacion se describe para enfermedades cardiovasculares, en particular hipertension esencial, hipertension pulmonar y/o insuficiencia cardíaca congestiva, administrando una combinacion sinérgica de, al menos un inhibidor de endopeptidasa neutra, al menos un inhibidor del sistema productor de endotelina endogena y, al menos un antagonista el receptor AT1. Kit que comprende dicha terapia.
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公开(公告)号：CA2596922A1
公开(公告)日：2006-08-24
申请号：CA2596922
申请日：2006-02-17
Applicant: SOLVAY PHARM GMBH
Inventor： ZIEGLER DIETER , WITTE KLAUS , FISCHER YVAN , STRAUB MATTHIAS
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公开(公告)号：AU2005315608A1
公开(公告)日：2006-06-22
申请号：AU2005315608
申请日：2005-12-14
Applicant: SOLVAY PHARM GMBH
Inventor： KOOPMAN PAULUS ANTONIUS REMIGI , ZIEGLER DIETER , WITTE KLAUS , STRAUB MATTHIAS
IPC: A61K31/55 , A61K31/366 , A61K31/40 , A61K45/06 , A61P9/10
Abstract: A combination therapy is disclosed for treating or inhibiting cardiovascular or metabolic diseases or conditions through a combination of at least one inhibitor of neutral endopeptidase (=NEP), at least one inhibitor of the endogenous endothelin producing system and at least one HMG CoA reductase inhibitor. Pharmaceutical compositions are also described comprising NEP inhibitors, inhibitors of the endogenous endothelin producing system and HMG CoA reductase inhibitors and the use of these pharmaceutical composition in the prophylaxis or treatment of cardiovascular and/or metabolic disorders or diseases in mammals (including humans).
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公开(公告)号：AU2006215583B2
公开(公告)日：2011-05-12
申请号：AU2006215583
申请日：2006-02-17
Applicant: SOLVAY PHARM GMBH
Inventor： ZIEGLER DIETER , WITTE KLAUS , FISCHER YVAN , STRAUB MATTHIAS
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