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    Medicament for treating hypertension.
    8.
    发明专利
    Medicament for treating hypertension. 未知

    公开(公告)号：ZA200105828B

    公开(公告)日：2002-07-15

    申请号：ZA200105828

    申请日：2001-07-16

    Applicant: SOLVAY PHARM GMBH

    Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

    IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  A61K ,  A61P

    Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

    9.
    发明专利
    未知

    公开(公告)号：NO20020132D0

    公开(公告)日：2002-01-11

    申请号：NO20020132

    申请日：2002-01-11

    Applicant: SOLVAY PHARM GMBH

    Inventor： ROZSA SUSANNA ,  PAPP JULIUS GY ,  THORMAEHLEN DIRK ,  WALDECK HARALD

    IPC: A61K31/55 ,  C07D223/16 ,  A61K31/704 ,  A61K45/00 ,  A61K45/06 ,  A61P9/00 ,  A61P21/00 ,  A61P35/00 ,  A61P37/04 ,  A61P39/02 ,  A61P39/06 ,  A61K

    Abstract: The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical, and of their salts and biolabile esters, for the prophylaxis and/or treatment of heart damage caused by cardiotoxic doses of medicaments or chemicals, in larger mammals and in particular humans. The invention is particularly applicable to the prophylaxis and/or treatment of heart damage, in particular to the myocardium, which may occur during cytostatic chemotherapy. The invention also includes the use of the afore-mentioned benzazepin-N-acetic acid derivatives for adjuvant treatment in therapies in which medicaments having oxidative-toxic side-effects are used, and the preparation of medicaments suitable for this prophylaxis and/or treatment or adjuvant treatment.

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