公开(公告)号：HK1096105A1

公开(公告)日：2007-05-25

申请号：HK07103455

申请日：2007-03-30

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  FISCHER YVAN ,  ZIEGLER DIETER ,  WESKE MICHAEL ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  MESSINGER JOSEF ,  PAHL AXEL ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI ,  TURSKI LECHOSLAW

IPC: A61K20090101 ,  A61K38/00 ,  A61P20090101 ,  A61P9/12 ,  C07K20090101 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：NO20061821A

公开(公告)日：2006-06-22

申请号：NO20061821

申请日：2006-04-25

Applicant: SOLVAY PHARM GMBH

Inventor： TURSKI LECHOSLAW ,  ZIEGLER DIETER ,  MESSINGER JOSEF ,  WESKE MICHAEL ,  PAHL AXEL ,  HOELTJE DAGMAR ,  FISCHER YVAN ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

CPC classification number: C07K5/06139 ,  A61K38/00 ,  C07K5/0222 ,  Y02A50/409

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：CA2539895A1

公开(公告)日：2005-04-07

申请号：CA2539895

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： FISCHER YVAN ,  MICHAELIS KATHRIN ,  TURSKI LECHOSLAW ,  IKONOMIDOU HRISSANTHI ,  HOELTJE DAGMAR ,  PAHL AXEL ,  MESSINGER JOSEF ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  WESKE MICHAEL ,  ZIEGLER DIETER

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：AU2004276002B2

公开(公告)日：2010-07-22

申请号：AU2004276002

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  ZIEGLER DIETER ,  MICHAELIS KATHRIN ,  PAHL AXEL ,  MESSINGER JOSEF ,  WESKE MICHAEL ,  TURSKI LECHOSLAW ,  HOEFER CONSTANZE ,  FISCHER YVAN ,  KARIMI-NEJAD YASMIN ,  IKONOMIDOU HRISSANTHI

IPC: C07K5/02 ,  A61K38/00 ,  A61P9/12 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：UA85195C2

公开(公告)日：2009-01-12

申请号：UAA200604364

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  FISCHER YVAN ,  CYGLER DITER ,  WESKE MICHAEL ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  MESSINGER JOSEF ,  PAHL AXEL ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI ,  TURSKI LECHOSLAW

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

Abstract: Взаявкеописаныновыесоединения, которыепроявляютингибирующеевлияниенанейтральнуюэндопептидазу (НЭП) и/илирастворимуюэндопептидазучеловека (лРЭП), общейформулыІ EMBED ISISServer , Ів которойзаместители R1, R2, R3 и R4 имеютзначения, указанныев описании, атакжелекарственныесредства, которыесодержатэтисоединения, вчастностилекарственныесредства, пригодныедлялеченияилипредупреждениясердечно-сосудистыхзаболеваний, половойдисфункциии/илипатологическихсостояний, связанныхс апоптозом.

公开(公告)号：BRPI0414744A

公开(公告)日：2006-11-21

申请号：BRPI0414744

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  FISCHER YVAN ,  ZIEGLER DIETER ,  WESKE MICHAEL ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  MESSINGER JOSEF ,  PAHL AXEL ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI ,  TURSKI LECHOSLAW

IPC: A61K38/00 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078 ,  C07K5/06 ,  A61K38/05

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：AU2004276002A1

公开(公告)日：2005-04-07

申请号：AU2004276002

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： HOELTJE DAGMAR ,  ZIEGLER DIETER ,  MICHAELIS KATHRIN ,  PAHL AXEL ,  MESSINGER JOSEF ,  WESKE MICHAEL ,  TURSKI LECHOSLAW ,  HOEFER CONSTANZE ,  FISCHER YVAN ,  KARIMI-NEJAD YASMIN ,  IKONOMIDOU HRISSANTHI

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：NO20061821L

公开(公告)日：2006-06-22

申请号：NO20061821

申请日：2006-04-25

Applicant: SOLVAY PHARM GMBH

Inventor： TURSKI LECHOSLAW ,  ZIEGLER DIETER ,  MESSINGER JOSEF ,  WESKE MICHAEL ,  PAHL AXEL ,  HOELTJE DAGMAR ,  FISCHER YVAN ,  MICHAELIS KATHRIN ,  KARIMI-NEJAD YASMIN ,  HOEFER CONSTANZE ,  IKONOMIDOU HRISSANTHI

IPC: C07K5/06 ,  A61K38/00 ,  A61K38/05 ,  A61P9/12 ,  C07K5/02 ,  C07K5/078

Abstract: Described are novel compounds with neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity of the general formula (I), wherein the substituents R , R , R and R have the meanings given in the description and also medicaments containing these compounds, in particular medicaments suitable for treating or preventing cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.

公开(公告)号：MXPA06003226A

公开(公告)日：2006-05-22

申请号：MXPA06003226

申请日：2004-09-23

Applicant: SOLVAY PHARM GMBH

Inventor： TURSKI LECHOSLAW

IPC: A61K38/05 ,  A61K38/00 ,  A61P9/12 ,  C07K5/02 ,  C07K5/06 ,  C07K5/078

Abstract: Se describen compuestos nuevos con actividad inhibidora de la endopeptidasa neutra (NEP) y/o la endopeptidasa humana soluble (hSEP) de la formula general I, (ver formula I) en donde los sustituyentes R1, R2, R3 y R4 tienen los significados dados en la descripcion, asi como medicamentos que contienen estos compuestos, en particular medicamentos adecuados para tratamiento o prevencion de enfermedades cardiovasculares, disfuncion sexual y/o condiciones adversas asociadas con apoptosis.