公开(公告)号：DK1154777T3

公开(公告)日：2005-06-06

申请号：DK00903681

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAEHLEN DIRK ,  WALDECK HARALD ,  WILKINS MARTIN R

IPC: A61K31/55 ,  A61P9/12

公开(公告)号：CZ20012672A3

公开(公告)日：2002-02-13

申请号：CZ20012672

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：NO20013958A

公开(公告)日：2001-10-15

申请号：NO20013958

申请日：2001-08-15

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12 ,  A61D9/12

CPC classification number: A61K31/55

公开(公告)号：CA2362273A1

公开(公告)日：2000-08-24

申请号：CA2362273

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAHLEN DIRK ,  WALDECK HARALD ,  WILKINS MARTIN R

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The invention relates to the use of benzazepine-N ethanoic acid derivatives, containing an oxo group bonded to the nitrogen atom in the .alpha.-position and which are substituted by a 1-(carboxy alkyl)-cyclopentyl-carbonyl amino radical in position 3. It also relates to the use of the salts and unstable esters of these derivatives in the treatment of hypertension, particularly t o the treatment of certain types of secondary hypertension in large mammals an d humans and to the production of suitable medicaments for this treatment. The origins of the hypertension which should be treated can vary greatly. The invention relates specifically to those types of secondary hypertension whic h may arise as a result of various non-cardiac diseases.

公开(公告)号：DE19906310A1

公开(公告)日：2000-08-17

申请号：DE19906310

申请日：1999-02-16

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: 3-(1-(2-Aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido)-2,3,4,5-tet rahydro-2-oxo-1H-benz(b)azepine-1-acetic acid derivatives (I) are used to prepare pharmaceutical compositions for treating hypertension in large mammals and humans. 3-(1-(2-Aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido)-2,3,4,5-tet rahydro-2-oxo-1H-benz(b)azepine-1-acetic acid derivatives of formula (I) or their salts are used to prepare pharmaceutical compositions for treating hypertension in large mammals and humans. R = phenyl- or naphthyl-substituted lower alkyl, where phenyl is optionally substituted by lower alkyl, lower alkoxy or halogen; R , R = H or biolabile ester groups.

公开(公告)号：SK287254B6

公开(公告)日：2010-04-07

申请号：SK10822001

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAHLEN DIRK ,  WALDECK HARALD

IPC: A61K31/00 ,  C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: It is described the use of benzazepine-N ethanoic acid derivatives, containing an oxo group bonded to the nitrogen atom in the alpha -position and which are substituted by a 1-(carboxy alkyl)-cyclopentyl-carbonyl amino radical in position 3, and of the salts and unstable esters of these derivatives, in the production of pharmaceutical preparation for the treatment of hypertension, particularly to the treatment of certain types of secondary hypertension in large mammals and humans.

公开(公告)号：PL350167A1

公开(公告)日：2002-11-18

申请号：PL35016700

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：BR0008260A

公开(公告)日：2001-11-06

申请号：BR0008260

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAEHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：NZ514058A

公开(公告)日：2001-09-28

申请号：NZ51405800

申请日：2000-02-10

Applicant: SOLVAY PHARM GMBH

Inventor： WILKINS MARTIN R ,  THORMAHLEN DIRK ,  WALDECK HARALD

IPC: C07D223/16 ,  A61K31/55 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.

公开(公告)号：NO329588B1

公开(公告)日：2010-11-15

申请号：NO20013958

申请日：2001-08-15

Applicant: SOLVAY PHARM GMBH

Inventor： THORMAHLEN DIRK ,  WALDECK HARALD ,  WILKINS MARTIN R

IPC: A61K31/55 ,  C07D223/16 ,  A61P9/00 ,  A61P9/12

Abstract: The present invention relates to the use of benzazepine-N-acetic acid derivatives which contain an oxo-group in the alpha-position to the nitrogen atom and are substituted in position 3 by a 1-(carboxyalkyl)cyclo-entylcarbonylamino radical, and their salts and biolabile esters for the treatment of hypertension, particularly for the treatment of certain forms of secondary hypertension, in larger mammals and particularly humans, and for the production of pharmaceutical compositions suitable for this treatment. The cause of the hypertension to be treated may have a wide variety of origins. The invention particularly relates to the treatment of those forms of secondary hypertension which may occur as a result of various non-cardiac diseases.