公开(公告)号：US20030180791A1

公开(公告)日：2003-09-25

申请号：US10443982

申请日：2003-05-23

Applicant: ST. LOUIS UNIVERSITY

Inventor： Govindaswamy Chinnadurai

IPC: C12Q001/68 ,  G01N033/574 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/47

CPC classification number: C07K16/18 ,  C07K14/4747 ,  C07K2319/00

Abstract: A domain of Bcl-2 that suppresses apoptosis by allowing cell survival permits cell proliferation when mutated. The wild type domain includes amino acid residues 51 to 97 (SEQ ID NO:13) of Bcl-2. Peptides including the domain and nucleotides encoding the domain are useful in molecular screening of human tumors for the presence of mutations that allow proliferation of cells that were otherwise marked for apoptosis. The peptides are also useful to screen for proteins that play a role in the modulation of cellular proliferation.

Abstract translation: 通过允许细胞存活来抑制细胞凋亡的Bcl-2的结构域在突变时允许细胞增殖。 野生型结构域包括Bcl-2的氨基酸残基51至97（SEQ ID NO：13）。 包括结构域和编码该结构域的核苷酸的肽可用于人肿瘤的分子筛选，用于存在允许另外标记为细胞凋亡的细胞增殖的突变。 肽也可用于筛选在细胞增殖调节中起作用的蛋白质。