公开(公告)号：US10517528B2

公开(公告)日：2019-12-31

申请号：US15105613

申请日：2014-12-18

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois

IPC: A61B5/00 ,  A61B5/0488 ,  A61B5/0452 ,  A61M16/00 ,  A61B5/113 ,  A61B5/08

Abstract: The present disclosure relates to a method and a system for validating inspiratory muscle activity of a patient. Left and right electrical activity signals respectively representing activity of a left muscle and of a right muscle synchronized with an inspiratory effort of the patient are acquired from non-invasive sensors. A cardiac activity signal is extracted from the left and right electrical activity signals. A synchrony, a symmetry or a proportionality of the left and right electrical activity signals from which the cardiac activity signal is extracted is verified. A mechanical ventilation system incorporating the system for validating inspiratory muscle activity of the patient is also disclosed.

公开(公告)号：US10960162B2

公开(公告)日：2021-03-30

申请号：US16067220

申请日：2016-12-29

Applicant: St. Michael's Hospital

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois

IPC: A61M16/00 ,  A61B5/091 ,  A61B5/08 ,  A61B5/0488 ,  A61B5/00

Abstract: A device and method for controlling a level of ventilatory assist applied to a patient by a mechanical ventilator measures, during patient's assisted breath, an inspiratory volume Vassist produced by both the patient and the mechanical ventilator, an inspiratory volume Vvent contributed by the mechanical ventilator, and an inspiratory assist pressure Pvent produced by the mechanical ventilator. A first relation between pressure Pvent and volume Vassist and a second relation between pressure Pvent and volume Vvent are calculated. Using the first and second relations, a ratio is determined between pressure Pvent at volume Vvent and pressure Pvent at volume Vassist, with volume Vvent equal to volume Vassist, for a plurality of volumes Vvent and Vassist. Values of Pvent are multiplied by the corresponding calculated ratios to calculate a third relation between a predicted inspiratory pressure Ppred and volume Vassist. The mechanical ventilator is responsive to the third relation to control the level of ventilatory assist.

公开(公告)号：US10758693B2

公开(公告)日：2020-09-01

申请号：US15261532

申请日：2016-09-09

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois ,  Fredrik Jalde

IPC: A61M16/20 ,  A61M16/00

Abstract: The present disclosure relates to a method and a mechanical ventilation system for adjusting a level of ventilatory assist to a patient. A neuro-mechanical efficiency of the patient is determined. A control value is received at the mechanical ventilation system. The level of ventilatory assist to the patient is determined on the basis of the neuro-mechanical efficiency and of the control value. The mechanical ventilation system may be adjusted automatically based on the determined level of ventilatory assist to the patient. Alternatively, the determined level of ventilatory assist to the patient may be displayed for the benefit of an operator and a manual command may be received for adjusting the mechanical ventilation system.

公开(公告)号：US10376663B2

公开(公告)日：2019-08-13

申请号：US14355777

申请日：2012-11-16

Applicant: St. Michael's Hospital

Inventor： Christer Sinderby ,  Norman Comtois ,  Jennifer Beck ,  Pär Emtell ,  Michael Kock

IPC: A61M16/00 ,  A61B5/08 ,  A61B5/0488 ,  A61B5/04 ,  A61B5/00

Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

公开(公告)号：US20190015615A1

公开(公告)日：2019-01-17

申请号：US16067220

申请日：2016-12-29

Applicant: St. Michael's Hospital

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois

IPC: A61M16/00 ,  A61B5/091

Abstract: A device and method for controlling a level of ventilatory assist applied to a patient by a mechanical ventilator measures, during patient's assisted breath, an inspiratory volume Vassist produced by both the patient and the mechanical ventilator, an inspiratory volume Vvent contributed by the mechanical ventilator, and an inspiratory assist pressure Pvent produced by the mechanical ventilator. A first relation between pressure Pvent and volume Vassist and a second relation between pressure Pvent and volume Vvent are calculated. Using the first and second relations, a ratio is determined between pressure Pvent at volume Vvent and pressure Pvent at volume Vassist, with volume Vvent equal to volume Vassist, for a plurality of volumes Vvent and Vassist. Values of Pvent are multiplied by the corresponding calculated ratios to calculate a third relation between a predicted inspiratory pressure Ppred and volume Vassist. The mechanical ventilator is responsive to the third relation to control the level of ventilatory assist.