公开(公告)号：US20160303340A1

公开(公告)日：2016-10-20

申请号：US15193696

申请日：2016-06-27

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer SINDERBY ,  Jennifer BECK ,  Norman COMTOIS

IPC: A61M16/04 ,  A61M16/16 ,  A61M16/20

CPC classification number: A61M16/0486 ,  A61M16/024 ,  A61M16/04 ,  A61M16/08 ,  A61M16/16 ,  A61M16/161 ,  A61M16/20 ,  A61M16/204 ,  A61M16/205 ,  A61M2016/0015 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2202/0208 ,  A61M2230/005 ,  A61M2230/08 ,  A61M2230/202 ,  A61M2230/432

Abstract: A device for providing ventilatory assist to a patient is disclosed. The device comprises a manifold having an inspiratory port to receive an inspiratory flow from an inspiratory supply line, an interface port connectable to an external end of an endotracheal tube inserted in a patient's trachea and an expiratory port configured to receive an expiratory flow from the endotracheal tube via the interface port. An inspiratory lumen has a distal end insertable in the endotracheal tube. A cross-section of the inspiratory lumen is smaller than that of the endotracheal tube to allow gas flowing in the endotracheal tube. The inspiratory flow is directed to the inspiratory lumen, or to the endotracheal tube, or at once to the inspiratory lumen and to the endotracheal tube. A ventilatory assist system and method using the device are also disclosed.

Abstract translation: 公开了一种用于向患者提供通气辅助的装置。 该装置包括具有吸气端口的歧管，以吸收来自吸气供应管线的吸气流，可连接到插入患者气管中的气管插管的外部端口的接口端口和构造成接收来自气管内气管的呼气流量的呼气端口 管通过接口端口。 吸气腔具有可插入气管插管内的远端。 吸气腔的横截面小于气管内管，以允许气体在气管插管中流动。 吸气流量指向吸气管腔或气管插管，或一次到吸气管腔和气管插管。 还公开了使用该装置的通气辅助系统和方法。

公开(公告)号：US10517528B2

公开(公告)日：2019-12-31

申请号：US15105613

申请日：2014-12-18

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois

IPC: A61B5/00 ,  A61B5/0488 ,  A61B5/0452 ,  A61M16/00 ,  A61B5/113 ,  A61B5/08

Abstract: The present disclosure relates to a method and a system for validating inspiratory muscle activity of a patient. Left and right electrical activity signals respectively representing activity of a left muscle and of a right muscle synchronized with an inspiratory effort of the patient are acquired from non-invasive sensors. A cardiac activity signal is extracted from the left and right electrical activity signals. A synchrony, a symmetry or a proportionality of the left and right electrical activity signals from which the cardiac activity signal is extracted is verified. A mechanical ventilation system incorporating the system for validating inspiratory muscle activity of the patient is also disclosed.

公开(公告)号：US20160310069A1

公开(公告)日：2016-10-27

申请号：US15105613

申请日：2014-12-18

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer SINDERBY ,  Jennifer BECK ,  Norman COMTOIS

IPC: A61B5/00 ,  A61M16/00 ,  A61B5/0452 ,  A61B5/113 ,  A61B5/0488

Abstract: The present disclosure relates to a method and a system for validating inspiratory muscle activity of a patient. Left and right electrical activity signals respectively representing activity of a left muscle and of a right muscle synchronized with an inspiratory effort of the patient are acquired from non-invasive sensors. A cardiac activity signal is extracted from the left and right electrical activity signals. A synchrony, a symmetry or a proportionality of the left and right electrical activity signals from which the cardiac activity signal is extracted is verified. A mechanical ventilation system incorporating the system for validating inspiratory muscle activity of the patient is also disclosed.

Abstract translation: 本公开涉及用于验证患者的吸气肌肉活动的方法和系统。 从非侵入性传感器获取分别表示与患者的吸气力同步的左肌肉和右肌肉的活动的左右电活动信号。 从左右电活动信号中提取心脏活动信号。 验证了提取心脏活动信号的左右电活动信号的同步性，对称性或比例​​性。 还公开了结合用于验证患者的吸气肌肉活动的系统的机械通气系统。

公开(公告)号：US10758693B2

公开(公告)日：2020-09-01

申请号：US15261532

申请日：2016-09-09

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois ,  Fredrik Jalde

IPC: A61M16/20 ,  A61M16/00

Abstract: The present disclosure relates to a method and a mechanical ventilation system for adjusting a level of ventilatory assist to a patient. A neuro-mechanical efficiency of the patient is determined. A control value is received at the mechanical ventilation system. The level of ventilatory assist to the patient is determined on the basis of the neuro-mechanical efficiency and of the control value. The mechanical ventilation system may be adjusted automatically based on the determined level of ventilatory assist to the patient. Alternatively, the determined level of ventilatory assist to the patient may be displayed for the benefit of an operator and a manual command may be received for adjusting the mechanical ventilation system.

公开(公告)号：US10376663B2

公开(公告)日：2019-08-13

申请号：US14355777

申请日：2012-11-16

Applicant: St. Michael's Hospital

Inventor： Christer Sinderby ,  Norman Comtois ,  Jennifer Beck ,  Pär Emtell ,  Michael Kock

IPC: A61M16/00 ,  A61B5/08 ,  A61B5/0488 ,  A61B5/04 ,  A61B5/00

Abstract: The present disclosure relates to a method and a system for quantifying timing discrepancies between inspiratory effort and ventilatory assist. A trigger error is determined by comparing a start time of neural inspiration with a start time of the ventilatory assist. A cycling-off error is determined by comparing an end time of the neural inspiration with an end time of the ventilatory assist. The ventilatory assist is synchronized when the trigger error is lower than a first threshold and the cycling-off error is lower than a second threshold. The ventilatory assist may also be characterized in terms of early or late trigger and of early or late cycling-off. A trigger of a ventilator may be adjusted according to the trigger error and a cycling-off of a ventilator may be adjusted according to the cycling-off error.

公开(公告)号：US20180036006A1

公开(公告)日：2018-02-08

申请号：US15550444

申请日：2016-02-11

Applicant: St. Michael's Hospital

Inventor： João Baptista De Rezende Neto

IPC: A61B17/08

CPC classification number: A61B17/085 ,  A61B2017/081 ,  A61B2017/086

Abstract: A device for management of an open abdomen includes a belt having first and second end portions. The belt is positionable to extend partially around a patient's torso in a taut configuration with the end portions positioned on opposed sides of an incision in the patient's abdomen. A first connector is at the first end portion and a second connector is at the second end portion. The connectors are positionable adjacent each other on the opposed sides of the incision. At least one cinching device is connected to and extends between the connectors. The cinching device is positionable to extend over the incision when the connectors are positioned adjacent each other on opposed sides of the incision. The cinching device is adjustable to cinch the end portions towards each other to hold the incision in an at least partially closed position.

公开(公告)号：US20160220599A1

公开(公告)日：2016-08-04

申请号：US15024406

申请日：2014-09-26

Applicant: ST. MICHAEL'S HOSPITAL ,  THE HOSPITAL FOR SICK CHILDREN

Inventor： Philip A. Marsden ,  Sunit Das ,  Jenny Jing Wang ,  Megan Yijun Wu

IPC: A61K31/7105 ,  A61K45/06 ,  C12N15/113

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  C12N15/11 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  A61K2300/00

Abstract: The present disclosure provides a large intergenic RNA (LIVE) and compositions thereof. Also provided is a nucleic acid molecule that silences the expression of the LIVE. Further provided are methods and uses of the compositions for modulating angiogenesis.

Abstract translation: 本公开提供了大的基因间RNA（LIVE）及其组合物。 还提供了使LIVE的表达沉默的核酸分子。 还提供了用于调节血管发生的组合物的方法和用途。

公开(公告)号：US20190015615A1

公开(公告)日：2019-01-17

申请号：US16067220

申请日：2016-12-29

Applicant: St. Michael's Hospital

Inventor： Christer Sinderby ,  Jennifer Beck ,  Norman Comtois

IPC: A61M16/00 ,  A61B5/091

Abstract: A device and method for controlling a level of ventilatory assist applied to a patient by a mechanical ventilator measures, during patient's assisted breath, an inspiratory volume Vassist produced by both the patient and the mechanical ventilator, an inspiratory volume Vvent contributed by the mechanical ventilator, and an inspiratory assist pressure Pvent produced by the mechanical ventilator. A first relation between pressure Pvent and volume Vassist and a second relation between pressure Pvent and volume Vvent are calculated. Using the first and second relations, a ratio is determined between pressure Pvent at volume Vvent and pressure Pvent at volume Vassist, with volume Vvent equal to volume Vassist, for a plurality of volumes Vvent and Vassist. Values of Pvent are multiplied by the corresponding calculated ratios to calculate a third relation between a predicted inspiratory pressure Ppred and volume Vassist. The mechanical ventilator is responsive to the third relation to control the level of ventilatory assist.

公开(公告)号：US20170128684A1

公开(公告)日：2017-05-11

申请号：US15261532

申请日：2016-09-09

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer SINDERBY ,  Jennifer Beck ,  Norman Comtois ,  Fredrik Jalde

IPC: A61M16/00 ,  A61M16/08 ,  A61M16/20

Abstract: The present disclosure relates to a method and a mechanical ventilation system for adjusting a level of ventilatory assist to a patient. A neuro-mechanical efficiency of the patient is determined. A control value is received at the mechanical ventilation system. The level of ventilatory assist to the patient is determined on the basis of the neuro-mechanical efficiency and of the control value. The mechanical ventilation system may be adjusted automatically based on the determined level of ventilatory assist to the patient. Alternatively, the determined level of ventilatory assist to the patient may be displayed for the benefit of an operator and a manual command may be received for adjusting the mechanical ventilation system.

公开(公告)号：US20160324722A1

公开(公告)日：2016-11-10

申请号：US15108146

申请日：2014-12-23

Applicant: ST. MICHAEL'S HOSPITAL

Inventor： Christer SINDERBY ,  Jennifer BECK ,  Norman COMTOIS

IPC: A61H31/02 ,  A61H9/00

CPC classification number: A61H31/02 ,  A61H9/0057 ,  A61H9/0078 ,  A61H2201/0103 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/1616 ,  A61H2201/163 ,  A61H2201/5005 ,  A61H2201/5071 ,  A61H2230/605 ,  B60K15/03519 ,  B60K15/04 ,  B60K2015/03289 ,  B60K2015/0477 ,  C07C67/03 ,  C07C69/52

Abstract: A negative pressure ventilation device comprises an inflatable tubular enclosure for surrounding a patient's torso and for defining, when inflated, a space between the tubular enclosure and the patient's torso. A sealing arrangement for the space between the tubular enclosure and the patient's torso is configured for positioning between the tubular enclosure and the patient's torso. A port is mounted to the inflatable tubular enclosure for accessing the space between the enclosure and the patient's torso to produce a negative pressure in the space. A method for negative pressure ventilation using the foregoing negative pressure ventilation device and a negative pressure ventilation system comprising the negative pressure ventilation device are also disclosed.

Abstract translation: 负压通气装置包括用于围绕患者躯干的可充气管状外壳，并且用于在膨胀时限定管状外壳和患者躯干之间的空间。 用于管状外壳和患者躯干之间的空间的密封装置被配置用于在管状外壳和患者的躯干之间定位。 端口安装到可充气管状外壳，用于访问外壳和患者躯干之间的空间，以在该空间中产生负压。 还公开了使用上述负压通气装置的负压通气的方法和包括负压通气装置的负压通气系统。