公开(公告)号：WO2004099425A3

公开(公告)日：2005-01-27

申请号：PCT/US2004013495

申请日：2004-05-03

Applicant: STALEY MFG CO A E

Inventor： VAN MARIS ANTONIUS J A ,  PRONK JACOBUS THOMAS ,  VAN DIJKEN JOHANNES PIETER

IPC: C07C51/44 ,  C12N1/14 ,  C12N1/16 ,  C12N1/18 ,  C12N1/19 ,  C12P20060101 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

CPC classification number: C12N1/16 ,  C07C51/44 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

Abstract: Disclosed herein are glucose tolerant C2 carbon source-independent (GCSI) yeast strains having no detectable amount of pyruvate decarboxylase activity, wherein wild type yeast strains for the glucose tolerant C2 carbon source-independent yeast strains are Crabtree positive. Also disclosed are methods of selecting glucose tolerant C2 carbon source-dependent yeast strains, and methods of producing pyruvic acid or salts thereof using glucose tolerant C2 carbon source-independent yeast strain. Further disclosed herein are GCSI yeast strains having a genome that comprises an exogenous lactate dehydrogenase gene.

Abstract translation: 本文公开了不具有可检测量的丙酮酸脱羧酶活性的耐葡萄糖C2碳源（GCSI）酵母菌株，其中用于葡萄糖耐量的C2碳源独立酵母菌株的野生型酵母菌株为Crabtree阳性。 还公开了选择耐受葡萄糖的C2碳源依赖性酵母菌株的方法，以及使用不含葡萄糖的C2碳源独立酵母菌株生产丙酮酸或其盐的方法。 本文进一步公开的是具有包含外源乳酸脱氢酶基因的基因组的GCSI酵母菌株。

公开(公告)号：EP1627052A4

公开(公告)日：2007-07-04

申请号：EP04760664

申请日：2004-05-03

Applicant: STALEY MFG CO A E

Inventor： VAN MARIS ANTONIUS J A ,  PRONK JACOBUS THOMAS ,  VAN DIJKEN JOHANNES PIETER

IPC: C12N1/16 ,  C07C51/44 ,  C12N1/14 ,  C12N1/18 ,  C12N1/19 ,  C12P20060101 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

CPC classification number: C12N1/16 ,  C07C51/44 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

公开(公告)号：CA2524262A1

公开(公告)日：2004-11-18

申请号：CA2524262

申请日：2004-05-03

Applicant: STALEY MFG CO A E

Inventor： VAN DIJKEN JOHANNES PIETER ,  VAN MARIS ANTONIUS J A ,  PRONK JACOBUS THOMAS

IPC: C12N1/14 ,  C07C51/44 ,  C12N1/16 ,  C12N1/18 ,  C12N1/19 ,  C12P20060101 ,  C12P7/40 ,  C12P7/56 ,  C12R1/645

Abstract: Disclosed herein are glucose tolerant C2 carbon source-independent (GCSI) yeast strains having no detectable amount of pyruvate decarboxylase activity , wherein wild type yeast strains for the glucose tolerant C2 carbon source- independent yeast strains are Crabtree positive. Also disclosed are methods of selecting glucose tolerant C2 carbon source-dependent yeast strains, and methods of producing pyruvic acid or salts thereof using glucose tolerant C2 carbon source-independent yeast strain. Further disclosed herein are GCSI yeast strains having a genome that comprises an exogenous lactate dehydrogenase gene.