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    1.
    发明专利
    未知

    公开(公告)号：DE1643535A1

    公开(公告)日：1971-07-01

    申请号：DE1643535

    申请日：1967-07-14

    Applicant: STAMICARBON

    Inventor： ALOYS THOMA JOZEF ,  JAN COONEN JOSEPH ADRIAAN MARI

    IPC: C07C20060101 ,  C07C121/42

    Abstract: 1,162,052. Methionine; #-methylmercapto-α- aminobutyronitrile. STAMICARBON N.V. 3 July, 1967 [14 July, 1966], No. 30625/67. Heading C2C. # - Methylmercapto - α - aminobutyronitrile is prepared by the conversion of # -methyl - mercaptopropionaldehyde in the presence of a cyanide in a liquid medium comprising ammonia, the weight ratio of ammonia to water during the conversion being greater than 1:1, at 0- 60‹ C., preferably 15-40‹ C., under superatmospheric pressures and carrying out the reaction for a period of time to effect a conversion of at least 90 moles per cent of the #-methylmercaptopropionaldehyde. As a source of cyanide hydrogen cyanide or a mixture of sodium cyanide and ammonium chloride may be employed. Methionine is prepared from the #-methylmercapto-α-aminobutyronitrile using the conventional hydrolysis techniques.

    4.
    发明专利
    未知

    公开(公告)号：DE1543907A1

    公开(公告)日：1970-01-02

    申请号：DE1543907

    申请日：1966-06-08

    Applicant: STAMICARBON

    Inventor： HUBERTUS OTTENHEYM JOHANNES ,  ALOYS THOMA JOZEF ,  MARIE-AIMEE GREGOIRE JOHANNES

    IPC: C07C323/52 ,  B01J1/10

    Abstract: The compound 7-amino-4-thia-oenanthic acid, and its nitrile, esters and salts are prepared by reacting beta-mercapto-propionic acid, or its nitrile, esters or salts, with allylamine, the electrons of the nitrogen atom of which are bound, in the presence of a solvent and under the influence of U.V. radiation. The electrons of the nitrogen atom of allylamine may be bound by using the amine in combination with an acid, e.g. HCl or CH3COOH, or by using a molar excess of the beta-mercaptopropionic acid, or by using the amine in the form of a salt. The novel nitrile, esters and salts may be converted to the acid by known methods.

    5.
    发明专利
    未知

    公开(公告)号：DE1518358A1

    公开(公告)日：1969-08-07

    申请号：DE1518358

    申请日：1965-10-01

    Applicant: STAMICARBON

    Inventor： ALOYS THOMA JOZEF ,  MARIE-AIMEE JOHANNES GROGOIRE

    IPC: C01C1/24

    Abstract: Methionine or a salt thereof is recovered from an aqueous solution which additionally contains ammonium sulphate by liquid-liquid extraction with ethanol to yield an aqueous ethanol-rich layer and an ammonium sulphate rich layer, the methionine or salt thereof being recovered from the aqueous ethanol-rich layer, e.g. by crystallization. Extraction is suitably effected above 8 DEG C., preferably 30 DEG C., and employing continuous solvent extraction.

    8.
    发明专利
    未知

    公开(公告)号：DE1518355A1

    公开(公告)日：1969-07-24

    申请号：DE1518355

    申请日：1965-06-29

    Applicant: STAMICARBON

    Inventor： ALOYS THOMA JOZEF ,  WILHELMINUS GIELKENS JOHANNES

    IPC: C07C20060101 ,  C07C149/24

    Abstract: Methionine is prepared by reacting b -methyl-mercaptopropionaldehyde with (a) HCN, (b) NH4CN or (c) an inorganic cyanide, other than NH4CN, mixed with an ammonium salt in an aqueous medium saturated with ammonia at 0-75 DEG C. to form g -methylmercapto-a -aminobutyronitrile and hydrolysing to amine nitrile to methionine. It is preferred to use gaseous, liquid or dissolved HCN and operate at 45-55 DEG C. Ammonia saturation may be maintained by continuously passing gaseous ammonia through the aqueous medium. It is preferred to cool the initial reaction mixture, e.g. to 20 DEG C., to form two layers, an amino-nitrile rich layer and a layer rich in water, return the water rich layer to the aldehyde conversion step and hydrolyse the amino-nitrile rich layer, e.g. using HCl or H2SO4. Examples are provided.

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