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    1.
    发明专利
    未知

    公开(公告)号：DE1157616B

    公开(公告)日：1963-11-21

    申请号：DEST017583

    申请日：1961-03-15

    Applicant: STANDARD OIL CO

    Inventor： COOPERSMITH JOHN MAYER ,  LINSK JACK ,  FIELD EDMUND ,  CARL RALPH WILLIAM ,  MAYERLE EVAN AUBARY

    IPC: C07D215/26 ,  C07D215/28 ,  C07D241/04 ,  C07D263/32 ,  C07D295/067 ,  C07F7/24 ,  C25B3/13

    Abstract: 1,142,337. Nitro amines. MERCK & CO. Inc. 18 May, 1966 [21 May, 1965; 5 May, 1966], No. 22126/66. Heading C2C. [Also in Divisions A5, C4 and D2] The invention comprises nitro amines of the formulµ wherein R 1-3 and R 1 1-3 represent hydrogen or a cycloalkyl, nitro, amino, C 1-8 alkylamino or hydroxy radical or an optionally substituted alkoxy, aryl, heterocyclic or C 1-30 alkyl group, R 4 and R 1 4 are hydrogen or hydroxymethyl groups, Z is a piperazine radical attached through N to the nitroalkane residue or an alkylene diamine radical of the formula -NH(CH 2 ) n NH 2 , and Z 1 is a piperazine radical attached through N atoms to each nitroalkane residue or an alkylene diamine radical -NH(CH 2 ) n NH- where n is 2-8, provided that when Z 1 is a piperazine radical the carbon atoms ortho to the N atoms are unsubstituted, and the acid addition, metal, amine and quaternary ammonium salts thereof. The nitro amines in which R 4 and R 1 4 are hydrogen may be prepared by reacting a nitro-olefin of the formula with amines of the formulµ ZH or Z 1 H 2 , any aromatic amino groups in the nitro-olefin being blocked before the reaction and unblocked after the reaction, followed, if required, by reaction with formaldehyde to obtain the products in which R 4 and R 1 4 are hydroxy-methyl groups. The nitro-olefin reactant is prepared by condensing a carbonyl compound R 1 R 2 CO with a nitroalkane R 3 CH 2 NO 2 , preferably in the presence of an acid aralkaline catalyst, and this condensation may be effected in the presence of the amine ZH or Z 1 H 2 with immediate formation of the nitro amine. The salts of the nitro amines are prepared by conventional methods. Any secondary amino groups may be acylated to yield nitro amides. Numerous examples are provided. The nitro amines possess antimicrobial properties (see Division AS).

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