公开(公告)号：JPH05500499A

公开(公告)日：1993-02-04

申请号：JP51066589

申请日：1989-09-18

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN J MARTIN ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL ,  POLLART DANIEL J

IPC: A61K31/53 ,  A61K31/535 ,  A61K41/00 ,  A61P35/00 ,  C07D20060101 ,  C07D253/08 ,  C07D253/10

公开(公告)号：EP0478545A4

公开(公告)日：1992-08-05

申请号：EP89911346

申请日：1989-09-18

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN J MARTIN ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL ,  POLLART DANIEL J

IPC: A61K31/53 ,  A61K31/535 ,  A61K41/00 ,  A61P35/00 ,  C07D253/08 ,  C07D253/10

CPC classification number: C07D253/10 ,  A61K31/53 ,  A61K31/535

公开(公告)号：HU225965B1

公开(公告)日：2008-01-28

申请号：HU9602225

申请日：1989-09-18

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL ,  BROWN J MARTIN ,  GRANGE EDWARD W

IPC: A61K31/53 ,  A61K31/535 ,  A61K41/00 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D253/08 ,  C07D253/10

公开(公告)号：DK175885B1

公开(公告)日：2005-05-23

申请号：DK223090

申请日：1990-09-17

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN J MARTIN ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL

IPC: C07D253/08 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/00 ,  A61P35/00 ,  C07D253/10

Abstract: A method of using 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents is disclosed. The compounds are shown to specifically radiosensitive hypoxic tumor cells and are additionnally disclosed to be useful as specific cytotoxic agents for these cells.

公开(公告)号：AT170515T

公开(公告)日：1998-09-15

申请号：AT89904704

申请日：1989-03-15

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN J MARTIN ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL

IPC: C07D253/08 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/00 ,  A61P35/00 ,  C07D253/10

Abstract: A method of using 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents is disclosed. The compounds are shown to specifically radiosensitive hypoxic tumor cells and are additionnally disclosed to be useful as specific cytotoxic agents for these cells.

公开(公告)号：PT90039B

公开(公告)日：1994-05-31

申请号：PT9003989

申请日：1989-03-17

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN J MARTIN ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL

IPC: C07D253/08 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/00 ,  A61P35/00 ,  C07D253/10

Abstract: A method of using 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents is disclosed. The compounds are shown to specifically radiosensitive hypoxic tumor cells and are additionnally disclosed to be useful as specific cytotoxic agents for these cells.

公开(公告)号：NO904003L

公开(公告)日：1990-09-13

申请号：NO904003

申请日：1990-09-13

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN MARTIN J ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL

IPC: C07D253/08 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/00 ,  A61P35/00 ,  C07D253/10

Abstract: A method of using 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents is disclosed. The compounds are shown to specifically radiosensitive hypoxic tumor cells and are additionnally disclosed to be useful as specific cytotoxic agents for these cells.

公开(公告)号：NO904003A

公开(公告)日：1990-09-13

申请号：NO904003

申请日：1990-09-13

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN MARTIN J ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL

IPC: C07D253/08 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/00 ,  A61P35/00 ,  C07D253/10

CPC classification number: C07D253/10 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/0038

公开(公告)号：AT209187T

公开(公告)日：2001-12-15

申请号：AT95927535

申请日：1995-07-31

Applicant: STANFORD RES INST INT ,  UNIV GLASGOW ,  CANCER RES CAMPAIGN TECH

Inventor： TRACY MICHAEL ,  KELSON ANDREW B ,  WORKMAN PAUL ,  LEWIS ALEXANDER D ,  ABOAGYE ERIC O

IPC: A61K49/00 ,  A61K49/06 ,  C07D233/91 ,  C07H13/04 ,  C07H15/04 ,  A61K31/415 ,  C07H5/04 ,  A61K31/70

Abstract: Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) (I) Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.

公开(公告)号：NO179005C

公开(公告)日：1996-07-17

申请号：NO904003

申请日：1990-09-13

Applicant: STANFORD RES INST INT

Inventor： LEE WILLIAM W ,  BROWN J MARTIN ,  GRANGE EDWARD W ,  MARTINEZ ABELARDO P ,  TRACY MICHAEL

IPC: C07D253/08 ,  A61K31/53 ,  A61K31/5377 ,  A61K41/00 ,  A61P35/00 ,  C07D253/10

Abstract: A method of using 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents is disclosed. The compounds are shown to specifically radiosensitive hypoxic tumor cells and are additionnally disclosed to be useful as specific cytotoxic agents for these cells.