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    ELECTROCHEMICAL BIOSENSOR
    1.
    发明申请
    ELECTROCHEMICAL BIOSENSOR 审中-公开
    电化学生物传感器

    公开(公告)号：WO2009097174A2

    公开(公告)日：2009-08-06

    申请号：PCT/US2009030304

    申请日：2009-01-07

    Applicant: STC UNM ,  SITDIKOV RAVIL ,  IVNITSKIV DMITRI ,  LOPEZ GABRIEL ,  RAMIREZ BRIANNA ,  ATANASSOV PLAMEN

    Inventor： SITDIKOV RAVIL ,  IVNITSKIV DMITRI ,  LOPEZ GABRIEL ,  RAMIREZ BRIANNA ,  ATANASSOV PLAMEN

    IPC: G01N27/327 ,  G01N27/28 ,  G01N27/41 ,  G01N33/48

    CPC classification number: G01N33/557 ,  B82Y5/00 ,  G01N2333/11

    Abstract: A simple, fast, selective and highly sensitive electrochemical method assay and disposable device for detection of viruses, bacteria, proteins, DNA, and/or organic/inorganic compounds. The sensor has a multi-layered construction, with each successive layer performing a different function. The design further allows for the packing of numerous microscopic electrode transducers onto the small footprint of a biochip device, allowing for a high-density array of sensors.

    Abstract translation: 用于检测病毒，细菌，蛋白质，DNA和/或有机/无机化合物的简单，快速，选择性和高度灵敏的电化学方法测定和一次性装置。 该传感器具有多层结构，每个连续的层执行不同的功能。 该设计进一步允许将许多微观电极换能器包装到生物芯片装置的小占地面积上，从而允许高密度阵列的传感器。

    STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES AND THEIR USE IN ACOUSTIC RADIATION FIELDS
    7.
    发明申请
    STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES AND THEIR USE IN ACOUSTIC RADIATION FIELDS 审中-公开
    稳定的弹性体负反射粒子及其在声辐射场中的应用

    公开(公告)号：WO2010132474A3

    公开(公告)日：2011-04-21

    申请号：PCT/US2010034415

    申请日：2010-05-11

    Applicant: STC UNM ,  LOPEZ GABRIEL ,  KADUCHAK GREGORY

    Inventor： LOPEZ GABRIEL ,  KADUCHAK GREGORY

    IPC: A61K9/14 ,  A61K9/16 ,  A61K47/30 ,  A61K49/00

    CPC classification number: C08L83/04 ,  A61K9/0009 ,  A61K9/1641 ,  A61K9/1682 ,  A61K47/34 ,  A61K49/225 ,  G01N33/538 ,  G01N33/54313

    Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.

    Abstract translation: 我们描述了具有可压缩性和密度的稳定的弹性体负声学对比粒子的合成方法和配方。 这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。 这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。 本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。 这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。

    SYNTHESIS OF STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES
    8.
    发明申请
    SYNTHESIS OF STABLE ELASTOMERIC NEGATIVE ACOUSTIC CONTRAST PARTICLES 审中-公开
    稳定的弹性负离子对比剂颗粒的合成

    公开(公告)号：WO2010132471A2

    公开(公告)日：2010-11-18

    申请号：PCT/US2010034411

    申请日：2010-05-11

    Applicant: STC UNM ,  LOPEZ GABRIEL ,  CARROLL NICK ,  CUSHING KEVIN ,  PETSEV DIMITER N

    Inventor： LOPEZ GABRIEL ,  CARROLL NICK ,  CUSHING KEVIN ,  PETSEV DIMITER N

    IPC: A61K9/14 ,  A61K9/16 ,  A61K47/30 ,  A61K49/00

    CPC classification number: C08L83/04 ,  A61K9/0009 ,  A61K9/1641 ,  A61K9/1682 ,  A61K47/34 ,  A61K49/225 ,  G01N33/538 ,  G01N33/54313

    Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays. Potential applications of these elastomeric negative acoustic contrast particles include sensitive bioassays based on acoustic flow cytometry and other types of techniques that utilize acoustic fields, including ultrasound imaging and ultrasound triggered drug delivery.

    Abstract translation: 我们描述了具有可压缩性和密度的稳定的弹性体负声学对比粒子的合成方法和配方。 这些弹性体负声学对比颗粒的密度/压缩比小于水的密度/压缩比，因此在声辐射暴露下呈现负的声学对比度。 这种负声学对比度允许我们的弹性体负声学对比粒子与水溶液中的其它组分（例如细胞）不同地被声学操纵（例如分离）。 本公开还描述了弹性体负声学对比粒子的生物功能化的方法，并且作为其用作生物测定平台的实例。 这些弹性体负声学对比粒子的潜在应用包括基于声流式细胞术的敏感生物测定和利用声场的其他类型的技术，包括超声成像和超声触发药物递送。

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