公开(公告)号：WO2011041500A3

公开(公告)日：2011-08-18

申请号：PCT/US2010050850

申请日：2010-09-30

Applicant: STC UNM ,  LUAN SHUANG ,  MA LIJUN ,  CHEN ZHE

Inventor： LUAN SHUANG ,  MA LIJUN ,  CHEN ZHE

IPC: A61N5/10 ,  A61B5/05 ,  A61B6/00

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

Abstract translation: 基于光子的放射外科广泛用于治疗局部和区域肿瘤。 提高放射外科手术质量的关键是增加肿瘤内高剂量区域的剂量衰减率到附近健康组织和结构的低剂量区域。 动态光子喷涂（DPP）通过沿着动态轨迹移动光束源来处理目标，从而进一步提高剂量衰减率，其中在照射期间光源的速度，方向和剂量率恒定不变。 DPP制造的剂量梯度可以与质子布拉格峰相媲美，并且胜过伽玛刀放射外科手术。

公开(公告)号：WO2009137010A3

公开(公告)日：2010-02-18

申请号：PCT/US2009002733

申请日：2009-05-04

Applicant: STC UNM ,  LUAN SHUANG ,  SWANSON NATHAN ,  MA LIJUN

Inventor： LUAN SHUANG ,  SWANSON NATHAN ,  MA LIJUN

IPC: A61B19/00 ,  A61B6/00 ,  A61B18/00

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of "dose-painting" to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical "paintbrush", and treatment planning is reduced to finding the best route of this "paintbrush" to "paint" a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Abstract translation: 本发明是基于“剂量绘画”的概念，利用伽玛刀C和Perfexion单元上的机器人患者定位系统开发伽玛刀放射外科的动态方案的方法和系统。 由Gamma Knife单元创建的球形高剂量体积将被视为3D球形“画笔”，并且减少治疗计划以找到该“画笔”将“绘制”3D肿瘤体积的最佳路线。 在剂量绘画概念下，伽玛刀放射外科手术变得动态，患者在机器人定位系统下连续移动。

公开(公告)号：WO2011139829A3

公开(公告)日：2012-04-05

申请号：PCT/US2011034312

申请日：2011-04-28

Applicant: STC UNM ,  KEYES ROY WILLIAM ,  ROMANO CHRISTIAN ,  LUAN SHUANG ,  ARNOLD DORIAN C

Inventor： KEYES ROY WILLIAM ,  ROMANO CHRISTIAN ,  LUAN SHUANG ,  ARNOLD DORIAN C

IPC: G06F19/00 ,  G06F15/16

CPC classification number: G06F19/3481 ,  G06F9/5083 ,  G06F19/3437 ,  G16H50/50

Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.

Abstract translation: 提出了一种在网络虚拟计算群上计算辐射能量密度和能量沉积分布的方法。 通过这种方法，复杂的蒙特卡洛模拟需要广泛的设备，人员和财务资源，可以由需要放射治疗剂量计算的医院和诊所进行有效和低成本的处理。

公开(公告)号：EP2278933A4

公开(公告)日：2017-08-09

申请号：EP09742997

申请日：2009-05-04

Applicant: STC UNM

Inventor： LUAN SHUANG ,  SWANSON NATHAN ,  MA LIJUN

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of "dose-painting" to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical "paintbrush", and treatment planning is reduced to finding the best route of this "paintbrush" to "paint" a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Abstract translation: 本发明是基于“剂量绘画”概念开发用于伽玛刀放射手术的动态方案以利用伽马刀C和Perfexion单元上的机器人患者定位系统的方法和系统。 由伽玛刀单元创建的球形高剂量体积将被视为3D球形“画笔”，并且治疗计划被缩减为找到该“画笔”来“绘制”3D肿瘤体积的最佳路线。 在剂量绘画的概念下，伽玛刀放射手术变得动态，患者在机器人定位系统下持续移动。