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公开(公告)号：WO2012037397A2
公开(公告)日：2012-03-22
申请号：PCT/US2011051827
申请日：2011-09-15
Applicant: STC UNM , PAUL SUROJIT
Inventor： PAUL SUROJIT
CPC classification number: C12N9/16 , A61K38/00 , A61K38/465 , C12Y301/03048
Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.
Abstract translation: 显示和描述了作为神经元特异性酪氨酸磷酸酶的修饰衍生物的新型肽序列。 具体来说，新肽序列是纹状体富含酪氨酸磷酸酶的修饰衍生物（STEP）。 肽序列已被修饰，以便能够改善和治疗由过量的谷氨酸释放和/或氧化应激引起的脑损伤。 目前公开的肽序列可用于治疗的脑损伤类型的实例包括由中风或创伤性脑损伤引起的急性脑损伤和慢性疾病如亨廷顿氏舞蹈症和精神分裂症。 此外，目前描述的肽序列还可用于治疗和改善与恐惧记忆相关的疾病，例如创伤后应激障碍。
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公开(公告)号：CA2811086A1
公开(公告)日：2012-03-22
申请号：CA2811086
申请日：2011-09-15
Applicant: STC UNM
Inventor： PAUL SUROJIT
Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.
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公开(公告)号：CA2811086C
公开(公告)日：2020-07-21
申请号：CA2811086
申请日：2011-09-15
Applicant: STC UNM
Inventor： PAUL SUROJIT
Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.
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公开(公告)号：EP2616485A4
公开(公告)日：2014-04-02
申请号：EP11825972
申请日：2011-09-15
Applicant: STC UNM
Inventor： PAUL SUROJIT
CPC classification number: C12N9/16 , A61K38/00 , A61K38/465 , C12Y301/03048
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