公开(公告)号：WO2008008383A3

公开(公告)日：2008-10-30

申请号：PCT/US2007015802

申请日：2007-07-11

Applicant: STC UNM ,  TIMMINS GRAHAM S

Inventor： TIMMINS GRAHAM S

IPC: A61K9/00 ,  A61B5/05 ,  C12M1/34 ,  C12Q1/02

CPC classification number: A61K49/0008 ,  A61B5/0059 ,  A61B5/444 ,  A61B5/445 ,  G01R33/60

Abstract: The present invention is a system and methods of establishing a Melanocyte Protection Factor (MPF), which indicates the level of protection against DNA damage to a target cell, such as the level of protection a particular sunscreen offers against UVA rays when compared to the unprotected case, i.e., no sunscreen. The present invention determines and records levels of stable melanin radicals (SMR) in a target cell. Light is applied to the target cell forming light-induced melanin radicals (LIR). The levels of SMR and intensity of LIR are measured to determine the amount of incident light reaching the target cell. Since LIR is proportional to the square root of light intensity reaching the target cell, the ratio of light reaching the target cell is defined as the MPF (I).

公开(公告)号：WO2008008383A9

公开(公告)日：2008-03-27

申请号：PCT/US2007015802

申请日：2007-07-11

Applicant: STC UNM ,  TIMMINS GRAHAM S

Inventor： TIMMINS GRAHAM S

IPC: C12Q1/00

CPC classification number: A61K49/0008 ,  A61B5/0059 ,  A61B5/444 ,  A61B5/445 ,  G01R33/60

Abstract: The present invention is a system and methods of establishing a Melanocyte Protection Factor (MPF), which indicates the level of protection against DNA damage to a target cell, such as the level of protection a particular sunscreen offers against UVA rays when compared to the unprotected case, i.e., no sunscreen. The present invention determines and records levels of stable melanin radicals (SMR) in a target cell. Light is applied to the target cell forming light-induced melanin radicals (LIR). The levels of SMR and intensity of LIR are measured to determine the amount of incident light reaching the target cell. Since LIR is proportional to the square root of light intensity reaching the target cell, the ratio of light reaching the target cell is defined as the MPF (I).

Abstract translation: 本发明是建立黑素细胞保护因子（MPF）的系统和方法，其表明针对靶细胞的DNA损伤的保护水平，例如与未受保护的相比，特定防晒剂针对UVA射线提供的保护水平 案例，即没有防晒霜。 本发明确定并记录靶细胞中稳定的黑色素自由基（SMR）的水平。 光照射到靶细胞形成光诱导黑素自由基（LIR）。 测量SMR的水平和LIR的强度以确定到达目标细胞的入射光的量。 由于LIR与到达目标细胞的光强度的平方根成比例，所以到达目标细胞的光的比率被定义为MPF（I）。

公开(公告)号：CA2567125A1

公开(公告)日：2005-12-15

申请号：CA2567125

申请日：2005-06-01

Applicant: STC UNM

Inventor： TIMMINS GRAHAM S

IPC: A61B6/00 ,  A61B5/05 ,  A61B5/055 ,  A61B5/103

Abstract: Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to image a melanoma. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to detect metastatic melanoma in a sentinel lymph node. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to measure light penetration in melanocytes in skin.

公开(公告)号：GB2430267B

公开(公告)日：2008-11-26

申请号：GB0622266

申请日：2005-06-01

Applicant: UNIV NEW MEXICO ,  SCIENCE & TECHNOLOGY CORP AT U ,  STC UNM A NON PROFIT CORP UNDE

Inventor： TIMMINS GRAHAM S

IPC: A61B5/055 ,  A61B5/05 ,  A61B5/103 ,  G01R33/60

Abstract: Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to image a melanoma. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to detect metastatic melanoma in a sentinel lymph node. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to measure light penetration in melanocytes in skin.