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    PROCESS AND CATALYSTS FOR THE CONJUGATION OF DOUBLE BONDS IN FATTY ACIDS AND DERIVATIVES THEREOF
    1.
    发明申请
    PROCESS AND CATALYSTS FOR THE CONJUGATION OF DOUBLE BONDS IN FATTY ACIDS AND DERIVATIVES THEREOF 审中-公开
    脂肪酸和其衍生物双重结合的过程和催化剂

    公开(公告)号：WO2006101473A1

    公开(公告)日：2006-09-28

    申请号：PCT/US2005/008639

    申请日：2005-03-15

    Applicant: STEPAN COMPANY ,  RONGIONE, Joseph C.

    Inventor： RONGIONE, Joseph C.

    IPC: C11C3/14 ,  C07C51/353 ,  C07C67/333 ,  B01J31/02

    CPC classification number: B01J31/0252 ,  B01J31/0204 ,  B01J31/0212 ,  B01J2531/12 ,  B01J2531/13 ,  C11C3/14

    Abstract: A process to manufacture conjugated fatty acids or their derivatives, in particular long chain polyunsaturated fatty acids (e.g., CLAs) or their derivatives, using an improved catalyst system that isomerizes the fatty acids and their derivatives in an efficient, cost-effective manner. The improved catalyst system includes a metal alkoxide or amide catalyst chelated with an appropriate chelating agent or a metal alkoxide formed from another metal alkoxide in the described process.

    Abstract translation: 使用改进的催化剂体系制造共轭脂肪酸或其衍生物，特别是长链多不饱和脂肪酸（例如CLA）或其衍生物的方法，其以有效，成本有效的方式异构化脂肪酸及其衍生物。 改进的催化剂体系包括在所述方法中与合适的螯合剂或由另一种金属醇盐形成的金属醇盐螯合的金属醇盐或酰胺催化剂。

    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS
    2.
    发明申请
    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS 审中-公开
    共混盐酸盐和酸的制备

    公开(公告)号：WO2004101719A2

    公开(公告)日：2004-11-25

    申请号：PCT/US2004/012387

    申请日：2004-04-21

    Applicant: STEPAN COMPANY ,  RONGIONE, Joseph C. ,  GALANTE, Jenifer Heydinger ,  CLAUSS, Steven L. ,  BERNHARDT, Randal J. ,  XAYARIBOUN, Phouvieng

    Inventor： RONGIONE, Joseph C. ,  GALANTE, Jenifer Heydinger ,  CLAUSS, Steven L. ,  BERNHARDT, Randal J. ,  XAYARIBOUN, Phouvieng

    IPC: C11C

    CPC classification number: C07C51/09 ,  C07C57/12

    Abstract: A process to manufacture conjugated linoleic acid (CLA)-containing materials including conjugated linoleic salts and acids that are enriched in desirable cis-9, trans-11- and trans-10, cis-12-CLA isomers and are low in certain undesirable isomers. The process generally entails isomerization of an alkyl ester of a linoleic acid-containing material, such as sunflower oil or safflower oil, to effectuate conjugation of the double bonds, followed by saponification of the resultant CLA-containing fatty acid ester to produce a CLA-containing fatty acid salt, optionally followed by neutralization of the CLA-containing fatty acid salt with an acid source to produce a CLA-containing fatty acid.

    Abstract translation: 包含共轭亚油酸盐和酸的共轭亚油酸（CLA）材料的制备方法，其富含希望的顺式-9，反式-11-和反式-10，顺式-12-CLA异构体，并且在某些不需要的异构体中是低的 。 该方法通常需要含亚油酸的材料的烷基酯如向日葵油或红花油的异构化，以实现双键的缀合，然后将所得的含CLA脂肪酸酯皂化以产生CLA- 任选地随后用酸源中和含CLA的脂肪酸盐以产生含CLA的脂肪酸。

    GLYCERIDE ESTERS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH REDUCED NEURONAL METABOLISM OF GLUCOSE
    3.
    发明申请
    GLYCERIDE ESTERS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH REDUCED NEURONAL METABOLISM OF GLUCOSE 审中-公开
    用于治疗与减少葡萄糖的神经代谢有关的疾病的甘油三酯

    公开(公告)号：WO2008005818A1

    公开(公告)日：2008-01-10

    申请号：PCT/US2007/072441

    申请日：2007-06-29

    Applicant: STEPAN COMPANY ,  HASHIM, Sami A. ,  JUSIS, Joanna ,  HEYDINGER GALANTE, Jenifer ,  RONGIONE, Joseph C.

    Inventor： HASHIM, Sami A. ,  JUSIS, Joanna ,  HEYDINGER GALANTE, Jenifer ,  RONGIONE, Joseph C.

    IPC: A61K31/22 ,  A61K47/00

    CPC classification number: A61K31/22

    Abstract: Provided are alternative sources of ketone bodies for reducing or eliminating symptoms of Parkinson's disease, amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's disease), Alzheimer's disease, Huntington's disease, epilepsy and other diseases or disorders characterized by impaired glucose metabolism. The alternative sources of ketone bodies include mono-, di- and triglyceride esters of acetoacetate and mixtures thereof, and/or mono-, di- and triglyceride esters of 3-hydroxybutyrate and mixtures thereof. These glyceride esters can be administered orally as a dietary supplement or in a nutritional composition.

    Abstract translation: 提供用于减少或消除帕金森病，肌萎缩性侧索硬化（ALS，也称为Lou Gehrig病），阿尔茨海默病，亨廷顿病，癫痫以及以葡萄糖代谢紊乱为特征的其他疾病或病症的症状的酮体的替代来源。 酮体的替代来源包括乙酰乙酸酯的单酯，二甘油酯和甘油三酸酯及其混合物，和/或3-羟基丁酸酯的单酯，二甘油三酯和甘油三酯及其混合物。 这些甘油酯可以作为膳食补充剂或营养组合物口服给药。

    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS
    6.
    发明授权
    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS 有权
    制造和共轭亚油酸LINOLSÄURESALZEN

    公开(公告)号：EP1620384B1

    公开(公告)日：2009-07-15

    申请号：EP04760826.0

    申请日：2004-04-21

    Applicant: STEPAN COMPANY

    Inventor： RONGIONE, Joseph C. ,  GALANTE, Jenifer Heydinger ,  CLAUSS, Steven L. ,  BERNHARDT, Randal J. ,  XAYARIBOUN, Phouvieng

    IPC: C07C51/347

    CPC classification number: C07C51/09 ,  C07C57/12

    Abstract: A process to manufacture conjugated linoleic acid (CLA)-containing materials including conjugated linoleic salts and acids that are enriched in desirable cis-9, trans-11- and trans-10, cis-12-CLA isomers and are low in certain undesirable isomers. The process generally entails isomerization of an alkyl ester of a linoleic acid-containing material, such as sunflower oil or safflower oil, to effectuate conjugation of the double bonds, followed by saponification of the resultant CLA-containing fatty acid ester to produce a CLA-containing fatty acid salt, optionally followed by neutralization of the CLA-containing fatty acid salt with an acid source to produce a CLA-containing fatty acid.

    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS
    8.
    发明公开
    MANUFACTURE OF CONJUGATED LINOLEIC SALTS AND ACIDS 有权
    共轭亚油酸盐和酸的制造

    公开(公告)号：EP1620384A2

    公开(公告)日：2006-02-01

    申请号：EP04760826.0

    申请日：2004-04-21

    Applicant: STEPAN COMPANY

    Inventor： RONGIONE, Joseph C. ,  GALANTE, Jenifer Heydinger ,  CLAUSS, Steven L. ,  BERNHARDT, Randal J. ,  XAYARIBOUN, Phouvieng

    IPC: C07C51/347

    CPC classification number: C07C51/09 ,  C07C57/12

    Abstract: A process to manufacture conjugated linoleic acid (CLA)-containing materials including conjugated linoleic salts and acids that are enriched in desirable cis-9, trans-11- and trans-10, cis-12-CLA isomers and are low in certain undesirable isomers. The process generally entails isomerization of an alkyl ester of a linoleic acid-containing material, such as sunflower oil or safflower oil, to effectuate conjugation of the double bonds, followed by saponification of the resultant CLA-containing fatty acid ester to produce a CLA-containing fatty acid salt, optionally followed by neutralization of the CLA-containing fatty acid salt with an acid source to produce a CLA-containing fatty acid.

    Abstract translation: 一种生产共轭亚油酸（CLA）的材料的方法，所述共轭亚油酸包含共轭亚油酸盐和富含所需顺式-9，反式11和反式10，顺式-12-CLA异构体并且某些不希望的异构体 。 该方法通常需要使含有亚油酸的物质如葵花油或红花油的烷基酯异构化以实现双键的共轭，接着皂化所得的含CLA的脂肪酸酯以产生CLA- 随后用酸源中和含CLA的脂肪酸盐以产生含CLA的脂肪酸。

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