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    Biomimetic networks comprising polyisocyanopeptide hydrogels
    1.
    发明授权
    Biomimetic networks comprising polyisocyanopeptide hydrogels 有权

    公开(公告)号：US11053349B2

    公开(公告)日：2021-07-06

    申请号：US16466366

    申请日：2017-12-05

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： Paul Kouwer ,  Alan Edward Rowan ,  Daniël Schoenmakers

    IPC: C08G61/04 ,  A61L27/52 ,  C08G65/333 ,  C12N5/00

    Abstract: A polymer hydrogel having a polymer formed by the crosslinking reaction of a polymeric unit A according to formula (I), with a crosslinking unit B according to formula (II) and water, wherein n=100-10,000, preferable 250-2500, more preferable 500-1500; m=independently 2-10, preferably 3 or 4; FG is a functional moiety that can be covalently coupled to the complementary functional moiety F1 or F2 of the crosslinking unit (B); k=0.01-0.05; h=0, 1 or 2; the spacer is an organic moiety, having a main chain comprising at least two functional moieties F1 and F2, wherein the length of the crosslinker in the extended conformation as determined by molecular modeling (including spacer and functional groups F1 and F2) is between 2.5 and 12 nm, or wherein the length is between 20 and 80 atoms.

    METHOD FOR THE PREPARATION OF HIGH MOLECULAR WEIGHT OLIGO(ALKYLENE GLYCOL) FUNCTIONALIZED POLYISOCYANOPEPTIDES
    2.
    发明申请
    METHOD FOR THE PREPARATION OF HIGH MOLECULAR WEIGHT OLIGO(ALKYLENE GLYCOL) FUNCTIONALIZED POLYISOCYANOPEPTIDES 审中-公开
    制备高分子量OLIGO（亚苄基甘油）官能化聚异氰尿酸酯的方法

    公开(公告)号：US20150105516A1

    公开(公告)日：2015-04-16

    申请号：US14577038

    申请日：2014-12-19

    Applicant: Stichting Katholieke Universiteit Meer in Het Bijzonder Radboud University Nijmegen

    Inventor： Alan Edward Rowan ,  Roeland Johannes Maria Nolte ,  Jeroen Johannes Lambertus Maria Cornelissen ,  Heather Joy Kitto ,  Erik Schwartz ,  Matthieu Koepf

    IPC: C08G69/40 ,  C09D177/04 ,  C08L77/04

    CPC classification number: C08G69/40 ,  C08G65/33348 ,  C08L77/04 ,  C08L2201/54 ,  C09D177/04

    Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.

    Abstract translation: 本发明涉及制备低聚（亚烷基二醇）官能化多异氰酸肽的方法，其包括以低聚（亚烷基二醇）侧链官能化异氰尿酸并随后聚合低聚 - 亚烷基二醇官能化的异氰尿苷的步骤。 可以用具有可变链长度的各种线性或非线性寡（亚烷基二醇）侧链来官能化几种异氰酸酯。 亚烷基二醇可以选自乙烯 - ，丙烯 - ，丁烯 - 或戊二醇。 优选地，异氰酸肽用至少三个乙二醇侧链进行官能化。 肽可以包含L-氨基酸，D-氨基酸或D，L-氨基酸。 获得的低聚亚烷基官能化多异氰酸肽是具有独特热响应特性的新一类材料。

    Polymer suitable for use in cell culture
    3.
    发明授权
    Polymer suitable for use in cell culture 有权

    公开(公告)号：US10266809B2

    公开(公告)日：2019-04-23

    申请号：US14905579

    申请日：2014-07-16

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： Alan Edward Rowan ,  Zaskia Hillet Eksteen Akeroyd ,  Christopher Wilson ,  Petrus Johannes Geutjes ,  Wouter F. J. Feitz ,  Egbert Oosterwijk

    IPC: C12N5/071 ,  C08G65/325 ,  C08G65/333 ,  C08G69/10 ,  C08G69/40 ,  C07K5/062

    Abstract: A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin-strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol-carboxylic acid coupling resulting in esters linkages and NHS-Ester (N-Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.

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