公开(公告)号：US11840705B2

公开(公告)日：2023-12-12

申请号：US16607824

申请日：2018-04-23

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： Paul Kouwer ,  Alan Rowan ,  Maarten Jaspers ,  Paula De Almeida

IPC: C12N5/18 ,  C12N5/00 ,  C09D133/26 ,  C08J3/24 ,  C08F120/54

CPC classification number: C12N5/0018 ,  C08F120/54 ,  C08J3/246 ,  C09D133/26 ,  C08J2333/02 ,  C08J2333/26 ,  C08J2477/04 ,  C12N2533/40 ,  C12N2533/54

Abstract: A double network hydrogel including a polymer (A) having a persistence length between 10 and 1000 nm; a flexible polymer (B), wherein the persistence length is measured according to single molecule force microscopy measurement, wherein polymer (B) has an extended coil conformation at a first condition and a collapsed globular conformation at a second condition. Polymer (A) preferably is a polyisocyanate, while polymer (B) is a crosslinked flexible polymer like for example PNIPAM. A method for making a double network hydrogel.

公开(公告)号：US11053349B2

公开(公告)日：2021-07-06

申请号：US16466366

申请日：2017-12-05

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： Paul Kouwer ,  Alan Edward Rowan ,  Daniël Schoenmakers

IPC: C08G61/04 ,  A61L27/52 ,  C08G65/333 ,  C12N5/00

Abstract: A polymer hydrogel having a polymer formed by the crosslinking reaction of a polymeric unit A according to formula (I), with a crosslinking unit B according to formula (II) and water, wherein n=100-10,000, preferable 250-2500, more preferable 500-1500; m=independently 2-10, preferably 3 or 4; FG is a functional moiety that can be covalently coupled to the complementary functional moiety F1 or F2 of the crosslinking unit (B); k=0.01-0.05; h=0, 1 or 2; the spacer is an organic moiety, having a main chain comprising at least two functional moieties F1 and F2, wherein the length of the crosslinker in the extended conformation as determined by molecular modeling (including spacer and functional groups F1 and F2) is between 2.5 and 12 nm, or wherein the length is between 20 and 80 atoms.