公开(公告)号：US20180185485A1

公开(公告)日：2018-07-05

申请号：US15740194

申请日：2016-07-01

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： Mangala SRINIVAS ,  Carl Gustav FIGDOR ,  Ingrid Jolanda Monique DE VRIES

IPC: A61K41/00 ,  A61K49/22 ,  A61N7/02

CPC classification number: A61K41/0028 ,  A61K49/222 ,  A61N7/02

Abstract: In the field of medical therapy, more in particular in the field of ablation therapy using ultrasound, such as high intensity focused ultrasound (HIFU), devices and methods are disclosed for enhancing the ablation effect of HIFU. More in particular, a polymeric particle is disclosed, including a polymer entrapping a liquid perfluorocarbon for use in high frequency ultrasound (HIFU) ablation therapy in a human or animal body, wherein the HIFU is focused in a focal region, wherein the ablation effect of the HIFU in the focal region is enhanced by administering the particles to the human or animal body, and the liquid perfluorocarbon does not undergo a phase change from liquid to gas during exposure to the HIFU.

公开(公告)号：US20190077925A1

公开(公告)日：2019-03-14

申请号：US16083576

申请日：2017-03-13

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： Mangala SRINIVAS ,  Olga KOSHKINA ,  Carl Gustav FIGDOR ,  Ingrid Jolanda Monique DE VRIES

IPC: C08J3/205 ,  C08J3/09 ,  A61K49/22 ,  A61K49/18

Abstract: A process for the preparation of beads including a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohol and optionally a metal compound, including the steps of: adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, adding the first liquid mixture to an aqueous solution of a biocompatible surfactant including polyvinylalcohol under sonication to obtain a second liquid mixture, a) maintaining the sonication of the second liquid mixture while cooling, b) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads including the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, c) separating the beads from the suspension and preparing a water suspension of the beads and d) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most 10 seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. Beads having close F-H2O interactions, which are suitable for imaging purposes.