公开(公告)号：US20190077925A1

公开(公告)日：2019-03-14

申请号：US16083576

申请日：2017-03-13

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： Mangala SRINIVAS ,  Olga KOSHKINA ,  Carl Gustav FIGDOR ,  Ingrid Jolanda Monique DE VRIES

IPC: C08J3/205 ,  C08J3/09 ,  A61K49/22 ,  A61K49/18

Abstract: A process for the preparation of beads including a biocompatible hydrophobic polymer, a perfluorocarbon, polyvinylalcohol and optionally a metal compound, including the steps of: adding the perfluorocarbon and optionally the metal compound to a solution of the biocompatible hydrophobic polymer in a polar solvent to provide a first liquid mixture, adding the first liquid mixture to an aqueous solution of a biocompatible surfactant including polyvinylalcohol under sonication to obtain a second liquid mixture, a) maintaining the sonication of the second liquid mixture while cooling, b) evaporating the polar solvent from the second liquid mixture to obtain a suspension of beads including the biocompatible hydrophobic polymer, the perfluorocarbon and optionally the metal compound, c) separating the beads from the suspension and preparing a water suspension of the beads and d) freeze-drying the water suspension to obtain the beads, wherein the addition of the first liquid mixture to the biocompatible surfactant in step b) is performed within a period of at most 10 seconds, wherein the sonication in step b) and the sonication in step c) are performed directly into the liquid mixtures by for example a probe or flow sonicator at an amplitude of at least 120 μm for 0.01-10 minutes and wherein the weight ratio of the biocompatible surfactant to the biocompatible hydrophobic polymer is at least 3:1. Beads having close F-H2O interactions, which are suitable for imaging purposes.