公开(公告)号：WO2008026915A2

公开(公告)日：2008-03-06

申请号：PCT/NL2007000211

申请日：2007-08-29

Applicant: STICHTING TECH WETENSCHAPP ,  SMIJS GEERTRUIDA MARIA THERESI ,  SCHUITMAKER JOHANNES

Inventor： SMIJS GEERTRUIDA MARIA THERESI ,  SCHUITMAKER JOHANNES

IPC: A61K31/409 ,  A61K41/00 ,  A61P31/10

CPC classification number: A61K31/409 ,  A61K41/0071 ,  A61K2300/00

Abstract: The present invention relates to a pharmaceutical composition for photodynamic treatment of a fungal skin disorder, said pharmaceutical composition comprising a photosensitizer and an enhancer, wherein the photosensitizer is a cationic photosensitizer and the enhancer is chosen from the group of i) an acid, and ii) a metal chelating agent. Such a composition is capable of eliminating both conidiae and hy- phae. The invention also relates to a method for the preparation of the pharmaceutical composition.

Abstract translation: 本发明涉及一种用于光动力治疗真菌皮肤病症的药物组合物，所述药物组合物包含光敏剂和增强剂，其中所述光敏剂是阳离子光敏剂，增强剂选自i）酸和ii ）金属螯合剂。 这种组合物能够消除分生孢子和海藻。 本发明还涉及制备药物组合物的方法。

公开(公告)号：AT454146T

公开(公告)日：2010-01-15

申请号：AT07808509

申请日：2007-08-29

Applicant: STICHTING TECH WETENSCHAPP

Inventor： SMIJS GEERTRUIDA ,  SCHUITMAKER JOHANNES

IPC: A61K31/409 ,  A61K41/00 ,  A61P31/10

Abstract: The present invention relates to a pharmaceutical composition for photodynamic treatment of a fungal skin disorder, said pharmaceutical composition comprising a photosensitizer and an enhancer, wherein the photosensitizer is a cationic photosensitizer and the enhancer is chosen from the group of i) an acid, and ii) a metal chelating agent. Such a composition is capable of eliminating both conidiae and hy-phae. The invention also relates to a method for the preparation of the pharmaceutical composition.

公开(公告)号：ES2340818T3

公开(公告)日：2010-06-09

申请号：ES07808509

申请日：2007-08-29

Applicant: STICHTING TECH WETENSCHAPP

Inventor： SMIJS GEERTRUIDA MARIA THERESIA ,  SCHUITMAKER JOHANNES

IPC: A61K31/409 ,  A61K41/00 ,  A61P31/10

Abstract: Una composición farmacéutica para el tratamiento fotodinámico de un trastorno fúngico de la piel, comprendiendo dicha composición farmacéutica un fotosensibilizante y un potenciador, en el que el fotosensibilizante comprende un macrociclo de porfirina que comprende al menos un átomo de nitrógeno cuaternizado, siendo el potenciador un ácido, y presentando la composición farmacéutica un pH de x en el que 3,5

公开(公告)号：DE602007004230D1

公开(公告)日：2010-02-25

申请号：DE602007004230

申请日：2007-08-29

Applicant: STICHTING TECH WETENSCHAPP

Inventor： SMIJS GEERTRUIDA MARIA ,  SCHUITMAKER JOHANNES

IPC: A61K31/409 ,  A61K41/00 ,  A61P31/10

Abstract: The present invention relates to a pharmaceutical composition for photodynamic treatment of a fungal skin disorder, said pharmaceutical composition comprising a photosensitizer and an enhancer, wherein the photosensitizer is a cationic photosensitizer and the enhancer is chosen from the group of i) an acid, and ii) a metal chelating agent. Such a composition is capable of eliminating both conidiae and hy-phae. The invention also relates to a method for the preparation of the pharmaceutical composition.