公开(公告)号：WO2018151601A1

公开(公告)日：2018-08-23

申请号：PCT/NL2018/050110

申请日：2018-02-19

Applicant: STICHTING VUMC

Inventor： WURDINGER, Thomas ,  BEST, Myron Ghislain

IPC: C12Q1/68 ,  C12Q1/6886

Abstract: The invention provides methods of administering immunotherapy that modulates an interaction between PD- i and its ligand, to a cancer patient, based on tumor-educated gene expression profiles obtained from anucleated cells. The invention further provides methods of typing a sample of a subject for the presence or absence of a cancer, based on tumor- educated gene expression profiles obtained from anucleated cells. The invention further provides a method for obtaining a biomarker panel for typing of a sample from a subject using particle swarm optimization-based algorithms.

公开(公告)号：EP3494235A1

公开(公告)日：2019-06-12

申请号：EP18710554.9

申请日：2018-02-19

Applicant: Stichting VUmc

Inventor： WURDINGER, Thomas ,  BEST, Myron Ghislain

IPC: C12Q1/68 ,  C12Q1/6886