公开(公告)号：WO2013123030A2

公开(公告)日：2013-08-22

申请号：PCT/US2013/025912

申请日：2013-02-13

Applicant: STRECK, INC.

Inventor： RYAN, Wayne, L. ,  FERNANDO, M., Rohan ,  DAS, Kausik

IPC: C12Q1/68

CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q2527/125

Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at (east one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the.biological sample while within the sample collection device with a protective agent composition that Includes a preservative agent, an optionai anticoagulant, and a quenching agent to form a mature that: includes the protective agent composition and the sample.

Abstract translation: 用于稳定生物样品用于分析的方法和装置，包括以下步骤：在样品收集装置中获得来自受试者的生物样品，所述生物样品包括（东侧一个来自受试者的无循环的无细胞的第一核酸），所述方法可 包括在样品收集装置内与具有保护剂组合物的生物样品接触的步骤，所述保护剂组合物包括防腐剂，选择性抗凝血剂和猝灭剂，以形成包含保护剂组合物和样品的成熟剂。

公开(公告)号：EP3225699B1

公开(公告)日：2020-09-30

申请号：EP17170896.9

申请日：2013-02-13

Applicant: Streck, Inc.

Inventor： RYAN, Wayne L. ,  FERNANDO, Rohan M. ,  DAS, Kausik

IPC: C12Q1/68

公开(公告)号：EP3225699A1

公开(公告)日：2017-10-04

申请号：EP17170896.9

申请日：2013-02-13

Applicant: Streck, Inc.

Inventor： RYAN, Wayne L. ,  FERNANDO, Rohan M. ,  DAS, Kausik

IPC: C12Q1/68

Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the biological sample while within the sample collection device with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

Abstract translation: 用于稳定用于分析的生物样品的方法和装置，包括以下步骤：在样品收集装置中获得来自对象的生物样品，所述生物样品包括来自所述对象的至少一种无循环细胞的第一核酸。 该方法可以包括在样品收集装置内将生物样品与包含防腐剂，任选抗凝剂和猝灭剂的保护剂组合物接触以形成包含保护剂组合物和样品的混合物的步骤。

公开(公告)号：EP3789499A1

公开(公告)日：2021-03-10

申请号：EP20197453.2

申请日：2013-02-13

Applicant: Streck, Inc.

Inventor： RYAN, Wayne L. ,  FERNANDO, Rohan M. ,  DAS, Kausik

IPC: C12Q1/68

Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the biological sample while within the sample collection device with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

公开(公告)号：EP2814981B1

公开(公告)日：2017-06-28

申请号：EP13706856.5

申请日：2013-02-13

Applicant: Streck, Inc.

Inventor： RYAN, Wayne, L. ,  FERNANDO, M., Rohan ,  DAS, Kausik

IPC: C12Q1/68

CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q2527/125

Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at least one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the biological sample while within the sample collection device with a protective agent composition that includes a preservative agent, an optional anticoagulant, and a quenching agent to form a mixture that includes the protective agent composition and the sample.

Abstract translation: 用于稳定用于分析的生物样品的方法和装置，包括以下步骤：在样品收集装置中获得来自对象的生物样品，所述生物样品包括来自所述对象的至少一种无循环细胞的第一核酸。 该方法可以包括在样品收集装置内将生物样品与包含防腐剂，任选抗凝剂和猝灭剂的保护剂组合物接触以形成包含保护剂组合物和样品的混合物的步骤。

公开(公告)号：EP2814981A2

公开(公告)日：2014-12-24

申请号：EP13706856.5

申请日：2013-02-13

Applicant: Streck Inc.

Inventor： RYAN, Wayne, L. ,  FERNANDO, M., Rohan ,  DAS, Kausik

IPC: C12Q1/68

CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q2527/125

Abstract: Methods and devices for stabilizing a biological sample for analysis, comprising the steps of obtaining in a sample collection device a biological sample from a subject, the biological sample including at (east one circulating cell-free first nucleic acid from the subject. The methods may include a step of contacting the.biological sample while within the sample collection device with a protective agent composition that Includes a preservative agent, an optionai anticoagulant, and a quenching agent to form a mature that: includes the protective agent composition and the sample.

Abstract translation: 用于稳定用于分析的生物样品的方法和装置，包括以下步骤：在样品收集装置中获得来自受试者的生物样品，所述生物样品包括来自所述受试者的至少一种循环的无细胞的第一核酸。 所述方法可以包括在样品收集装置内与包含防腐剂，任选的抗凝血剂和猝灭剂的保护剂组合物接触生物样品以形成包含保护剂组合物和样品的混合物的步骤。