公开(公告)号：WO2016199169A1

公开(公告)日：2016-12-15

申请号：PCT/IN2016/050175

申请日：2016-06-08

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD

Inventor： MA, Wen Wee ,  ADJEI, Alex ,  BUI, Lynne ,  HARNING, Ronald ,  KHOPADE, Ajay ,  BHOWMICK, Subhas ,  ARULSUDAR, Natarajan ,  LAKKAD, Narendra

IPC: A61K9/107 ,  A61K9/51 ,  A61K31/337

CPC classification number: A61K9/10 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/337 ,  A61K47/10 ,  A61K47/12 ,  A61K47/28 ,  A61K47/32 ,  A61P35/00

Abstract: A method of treating patients suffering from carcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is locally advanced or metastatic, by intravenously administering to the patient, paclitaxel in the form of a nanodispersion. The nanodispersion comprises particles with a mean particle size less than 300 nm and is free of polyoxyethylated castor oil and free of a protein.

Abstract translation: 通过静脉内施用纳米分散体形式的紫杉醇，治疗局部晚期或转移的肝内或肝外胆管癌或胆囊癌患者的方法。 纳米分散体包含平均粒度小于300nm的颗粒，并且不含聚氧乙烯化蓖麻油并且不含蛋白质。