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公开(公告)号：US11951106B2
公开(公告)日：2024-04-09
申请号：US17304309
申请日：2021-06-17
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Ajay Jaysingh Khopade , Arindam Halder
CPC classification number: A61K31/498 , A61K9/0048 , A61K9/0051 , A61K9/08 , A61K9/1635 , A61K9/5176 , A61K45/06 , B01J39/20 , A61K31/498 , A61K2300/00
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
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公开(公告)号：US11931359B2
公开(公告)日：2024-03-19
申请号：US18061848
申请日：2022-12-05
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Ajay Jaysingh Khopade , Arindam Halder
CPC classification number: A61K31/498 , A61K9/0048 , A61K9/0051 , A61K9/08 , A61K9/1635 , A61K9/5176 , A61K45/06 , B01J39/20 , A61K31/498 , A61K2300/00
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
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公开(公告)号：US09539262B2
公开(公告)日：2017-01-10
申请号：US14691167
申请日：2015-04-20
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY, LTD.
Inventor： Ajay Jaysingh Khopade , Arindam Halder , Subhas Balaram Bhowmick
IPC: A61K31/5575 , A61K47/14 , A61K9/00 , A61K9/107 , A61K31/00
CPC classification number: A61K31/5575 , A61K9/0048 , A61K9/1075 , A61K31/00 , A61K47/14
Abstract: The present invention relates to a pharmaceutical composition suitable for ophthalmic use comprising one or more prostaglandin derivatives or salts, a stabilizing amount of polyethylene glycol hydroxystearate and pharmaceutically acceptable vehicle.
Abstract translation: 本发明涉及适用于眼用的药物组合物，其包含一种或多种前列腺素衍生物或盐，稳定量的聚乙二醇羟基硬脂酸酯和药学上可接受的载体。
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公开(公告)号：US20210308130A1
公开(公告)日：2021-10-07
申请号：US17304309
申请日：2021-06-17
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.
Inventor： Ajay Jaysingh Khopade , Arindam Halder
Abstract: The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling into the eye an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters having a D50 value of at least 2 micrometer and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometer to 900 nanometer. The present invention further relates to an aqueous suspension comprising reversible clusters of drug loaded nano-resin particles, said clusters have a D50 value of at least 2 micrometers and said drug loaded nano-resin particles have a particle size distribution characterized in that the D90 value is 70 nanometers to 900 nanometers.
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