公开(公告)号：WO2017056113A1

公开(公告)日：2017-04-06

申请号：PCT/IN2016/050330

申请日：2016-09-30

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： NAIK, Sachin Pushkarray ,  SEJU, Ujjawal Jayantilal ,  BHOWMICK, Subhas Balaram

IPC: A61K31/7048 ,  A61K9/127

CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K31/7048

Abstract: The present invention relates to a process for the preparation of unilamellar liposomal composition of a polyene antibiotic drug, preferably amphotericin B. The process encompasses the steps of (a) mixing the polyene antibiotic and the phospholipid in an acidified organic solvent, (b) removing the organic solvent and (c) hydrating the dried complex with an aqueous buffer having a pH of 3 to 6.

Abstract translation: 本发明涉及一种制备多烯抗生素药物，优选两性霉素B的单层脂质体组合物的方法。该方法包括以下步骤：（a）在酸化的有机溶剂中混合多烯抗生素和磷脂，（b）除去 有机溶剂和（c）用pH为3至6的水性缓冲液使干燥的配合物水合。