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    PROCESS FOR THE PREPARATION OF UNILAMELLAR LIPOSOMAL COMPOSITION
    2.
    发明申请
    PROCESS FOR THE PREPARATION OF UNILAMELLAR LIPOSOMAL COMPOSITION 审中-公开
    制备纤维脂肪组织的方法

    公开(公告)号：WO2017056113A1

    公开(公告)日：2017-04-06

    申请号：PCT/IN2016/050330

    申请日：2016-09-30

    Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

    Inventor： NAIK, Sachin Pushkarray ,  SEJU, Ujjawal Jayantilal ,  BHOWMICK, Subhas Balaram

    IPC: A61K31/7048 ,  A61K9/127

    CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K31/7048

    Abstract: The present invention relates to a process for the preparation of unilamellar liposomal composition of a polyene antibiotic drug, preferably amphotericin B. The process encompasses the steps of (a) mixing the polyene antibiotic and the phospholipid in an acidified organic solvent, (b) removing the organic solvent and (c) hydrating the dried complex with an aqueous buffer having a pH of 3 to 6.

    Abstract translation: 本发明涉及一种制备多烯抗生素药物，优选两性霉素B的单层脂质体组合物的方法。该方法包括以下步骤：（a）在酸化的有机溶剂中混合多烯抗生素和磷脂，（b）除去 有机溶剂和（c）用pH为3至6的水性缓冲液使干燥的配合物水合。

    NANOPARTICULATE COMPOSITION
    3.
    发明申请
    NANOPARTICULATE COMPOSITION 审中-公开
    纳米颗粒组合物

    公开(公告)号：WO2016135754A1

    公开(公告)日：2016-09-01

    申请号：PCT/IN2016/050068

    申请日：2016-02-25

    Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD

    Inventor： BOMMAGANI, Madhusudhan ,  BHOWMICK, Subhas Balaram ,  KANE, Prashant ,  DUBEY, Vaibhav

    IPC: A61K9/00 ,  A61K9/06 ,  A61K9/12 ,  A61K9/51 ,  A61K31/65

    CPC classification number: A61K9/146 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/122 ,  A61K31/65 ,  A61K47/14 ,  Y02A50/473

    Abstract: The present invention relates to a nanoparticulate topical composition comprising (i) nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm, (ii) one or more wetting agent and (iii) a non-aqueous liquid vehicle, wherein the composition is free of water. The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.

    Abstract translation: 本发明涉及纳米颗粒局部组合物，其包含（i）水溶性和水易感活性成分或其药学上可接受的盐的纳米颗粒，其粒度分布使得90％的颗粒小于1000nm，（ii） 一种或多种润湿剂和（iii）非水液体载体，其中所述组合物不含水。 本发明还涉及通过局部施用包含水溶性和水敏感活性成分或其药学上可接受的盐的纳米颗粒的纳米颗粒局部组合物来治疗由细菌引起的痤疮，红斑痤疮，脓疱病或皮肤病的方法，其具有 使得90％的颗粒小于1000nm的粒度分布。

    STABLE PHARMACEUTICAL COMPOSITION
    6.
    发明申请
    STABLE PHARMACEUTICAL COMPOSITION 审中-公开
    稳定的药物组合物

    公开(公告)号：WO2012029076A2

    公开(公告)日：2012-03-08

    申请号：PCT/IN2011/000594

    申请日：2011-08-30

    Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD. ,  KHOPADE, Ajay Jaysingh ,  ARULSUDAR, N ,  BHOWMICK, Subhas Balaram ,  BOROLE, Bhushan Shrikant

    Inventor： KHOPADE, Ajay Jaysingh ,  ARULSUDAR, N ,  BHOWMICK, Subhas Balaram ,  BOROLE, Bhushan Shrikant

    IPC: A61K9/10

    CPC classification number: A61K9/0019 ,  A61K9/08 ,  A61K9/10

    Abstract: A pharmaceutical composition in the form of a solution comprising water insoluble therapeutically active ingredient and a close structural analog of the water insoluble active ingredient, one or more pharmaceutically acceptable excipients and one or more water miscible solvents wherein the water insoluble active ingredient is present in therapeutically effective amounts and the close structural analog is present in sufficient amounts such that when the composition is added to an aqueous vehicle it forms a nanodispersion suitable for intravenous infusion wherein said nanodispersion is stable for longer periods as compared to a dispersion formed from an identical composition but devoid of the close structural analog of the water insoluble active ingredient.

    Abstract translation: 包含水不溶性治疗活性成分和水不溶性活性成分的紧密结构类似物，一种或多种药学上可接受的赋形剂和一种或多种水混溶性溶剂的溶液形式的药物组合物，其中 水不溶性活性成分以治疗有效量存在，并且紧密结构类似物以足够的量存在，使得当组合物加入含水载体中时，其形成适于静脉内输注的纳米分散体，其中所述纳米分散体与 由相同组合物形成但不含水不溶性活性成分的密切结构类似物的分散体。

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